Search Results - "Heerde, W. L."

Clinically relevant differences between assays for von Willebrand factor activity by Boender, J., Eikenboom, J., Bom, J. G., Meijer, K., Meris, J., Fijnvandraat, K., Cnossen, M. H., Laros‐van Gorkom, B. A. P., Heerde, W. L., Mauser‐Bunschoten, E. P., Maat, M. P. M., Leebeek, F. W. G.

“…Essentials It is unclear whether there are differences between von Willebrand factor (VWF) activity assays. We compared the four most used VWF activity assays…”
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Mechanisms and clinical implications of thrombosis in paroxysmal nocturnal hemoglobinuria by VAN BIJNEN, S. T. A., VAN HEERDE, W. L., MUUS, P.

“…Paroxysmal nocturnal hemoglobinuria (PNH) is a rare acquired disease characterized by a clone of blood cells lacking glycosyl phosphatidylinositol…”
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Clinical phenotype in genetically confirmed von Willebrand disease type 2N patients reflects a haemophilia A phenotype by van Meegeren, M. E. R., Mancini, T. L., Schoormans, S. C. M., van Haren, B. J. T., van Duren, C., Diekstra, A., Laros-van Gorkom, B. A. P., Brons, P. P. T., Simons, A., Hoefsloot, L., van Heerde, W. L.

“…Introduction: Von Willebrand disease (VWD) type 2N is characterized by a defective binding of factor VIII (FVIII) to von Willebrand factor (VWF) resulting in…”
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Annexin A5 polymorphism (−1C→T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome by de Laat, B, Derksen, R H W M, Mackie, I J, Roest, M, Schoormans, S, Woodhams, B J, de Groot, P G, van Heerde, W L

“…Background: Annexin A5 is thought to have a role in the pathophysiology of the antiphospholipid syndrome (APS)—a syndrome characterised by recurrent thrombosis…”
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Visualisation of cell death in vivo in patients with acute myocardial infarction by Hofstra, Leo, Liem, Ing Han, Dumont, Ewald A, Boersma, Hendricus H, van Heerde, Waander L, Doevendans, Pieter A, DeMuinck, Ebo, Wellens, HJJ, Kemerink, Gerrit J, Reutelingsperger, Chris PM, Heidendal, Guido A

“…In-vivo visualisation and quantification of the extent and time-frame of cell death after acute myocardial infarction would be of great interest. We studied…”
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Transient expression of phosphatidylserine at cell-cell contact areas is required for myotube formation by van den Eijnde, S M, van den Hoff, M J, Reutelingsperger, C P, van Heerde, W L, Henfling, M E, Vermeij-Keers, C, Schutte, B, Borgers, M, Ramaekers, F C

“…Cell surface exposure of phosphatidylserine (PS) is shown to be part of normal physiology of skeletal muscle development and to mediate myotube formation. A…”
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Hemorrhagic disorders of fibrinolysis: a clinical review by Saes, J. L., Schols, S. E. M., van Heerde, W. L., Nijziel, M. R.

“…Summary Hyperfibrinolytic bleeding can be caused by a deficiency of one of the inhibitors of fibrinolysis (plasminogen activator inhibitor type 1 [PAI‐1] or…”
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Annexin V, the regulator of phosphatidylserine-catalyzed inflammation and coagulation during apoptosis by Reutelingsperger, C P, van Heerde, W L

“…Annexin V belongs to a family of phospholipid binding proteins, the Annexins. It binds in the presence of Ca(2+)-ions with high affinity to negatively charged…”
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Matrix Metalloproteinase-9 Gene −1562C/T Polymorphism Mitigates Preeclampsia by Coolman, M, de Maat, M, Van Heerde, W.L, Felida, L, Schoormans, S, Steegers, E.A.P, Bertina, R.M, de Groot, C.J.M

“…Abstract Although the aetiology of preeclampsia is unknown, there is substantial evidence that it finds its roots in abnormal placentation. Prerequisites for…”
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Antithrombotic action of annexin V proved as efficient as direct inhibition of tissue factor or thrombin by Galán, A. M., Van Heerde, W. L., Escolar, G., Ordinas, A., Sixma, J., De Groot, P. G.

“…Background  The role of phospholipid platelet membrane and tissue factor in thrombin generation and thrombus formation is accepted. In the present study we…”
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In Vivo Detection of Apoptosis in an Intracardiac Tumor by Hofstra, L, Dumont, E. A, Thimister, P. W. L, Heidendal, G. A. K, DeBruine, A. P, Elenbaas, T. W. O, Boersma, H. H, van Heerde, W. L, Reutelingsperger, C. P. M

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The complexity of the phospholipid binding protein Annexin V by van Heerde, W L, de Groot, P G, Reutelingsperger, C P

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Major differences in clinical presentation, diagnosis and management of men and women with autosomal inherited bleeding disorders by Atiq, F., Saes, J.L., Punt, M.C., van Galen, K.P.M., Schutgens, R.E.G., Meijer, K., Cnossen, M.H., Laros-Van Gorkom, B.A.P., Peters, M., Nieuwenhuizen, L., Kruip, M.J.H.A., de Meris, J., van der Bom, J.G., van der Meer, F.J.M., Fijnvandraat, K., Kruis, I.C., van Heerde, W.L., Eikenboom, H.C.J., Leebeek, Frank W.G., Schols, S.E.M.

“…In recent years, more awareness is raised about sex-specific dilemmas in inherited bleeding disorders. However, no large studies have been performed to assess…”
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Low‐titre inhibitors, undetectable by the Nijmegen assay, reduce factor VIII half‐life after immune tolerance induction by DARDIKH, M., ALBERT, T., MASEREEUW, R., OLDENBURG, J., NOVAKOVA, I., VAN HEERDE, W. L., VERBRUGGEN, B.

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Alterations in markers of coagulation and fibrinolysis in patients with Paroxysmal Nocturnal Hemoglobinuria before and during treatment with eculizumab by van Bijnen, S.T.A, Østerud, B, Barteling, W, Verbeek-Knobbe, K, Willemsen, M, van Heerde, W.L, Muus, P

“…Abstract Background Paroxysmal Nocturnal Hemoglobinuria is characterized by complement-mediated hemolysis and an increased thrombosis risk. Eculizumab, an…”
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Retrospective evaluation of bleeding tendency and simultaneous thrombin and plasmin generation in patients with rare bleeding disorders by Van GEFFEN, M., MENEGATTI, M., LOOF, A., LAP, P., KARIMI, M., LAROS-van GORKOM, B. A. P., BRONS, P., Van HEERDE, W. L.

“…Rare bleeding disorders (RBDs) are a heterogeneous group of diseases with varying bleeding tendency, only partially explained by their laboratory phenotype. We…”
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Plasma annexin A5 and microparticle phosphatidylserine levels are elevated in sickle cell disease and increase further during painful crisis by van Tits, L.J., van Heerde, W.L., Landburg, P.P., Boderie, M.J., Muskiet, F.A.J., Jacobs, N., Duits, A.J., Schnog, J.B.

“…Expression of phosphatidylserine (PS) on the membrane surface of red blood cells and circulating microparticles (MP) plays an important role in etiology of the…”
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In situ detection of apoptosis in dental and periodontal tissues of the adult mouse using annexin-V-biotin by Bronckers, A L, Goei, S W, Dumont, E, Lyaruu, D M, Wöltgens, J H, van Heerde, W L, Reutelingsperger, C P, van den Eijnde, S M

“…An early event in apoptosis is exposure of phosphatidylserine, an aminophospholipid normally present in the inner leaflet of the plasma membranes, at the outer…”
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The C‐1T mutation in the annexin A5 Kozak sequence slightly increases the risk of myocardial infarction in men by Kenis, H., Doggen, C. J. M., Vos, H. L., Reutelingsperger, C. P. M., Van Heerde, W. L.

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The Annexin A5–1C/T polymorphism in ischemic stroke: a case–control study by VAN GOOR, M.‐L. P. J., VAN HEERDE, W. L., SCHOORMANS, S., DIPPEL, D. W. J., LEEBEEK, F. W. G.

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