Search Results - "Heerspink, H."

Dapagliflozin a glucose-regulating drug with diuretic properties in subjects with type 2 diabetes by Lambers Heerspink, H. J., de Zeeuw, D., Wie, L., Leslie, B., List, J.

“…Aims Sodium–glucose co‐transporter 2 (SGLT2) reabsorbs glucose and sodium in the renal proximal tubule. Dapagliflozin, an SGLT2 inhibitor, targets…”
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A urinary peptide biomarker set predicts worsening of albuminuria in type 2 diabetes mellitus by Roscioni, S. S., de Zeeuw, D., Hellemons, M. E., Mischak, H., Zürbig, P., Bakker, S. J. L., Gansevoort, R. T., Reinhard, H., Persson, F., Lajer, M., Rossing, P., Heerspink, H. J. Lambers

“…Aims/hypothesis Microalbuminuria is considered the first clinical sign of kidney dysfunction and is associated with a poor renal and cardiovascular prognosis…”
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Dapagliflozin reduces albuminuria in patients with diabetes and hypertension receiving renin-angiotensin blockers by Heerspink, H. J. L., Johnsson, E., Gause-Nilsson, I., Cain, V. A., Sjöström, C. D.

“…Aims To characterize the effect of dapagliflozin on albuminuria and estimated glomerular filtration rate (eGFR) and to determine whether effects on albuminuria…”
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Urine and plasma metabolites predict the development of diabetic nephropathy in individuals with Type 2 diabetes mellitus by Pena, M. J., Lambers Heerspink, H. J., Hellemons, M. E., Friedrich, T., Dallmann, G., Lajer, M., Bakker, S. J. L., Gansevoort, R. T., Rossing, P., de Zeeuw, D., Roscioni, S. S.

“…Aims Early detection of individuals with Type 2 diabetes mellitus or hypertension at risk for micro‐ or macroalbuminuria may facilitate prevention and…”
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Effects of Direct Renin Blockade on Renal & Systemic Hemodynamics and on RAAS Activity, in Weight Excess and Hypertension: A Randomized Clinical Trial by Kwakernaak, A J, Roksnoer, L C, Lambers Heerspink, H J, van den Berg-Garrelds, I, Lochorn, G A, van Embden Andres, J H, Klijn, M A, Kobori, H, Danser, A H J, Laverman, G D, Navis, G J

“…The combination of weight excess and hypertension significantly contributes to cardiovascular risk and progressive kidney damage. An unfavorable renal…”
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[18F]FDG and [18F]NaF as PET markers of systemic atherosclerosis progression: A longitudinal descriptive imaging study in patients with type 2 diabetes mellitus by Reijrink, M., de Boer, S.A., te Velde-Keyzer, C.A., Sluiter, J.K.E., Pol, R.A., Heerspink, H.J.L., Greuter, M.J.W., Hillebrands, J.L., Mulder, D.J., Slart, R.H.J.A.

“…While [18F]-fluordeoxyglucose ([18F]FDG) uptake is associated with arterial inflammation, [18F]-sodium fluoride ([18F]NaF) is a marker for arterial…”
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Quantitative aortic Na[ 18 F]F positron emission tomography computed tomography as a tool to associate vascular calcification with major adverse cardiovascular events by Lieverse, T G F, van Praagh, G D, Mulder, D J, Lambers Heerspink, H J, Wolterink, J M, Slart, R H J A

“…Sodium[ F]fluoride (Na[ F]F) used in positron emission tomography (PET) binds to active calcification and correlates consistently with higher cardiovascular…”
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Is a reduction in albuminuria associated with renal and cardiovascular protection? A post hoc analysis of the ALTITUDE trial by Heerspink, H. J. L., Ninomiya, T., Persson, F., Brenner, B. M., Brunel, P., Chaturvedi, N., Desai, A. S., Haffner, S. M., Mcmurray, J. J. V., Solomon, S. D., Pfeffer, M. A., Parving, H.-H., de Zeeuw, D.

“…Aims To investigate whether the degree of albuminuria reduction observed in the ALTITUDE trial is associated with renal and cardiovascular protection, and…”
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Early renin-angiotensin system intervention is more beneficial than late intervention in delaying end-stage renal disease in patients with type 2 diabetes by Schievink, B., Kröpelin, T., Mulder, S., Parving, H.-H., Remuzzi, G., Dwyer, J., Vemer, P., de Zeeuw, D., Lambers Heerspink, H. J.

“…Aims To develop and validate a model to simulate progression of diabetic kidney disease (DKD) from early onset until end‐stage renal disease (ESRD), and to…”
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Increased serum potassium affects renal outcomes: a post hoc analysis of the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan (RENAAL) trial by Miao, Y, Dobre, D, Lambers Heerspink, H. J, Brenner, B. M, Cooper, M. E, Parving, H-H, Shahinfar, S, Grobbee, D, de Zeeuw, D

“…Aims/hypothesis To assess the effect of an angiotensin receptor blocker (ARB) on serum potassium and the effect of a serum potassium change on renal outcomes…”
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Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts by Astor, Brad C., Matsushita, Kunihiro, Gansevoort, Ron T., van der Velde, Marije, Woodward, Mark, Levey, Andrew S., Jong, Paul E. de, Coresh, Josef, the Chronic Kidney Disease Prognosis Consortium

“…We studied here the independent associations of estimated glomerular filtration rate (eGFR) and albuminuria with mortality and end-stage renal disease (ESRD)…”
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Predictors of response in initial users of metformin and sulphonylurea derivatives: a systematic review by Martono, D. P., Lub, R., Lambers Heerspink, H. J., Hak, E., Wilffert, B., Denig, P.

“…Aim To provide an overview of factors predicting metformin and sulphonylurea treatment response. Background A large variability between individuals in…”
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Validity of biomarkers predicting onset or progression of nephropathy in patients with Type 2 diabetes: a systematic review by Hellemons, M. E., Kerschbaum, J., Bakker, S. J. L., Neuwirt, H., Mayer, B., Mayer, G., de Zeeuw, D., Lambers Heerspink, H. J., Rudnicki, M.

“…Diabet. Med. 29, 567–577 (2012) Novel biomarkers predicting onset or progression of nephropathy in patients with Type 2 diabetes have been recently identified…”
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Comparison of urine collection methods for albuminuria assessment in young children by van den Belt, S.M., Gracchi, V., de Zeeuw, D., Heerspink, H.J.L.

“…Cotton wool or pantyliners placed in a diaper can be used as urine collection devices for albuminuria measurements in young, not continent children. We tested…”
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Predictors of mortality in hospital survivors with type 2 diabetes mellitus and acute coronary syndromes by Savonitto, Stefano, Morici, Nuccia, Nozza, Anna, Cosentino, Francesco, Perrone Filardi, Pasquale, Murena, Ernesto, Morocutti, Giorgio, Ferri, Marco, Cavallini, Claudio, Eijkemans, Marinus Jc, Stähli, Barbara E, Schrieks, Ilse C, Toyama, Tadashi, Lambers Heerspink, H J, Malmberg, Klas, Schwartz, Gregory G, Lincoff, A Michael, Ryden, Lars, Tardif, Jean Claude, Grobbee, Diederick E

“…To define the predictors of long-term mortality in patients with type 2 diabetes mellitus and recent acute coronary syndrome. A total of 7226 patients from a…”
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Individualized prediction of the effect of angiotensin receptor blockade on renal and cardiovascular outcomes in patients with diabetic nephropathy by van der Sande, N. G. C., Dorresteijn, J. A. N., Visseren, F. L. J., Dwyer, J. P., Blankestijn, P. J., van der Graaf, Y., Heerspink, H. L. J.

“…Aims To predict individualized treatment effects of angiotensin receptor blockers (ARBs) on cardiovascular and renal complications in order to help clinicians…”
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The Importance of Short-Term Off-Target Effects in Estimating the Long-Term Renal and Cardiovascular Protection of Angiotensin Receptor Blockers by Smink, P A, Miao, Y, Eijkemans, M J C, Bakker, S J L, Raz, I, Parving, H-H, Hoekman, J, Grobbee, D E, de Zeeuw, D, Lambers Heerspink, H J

“…Angiotensin receptor blockers (ARBs) have multiple effects that may contribute to their efficacy on renal/cardiovascular outcomes. We developed and validated a…”
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A dosing algorithm for metformin based on the relationships between exposure and renal clearance of metformin in patients with varying degrees of kidney function by Duong, Janna K., Kroonen, M. Y. A. M., Kumar, S. S., Heerspink, H. L., Kirkpatrick, C. M., Graham, G. G., Williams, K. M., Day, R. O.

“…Purpose The aims of this study were to investigate the relationship between metformin exposure, renal clearance (CL R ), and apparent non-renal clearance of…”
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A prediction of the renal and cardiovascular efficacy of aliskiren in ALTITUDE using short-term changes in multiple risk markers by Smink, PA, Hoekman, J, Grobbee, DE, Eijkemans, MJC, Parving, H-H, Persson, F, Ibsen, H, Lindholm, L, Wachtell, K, de Zeeuw, D, Heerspink, HJ Lambers

“…Introduction We recently developed and validated in existing trials a novel algorithm (PRE score) to predict long-term drug efficacy based on short-term…”
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Effect of Dapagliflozin on Cardiovascular Outcomes According to Baseline Kidney Function and Albuminuria Status in Patients With Type 2 Diabetes: A Prespecified Secondary Analysis of a Randomized Clinical Trial by Zelniker, Thomas A, Raz, Itamar, Mosenzon, Ofri, Dwyer, Jamie P, Heerspink, Hiddo H J L, Cahn, Avivit, Goodrich, Erica L, Im, Kyungah, Bhatt, Deepak L, Leiter, Lawrence A, McGuire, Darren K, Wilding, John P H, Gause-Nilsson, Ingrid, Langkilde, Anna Maria, Sabatine, Marc S, Wiviott, Stephen D

“…Sodium-glucose cotransporter 2 inhibitors, such as dapagliflozin, promote renal glucose excretion and reduce cardiovascular (CV) deaths and hospitalizations…”
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