Search Results - "Heene, Dieter L"

The fibrin assay comparison trial (FACT): correlation of soluble fibrin assays with D-dimer by Dempfle, C E, Zips, S, Ergül, H, Heene, D L

“…Soluble fibrin (SF) is regarded as an indicator of acute fibrin formation and a precursor of fibrin thrombi. Using a set of clinical plasma samples, and fibrin…”
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Anti-r-hirudin antibodies reveal clinical relevance through direct functional inactivation of r-hirudin or prolongation of r-hirudin's plasma halflife by Huhle, G, Liebe, V, Hudek, R, Heene, D L

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Pharmacokinetics of methotrexate-albumin conjugates in tumor-bearing rats by Stehle, G, Wunder, A, Sinn, H, Schrenk, H H, Schütt, S, Frei, E, Hartung, G, Maier-Borst, W, Heene, D L

“…Linking chemotherapeutic drugs to a macromolecular carrier system may enhance tumor targeting, reduce toxicity and overcome drug resistance mechanisms. As an…”
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Chromatographic and electrophoretic applications for the analysis of heparin and dermatan sulfate by Malsch, Reinhard, Harenberg, Job, Piazolo, Lukas, Huhle, Günther, Heene, Dieter L.

“…Heparin and dermatan sulfate are highly sulfated polydisperse glycosaminoglycans. The methods to determine such compounds include chromatographic and…”
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Analysis of fibrin formation and proteolysis during intravenous administration of ancrod by Dempfle, Carl-Erik, Argiriou, Sotiria, Kucher, Klaus, Müller-Peltzer, H., Rübsamen, Klaus, Heene, Dieter L.

“…Ancrod is a purified fraction of venom from the Malayan pit viper, Calloselasma rhodostoma, currently under investigation for treatment of acute ischemic…”
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Albumin-based drug carriers: comparison between serum albumins of different species on pharmacokinetics and tumor uptake of the conjugate by Stehle, G, Wunder, A, Schrenk, H H, Hartung, G, Heene, D L, Sinn, H

“…Albumin-based drug carrier systems have been developed in the field of chemotherapy to improve the passive tumor targeting properties of anti-cancer drugs…”
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A New Therapeutic Option by Subcutaneous Recombinant Hirudin in Patients with Heparin-induced Thrombocytopenia Type II: A Pilot Study by Huhle, Günter, Hoffmann, Ursula, Hoffmann, Ines, Liebe, Volker, Harenberg, Job F, Heene, Dieter L

“…We prospectively studied 15 patients suffering from acute heparin-induced thrombocytopenia (HIT) type II with n=10 and without n=5 thromboembolic events and 4…”
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High-resolution capillary electrophoresis and polycrylamide gel electrophoresis of heparins by Malsch, Reinhard, Harenberg, Job, Heene, Dieter L.

“…Heparin-oligosaccharides, low-molecular-mass heparins (LMMHs) and heparins were determined using high-resolution capillary electrophoresis (HPCE) and…”
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Methotrexate-albumin conjugate causes tumor growth delay in Dunning R3327 HI prostate cancer-bearing rats by Stehle, G, Wunder, A, Schrenk, H H, Hartung, G, Heene, D L, Sinn, H

“…Based on the rationale of a preferred albumin uptake by tumors, conjugates comprising of rat serum albumin (RSA) as a drug carrier and of methotrexate (MTX) as…”
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Is Albumin Administration Harmful in Critically Ill Patients? The Patient's Nitrogen and Energy Balance May Provide an Answer by Stehle, Gerd, Wunder, Andreas, Heene, Dieter L

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Fibrinogen heterogeneity in homozygous plasminogen deficiency type I: further evidence that plasmin is not involved in formation of LMW- and LMW'-fibrinogen by Dempfle, C E, Pfitzner, S A, Schott, D, Niessen, K H, Heene, D L

“…Human plasma fibrinogen is heterogeneous in SDS-polyacrylamide gel electrophoresis and other methods for separation of proteins by molecular size. A high…”
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Analysis of fibrin formation and proteolysis during intravenous administration of ancrod by Dempfle, Carl-Erik, Argiriou, Sotiria, Kucher, Klaus, Müller-Peltzer, H., Rübsamen, Klaus, Heene, Dieter L.

“…Ancrod is a purified fraction of venom from the Malayan pit viper, Calloselasma rhodostoma, currently under investigation for treatment of acute ischemic…”
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Long-term anticoagulation of outpatients with adverse events to oral anticoagulants using low-molecular-weight heparin by Harenberg, J, Huhle, G, Piazolo, L, Giese, C, Heene, D L

“…Bleeding complications are one of the major risks during oral anticoagulation. If further anticoagulation is indicated, low-molecular-weight heparin (LMWH) may…”
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The effect of self-monitoring the INR on quality of anticoagulation and quality of life by Kulinna, W, Ney, D, Wenzel, T, Heene, D L, Harenberg, J

“…In a prospective cohort study the influence of self-monitoring of the International Normalized Ratio (INR) was examined on 100 consecutive patients for a…”
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Fibrin formation and proteolysis during ancrod treatment. Evidence for des-A-profibrin formation and thrombin independent factor XIII activity by Dempfle, C E, Argiriou, S, Alesci, S, Kucher, K, Müller-Peltzer, H, Rübsamen, K, Heene, D L

“…Ancrod is a purified fraction of venom from the Malayan pit viper Calloselasma rhodostoma, containing a serine protease that cleaves fibrinopeptides A from…”
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Anticoagulation in patients with heparin-induced thrombocytopenia type II by Harenberg, J, Huhle, G, Piazolo, L, Wang, L U, Heene, D L

“…Heparin-induced thrombocytopenia (HIT) together with simultaneously occurring thromboembolism is a serious complication of heparin treatment. At present an…”
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Fibrin Formation and Proteolysis during Ancrod Treatment by DEMPFLE, CARL-ERIK, ARGIRIOU, SOTIRIA, ALESCI, SONJA, KUCHER, KLAUS, MÜLLER-PELTZER, H., RÜBSAMEN, KLAUS, HEENE, DIETER L.

“…: Ancrod is a purified fraction of venom from the Malayan pit viper Calloselasma rhodostoma, containing a serine protease that cleaves fibrinopeptides A from…”
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A New Therapeutic Option by Subcutaneous Recombinant Hirudin in Patients with Heparin-induced Thrombocytopenia Type II by Huhle, Günter, Hoffmann, Ursula, Hoffmann, Ines, Liebe, Volker, Harenberg, Job F, Heene, Dieter L

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Increase in platelet count in response to rHuEpo in a patient with thrombocytopenia and absent radii syndrome by Dempfle, Carl-Erik, Burck, Christine, Grützmacher, Tina, Wizenmann, Jan, Heene, Dieter L.

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Fibrin detected in plasma of patients with disseminated intravascular coagulation by fibrin-specific antibodies consists primarily of high molecular weight factor XIIIa-crosslinked and plasmin-modified complexes partially containing fibrinopeptide A by Pfitzner, S A, Dempfle, C E, Matsuda, M, Heene, D L

“…Pooled plasma from 40 patients with severe disseminated intravascular coagulation (DIC) secondary to septic conditions was subjected to gel permeation…”
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