Search Results - "Heerema, N. A."

Long-term follow-up of imatinib in pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia: Children's Oncology Group Study AALL0031 by Schultz, K R, Carroll, A, Heerema, N A, Bowman, W P, Aledo, A, Slayton, W B, Sather, H, Devidas, M, Zheng, H W, Davies, S M, Gaynon, P S, Trigg, M, Rutledge, R, Jorstad, D, Winick, N, Borowitz, M J, Hunger, S P, Carroll, W L, Camitta, B

“…We previously reported preliminary findings that post induction imatinib mesylate (340 mg/m 2 /day), in combination with intensive chemotherapy, resulted in…”
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Enhanced Risk Stratification for Children and Young Adults with B-Cell Acute Lymphoblastic Leukemia: A Children’s Oncology Group Report by DelRocco, N. J., Loh, M. L., Borowitz, M. J., Gupta, S., Rabin, K. R., Zweidler-McKay, P., Maloney, K. W., Mattano, L. A., Larsen, E., Angiolillo, A., Schore, R. J., Burke, M. J., Salzer, W. L., Wood, B. L., Carroll, A. J., Heerema, N. A., Reshmi, S. C., Gastier-Foster, J. M., Harvey, R., Chen, I. M., Roberts, K. G., Mullighan, C. G., Willman, C., Winick, N., Carroll, W. L., Rau, R. E., Teachey, D. T., Hunger, S. P., Raetz, E. A., Devidas, M., Kairalla, J. A.

“…Current strategies to treat pediatric acute lymphoblastic leukemia rely on risk stratification algorithms using categorical data. We investigated whether using…”
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Wwox–Brca1 interaction: role in DNA repair pathway choice by Schrock, M S, Batar, B, Lee, J, Druck, T, Ferguson, B, Cho, J H, Akakpo, K, Hagrass, H, Heerema, N A, Xia, F, Parvin, J D, Aldaz, C M, Huebner, K

“…In this study, loss of expression of the fragile site-encoded Wwox protein was found to contribute to radiation and cisplatin resistance of cells, responses…”
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Specific cytogenetic abnormalities are associated with a significantly inferior outcome in children and adolescents with mature B-cell non-Hodgkin's lymphoma: results of the FAB LMB 96 international study by Poirel, H A, Cairo, M S, Heerema, N A, Swansbury, J, Aupérin, A, Launay, E, Sanger, W G, Talley, P, Perkins, S L, Raphaël, M, McCarthy, K, Sposto, R, Gerrard, M, Bernheim, A, Patte, C

“…Clinical studies showed that advanced stage, high LDH, poor response to reduction therapy and combined bone marrow and central nervous system disease are…”
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Children's Cancer Group trials in childhood acute lymphoblastic leukemia : 1983-1995 by GAYNON, P. S, TRIGG, M. E, HEEREMA, N. A, SENSEL, M. G, SATHER, H. N, HAMMOND, G. D, BLEYER, W. A

“…Since 1968, the Children's Cancer Group (CCG) has treated more than 16,000 children with acute lymphoblastic leukemia (ALL). Herein, we report improvements…”
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High concordance from independent studies by the Children's Cancer Group (CCG) and Pediatric Oncology Group (POG) associating favorable prognosis with combined trisomies 4, 10, and 17 in children with NCI Standard-Risk B-precursor Acute Lymphoblastic Leukemia: a Children's Oncology Group (COG) initiative by SUTCLIFFE, M. J, SHUSTER, J. J, SATHER, H. N, CAMITTA, B. M, PULLEN, J, SCHULTZ, K. R, BOROWITZ, M. J, GAYNON, P. S, CARROLL, A. J, HEEREMA, N. A

“…Chromosome aberrations have a major role in pediatric acute lymphoblastic leukemia (ALL) risk assignment. The Children's Cancer Group (CCG) and the Pediatric…”
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Multiplex PCR: critical parameters and step-by-step protocol by Henegariu, O, Heerema, N A, Dlouhy, S R, Vance, G H, Vogt, P H

“…By simultaneously amplifying more than one locus in the same reaction, multiplex PCR is becoming a rapid and convenient screening assay in both the clinical…”
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Prevalence and clinical implications of NRAS mutations in childhood AML: a report from the Children's Oncology Group by Berman, J N, Gerbing, R B, Alonzo, T A, Ho, P A, Miller, K, Hurwitz, C, Heerema, N A, Hirsch, B, Raimondi, S C, Lange, B, Franklin, J L, Gamis, A, Meshinchi, S

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A retrospective study of 69 patients with t(6;9)(p23;q34) AML emphasizes the need for a prospective, multicenter initiative for rare 'poor prognosis' myeloid malignancies by SLOVAK, M. L, GUNDACKER, H, WILLMAN, C. L, RAVINDRANATH, Y, ALONZO, T. A, CARROLL, A. J, RAIMONDI, S. C, HEEREMA, N. A, BLOOMFIELD, C. D, DEWALD, G, APPELBAUM, F. R, LARSON, R. A, TALLMAN, M. S, BENNETT, J. M, STIREWALT, D. L, MESHINCHI, S

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Genomic profiling in Down syndrome acute lymphoblastic leukemia identifies histone gene deletions associated with altered methylation profiles by Loudin, M G, Wang, J, Eastwood Leung, H-C, Gurusiddappa, S, Meyer, J, Condos, G, Morrison, D, Tsimelzon, A, Devidas, M, Heerema, N A, Carroll, A J, Plon, S E, Hunger, S P, Basso, G, Pession, A, Bhojwani, D, Carroll, W L, Rabin, K R

“…Patients with Down syndrome (DS) and acute lymphoblastic leukemia (ALL) have distinct clinical and biological features. Whereas most DS-ALL cases lack the…”
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Cytogenetics and outcome of infants with acute lymphoblastic leukemia and absence of MLL rearrangements by De Lorenzo, P, Moorman, A V, Pieters, R, Dreyer, Z E, Heerema, N A, Carroll, A J, Hunger, S P, Harvey, R, Willman, C L, Devidas, M, Valsecchi, M-G, Harrison, C J

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Deletion of 7p or monosomy 7 in pediatric acute lymphoblastic leukemia is an adverse prognostic factor: a report from the Children's Cancer Group by HEEREMA, N. A, NACHMAN, J. B, SATHER, H. N, LA, M. K, HUTCHINSON, R, LANGE, B. J, BOSTROM, B, STEINHERZ, P. G, GAYNON, P. S, UCKUN, F. M

“…Monosomy 7 or deletions of 7q are associated with many myeloid disorders; however, the significance of such abnormalities in childhood acute lymphoblastic…”
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Maternal vitamin and iron supplementation and risk of infant leukaemia: a report from the Children's Oncology Group by Linabery, A M, Puumala, S E, Hilden, J M, Davies, S M, Heerema, N A, Roesler, M A, Ross, J A

“…Background: Prenatal supplementation has been inversely associated with childhood, but not with infant, leukaemia. Methods: Mothers of 443 cases of infant…”
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Expression of HOX11 in childhood T-lineage acute lymphoblastic leukaemia can occur in the absence of cytogenetic aberration at 10q24: a study from the Children's Cancer Group (CCG) by KEES, U. R, HEEREMA, N. A, KUMAR, R, WATT, P. M, BAKER, D. L, LA, M. K, UCKUN, F. M, SATHER, H. N

“…Clonal genetic aberrations in tumour cells provide critical information for the development of new diagnostic and therapeutic strategies for patients. In…”
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Secondary cytogenetic aberrations in childhood Philadelphia chromosome positive acute lymphoblastic leukemia are nonrandom and may be associated with outcome by HEEREMA, N. A, HARBOTT, J, AUCLERC, M-F, CARROLL, A. J, CONTER, V, HARRISON, C. J, PULLEN, J, RAIMONDI, S. C, RICHARDS, S, RIEHM, H, SATHER, H. N, SHUSTER, J. J, GALIMBERTI, S, SILVERMAN, L. B, VALSECCHI, M. G, ARICO, M, CAMITTA, B. M, GAYNON, P. S, JANKA-SCHAUB, G, KAMPS, W, BASSO, G, PUI, C-H, SCHRAPPE, M

“…Additional chromosomal aberrations occur frequently in Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia (ALL) of childhood. The treatment…”
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Cytogenetic studies of infant acute lymphoblastic leukemia : Poor prognosis of infants with t(4;11) : A report of the Children's Cancer Group by HEEREMA, N. A, SATHER, H. N, GE, J, ARTHUR, D. C, HILDEN, J. M, TRIGG, M. E, REAMAN, G. H

“…Infants less than 1 year of age at diagnosis of acute lymphoblastic leukemia (ALL) have a poor prognosis, which has been attributed primarily to a breakpoint…”
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Hypodiploidy With Less Than 45 Chromosomes Confers Adverse Risk in Childhood Acute Lymphoblastic Leukemia: A Report From the Children's Cancer Group by Heerema, Nyla A., Nachman, James B., Sather, Harland N., Sensel, Martha G., Lee, Mei K., Hutchinson, Raymond, Lange, Beverly J., Steinherz, Peter G., Bostrom, Bruce, Gaynon, Paul S., Uckun, Fatih

“…We have determined the prognostic significance of hypodiploidy (<46 chromosomes) in a large cohort of children with acute lymphoblastic leukemia (ALL) treated…”
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Filgrastim and alemtuzumab (Campath-1H) for refractory chronic lymphocytic leukemia by LIN, T. S, FLINN, I. W, LUCAS, M. S, PORCU, P, SICKLER, J, MORAN, M. E, LUCAS, D. M, HEEREMA, N. A, GREVER, M. R, BYRD, J. C

“…Alemtuzumab (anti-CD52; Campath-1H) is effective in fludarabine-refractory chronic lymphocytic leukemia (CLL), but is associated with infection and early onset…”
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Childhood and maternal infections and risk of acute leukaemia in children with Down syndrome: a report from the Children's Oncology Group by CANFIELD, K. N, SPECTOR, L. G, ROSS, J. A, ROBISON, L. L, LAZOVICH, D, ROESLER, M, OLSHAN, A. F, SMITHS, F. O, HEEREMA, N. A, BARNARD, D. R, BLAIR, C. K

“…Children with Down syndrome (DS) are highly susceptible to acute leukaemia. Given the potential role of infections in the aetiology of leukaemia in children…”
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Cytogenetic features of infants less than 12 months of age at diagnosis of acute lymphoblastic leukemia : impact of the 11q23 breakpoint on outcome : a report of the Childrens Cancer Group by HEEREMA, N. A, ARTHUR, D. C, SATHER, H, ALBO, V, FEUSNER, J, LANGE, B. J, STEINHERZ, P. G, ZELTZER, P, HAMMOND, D, REAMAN, G. H

“…Cytogenetic analyses of pretreatment bone marrows were performed at local institutions as part of Childrens Cancer Group (CCG) protocol CCG-107 for infants…”
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