Search Results - "Heerebeek, Loek"

Connecting heart failure with preserved ejection fraction and renal dysfunction: the role of endothelial dysfunction and inflammation by ter Maaten, Jozine M., Damman, Kevin, Verhaar, Marianne C., Paulus, Walter J., Duncker, Dirk J., Cheng, Caroline, van Heerebeek, Loek, Hillege, Hans L., Lam, Carolyn S.P., Navis, Gerjan, Voors, Adriaan A.

“…Renal dysfunction in heart failure with preserved ejection fraction (HFpEF) is common and is associated with increased mortality. Impaired renal function is…”
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Serial cardiac biomarkers, pulmonary artery pressures and traditional parameters of fluid status in relation to prognosis in patients with chronic heart failure: Design and rationale of the BioMEMS study by Allach, Youssra, Barry‐Loncq de Jong, Mylene, Clephas, Pascal R.D., Gent, Marco W.F., Brunner‐La Rocca, Hans‐Peter, Szymanski, Mariusz K., Halm, Vokko P., Handoko, M. Louis, Kok, Wouter E.M., Asselbergs, Folkert W., Kimmenade, Roland R.J., Manintveld, Olivier C., Mieghem, Nicolas M.D.A., Beeres, Saskia L.M.A., Rienstra, Michiel, Post, Marco C., Heerebeek, Loek, Borleffs, C. Jan Willem, Tukkie, Raymond, Mosterd, Arend, Linssen, Gerard C.M., Spee, Ruud F., Emans, Mireille E., Smilde, Tom D.J., Ramshorst, Jan, Kirchhof, Charles J.H.J., Feenema‐Aardema, Margriet W., Fonseca, Carlos A., Heuvel, Mieke, Hazeleger, Ronald, Eck, J.W. Martijn, Boersma, Eric, Kardys, Isabella, Boer, Rudolf A., Brugts, Jasper J.

“…Aims Heart failure (HF), a global pandemic affecting millions of individuals, calls for adequate predictive guidance for improved therapy. Congestion, a key…”
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Outpatient treatment of worsening heart failure with intravenous and subcutaneous diuretics: a systematic review of the literature by Wierda, Eric, Dickhoff, Cathelijne, Handoko, Martin Louis, Oosterom, Liane, Kok, Wouter Emmanuel, Rover, Y., Mol, B.A.J.M., Heerebeek, Loek, Schroeder‐Tanka, Jutta Maria

“…Aims In the coming decade, heart failure (HF) represents a major global healthcare challenge due to an ageing population and rising prevalence combined with…”
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Stratified Treatment of Heart Failure with preserved Ejection Fraction: rationale and design of the STADIA‐HFpEF trial by Scheffer, Mariëlle, Driessen‐Waaijer, Annet, Hamdani, Nazha, Landzaat, Jochem W.D., Jonkman, Nini H., Paulus, Walter J., Heerebeek, Loek

“…Aims High myocardial stiffness in heart failure with preserved ejection fraction (HFpEF) is attributed to comorbidity‐induced structural and functional…”
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Ancient Gunpowder and Novel Insights Team Up Against Heart Failure With Preserved Ejection Fraction by Paulus, Walter J., MD, PhD, van Heerebeek, Loek, MD, PhD

“…First among the proposed mechanisms for exercise intolerance in HFpEF is high LV diastolic stiffness (5), which elicits a prompt and large increase in PCWP…”
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The quest for determination of standard reference values of right ventricular longitudinal systolic strain: a systematic review and meta-analysis by Landzaat, Jochem W. D., van Heerebeek, Loek, Jonkman, Nini H., van der Bijl, Esther M., Riezebos, Robert K.

“…Right ventricular function is strongly associated with clinical outcomes in many conditions, and the evaluation of right ventricle (RV) structure and function…”
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Guideline implementation, drug sequencing, and quality of care in heart failure: design and rationale of TITRATE‐HF by Clephas, Pascal R. D., Malgie, Jishnu, Schaap, Jeroen, Koudstaal, Stefan, Emans, Mireille, Linssen, Gerard C. M., Boer, Grytsje A., Heerebeek, Loek, Borleffs, C. Jan Willem, Manintveld, Olivier C., Empel, Vanessa, Wijk, Sandra, Heuvel, Mieke, Fonseca, Carlos, Damman, Kevin, Ramshorst, Jan, Kimmenade, Roland, Ven, Arjen R. T., Tio, René A., Veghel, Dennis, Asselbergs, Folkert W., Boer, Rudolf A., Meer, Peter, Greene, Stephen J., Brunner‐La Rocca, Hans‐Peter, Brugts, Jasper J.

“…Aims Current heart failure (HF) guidelines recommend to prescribe four drug classes in patients with HF with reduced ejection fraction (HFrEF). A clear…”
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Diabetes Mellitus Worsens Diastolic Left Ventricular Dysfunction in Aortic Stenosis Through Altered Myocardial Structure and Cardiomyocyte Stiffness by FALCAO-PIRES, Ines, HAMDANI, Nazha, PAULUS, Walter J, BORBELY, Attila, GAVINA, Cristina, SCHALKWIJK, Casper G, VAN DER VELDEN, Jolanda, VAN HEEREBEEK, Loek, STIENEN, Ger J. M, NIESSEN, Hans W. M, LEITE-MOREIRA, Adelino F

“…Aortic stenosis (AS) and diabetes mellitus (DM) are frequent comorbidities in aging populations. In heart failure, DM worsens diastolic left ventricular (LV)…”
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Hypophosphorylation of the Stiff N2B Titin Isoform Raises Cardiomyocyte Resting Tension in Failing Human Myocardium by Borbély, Attila, Falcao-Pires, Ines, van Heerebeek, Loek, Hamdani, Nazha, Édes, István, Gavina, Cristina, Leite-Moreira, Adelino F, Bronzwaer, Jean G.F, Papp, Zoltán, van der Velden, Jolanda, Stienen, Ger J.M, Paulus, Walter J

“…High diastolic stiffness of failing myocardium results from interstitial fibrosis and elevated resting tension (Fpassive) of cardiomyocytes. A shift in titin…”
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Paclitaxel-Eluting versus Uncoated Stents in Primary Percutaneous Coronary Intervention by Laarman, Gerrit J, Suttorp, Maarten J, Dirksen, Maurits T, van Heerebeek, Loek, Kiemeneij, Ferdinand, Slagboom, Ton, van der Wieken, L. Ron, Tijssen, Jan G.P, Rensing, Benno J, Patterson, Mark

“…The Paclitaxel-Eluting Stent versus Conventional Stent in Myocardial Infarction with ST-Segment Elevation (PASSION) trial compared the use of…”
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Myocardial structure and function differ in systolic and diastolic heart failure by VAN HEEREBEEK, Loek, BORBELY, Attila, NIESSEN, Hans W. M, BRONZWAER, Jean G. F, VAN DER VELDEN, Jolanda, STIENEN, Ger J. M, LINKE, Wolfgang A, LAARMAN, Gerrit J, PAULUS, Walter J

“…To support the clinical distinction between systolic heart failure (SHF) and diastolic heart failure (DHF), left ventricular (LV) myocardial structure and…”
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Familial catamenial coronary spasms by de Groot, Elisabeth A A, van Heerebeek, Loek, Vink, Maarten A, Kuipers, Remko S

“…Coronary artery spasms represent important causes of myocardial ischaemia and infarction in patients with non-obstructive coronary artery disease. They are…”
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The failing diabetic heart: Focus on diastolic left ventricular dysfunction by van Heerebeek, Loek, Somsen, Aernout, Paulus, Walter J.

“…Diabetes mellitus (DM) is highly prevalent and is an important risk factor for congestive heart failure (HF). Increased left ventricular (LV) diastolic…”
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Natriuretic Peptide Levels and Stages of Left Ventricular Dysfunction in Heart Failure with Preserved Ejection Fraction by Dal Canto, Elisa, Scheffer, Marielle, Kortekaas, Kirsten, Driessen-Waaijer, Annet, Paulus, Walter J, van Heerebeek, Loek

“…In heart failure with preserved ejection fraction (HFpEF), natriuretic peptide (NP) levels are frequently lower. In several trials, the outcome differed…”
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The dialogue between diabetes and diastole by van Heerebeek, Loek, Paulus, Walter J.

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The Effect of the Timing of Invasive Management on Cardiac Function in Patients with NSTE-ACS, Insights from the OPTIMA-2 Randomized Controlled Trial by Fagel, Nick D., Leuven, Stefan G. J., Kikkert, Wouter J., de Leau, Michelle M., van Heerebeek, Loek, Riezebos, Robert K.

“…The timing of coronary angiography in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) remains a matter of debate. The relationship between…”
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Distinct myocardial effects of beta-blocker therapy in heart failure with normal and reduced left ventricular ejection fraction by Hamdani, Nazha, Paulus, Walter J., van Heerebeek, Loek, Borbély, Attila, Boontje, Nicky M., Zuidwijk, Marian J., Bronzwaer, Jean G.F., Simonides, Warner S., Niessen, Hans W. M., Stienen, Ger J. M., van der Velden, Jolanda

“…Aims Left ventricular (LV) myocardial structure and function differ in heart failure (HF) with normal (N) and reduced (R) LV ejection fraction (EF). This…”
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Circulating white blood cells and platelets amplify oxidative stress in heart failure by Paulus, Walter J, IJsselmuiden, Alexander JJ, Musters, René JP, de Ruiter, Gijsbert, van Heerebeek, Loek, Alderse-Baas, Frans, van Schilfgaarde, Muriel, Leyte, Anja, Tangelder, Geert-Jan, Laarman, Gerrit J

“…Mitochondria of circulating white blood cells (WBC) and platelets sense oxidative stress during capillary passage and react by producing reactive oxygen…”
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Phenotype-Specific Treatment of Heart Failure With Preserved Ejection Fraction: A Multiorgan Roadmap by Shah, Sanjiv J, Kitzman, Dalane W, Borlaug, Barry A, van Heerebeek, Loek, Zile, Michael R, Kass, David A, Paulus, Walter J

“…Heart failure (HF) with preserved ejection fraction (EF; HFpEF) accounts for 50% of HF cases, and its prevalence relative to HF with reduced EF continues to…”
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Empagliflozin improves endothelial and cardiomyocyte function in human heart failure with preserved ejection fraction via reduced pro-inflammatory-oxidative pathways and protein kinase Gα oxidation by Kolijn, Detmar, Pabel, Steffen, Tian, Yanna, Lódi, Mária, Herwig, Melissa, Carrizzo, Albino, Zhazykbayeva, Saltanat, Kovács, Árpád, Fülöp, Gábor Á, Falcão-Pires, Inês, Reusch, Peter H, Linthout, Sophie Van, Papp, Zoltán, van Heerebeek, Loek, Vecchione, Carmine, Maier, Lars S, Ciccarelli, Michele, Tschöpe, Carsten, Mügge, Andreas, Bagi, Zsolt, Sossalla, Samuel, Hamdani, Nazha

“…Abstract Aims Sodium-glucose-cotransporter-2 inhibitors showed favourable cardiovascular outcomes, but the underlying mechanisms are still elusive. This study…”
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