Search Results - "Heemskerk, Mirjam HM"

SARS-CoV-2-specific CD4 + and CD8 + T cell responses can originate from cross-reactive CMV-specific T cells by Pothast, Cilia R, Dijkland, Romy C, Thaler, Melissa, Hagedoorn, Renate S, Kester, Michel G D, Wouters, Anne K, Hiemstra, Pieter S, van Hemert, Martijn J, Gras, Stephanie, Falkenburg, J H Frederik, Heemskerk, Mirjam H M

“…Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific CD4 and CD8 T cells in SARS-CoV-2-unexposed donors has been explained by the…”
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Generating HPV specific T helper cells for the treatment of HPV induced malignancies using TCR gene transfer by Scholten, Kirsten B J, Turksma, Annelies W, Ruizendaal, Janneke J, van den Hende, Muriel, van der Burg, Sjoerd H, Heemskerk, Mirjam H M, Meijer, Chris J L M, Hooijberg, Erik

“…Infection with high risk Human Papilloma Virus (HPV) is associated with cancer of the cervix, vagina, penis, vulva, anus and some cases of head and neck…”
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PRAME and HLA Class I expression patterns make synovial sarcoma a suitable target for PRAME specific T-cell receptor gene therapy by Luk, Sietse J, Steen, Dirk M van der, Hagedoorn, Renate S, Jordanova, Ekaterina S, Schilham, Marco W, Bovée, Judith VMG, Cleven, Arjen HG, Falkenburg, JH Frederik, Szuhai, Karoly, Heemskerk, Mirjam HM

“…Synovial sarcoma expresses multiple cancer testis antigens that could potentially be targeted by T-cell receptor (TCR) gene therapy. In this study we…”
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Toll‐like receptor 7/8‐matured RNA‐transduced dendritic cells as post‐remission therapy in acute myeloid leukaemia: results of a phase I trial by Lichtenegger, Felix S, Schnorfeil, Frauke M, Rothe, Maurine, Deiser, Katrin, Altmann, Torben, Bücklein, Veit L, Köhnke, Thomas, Augsberger, Christian, Konstandin, Nikola P, Spiekermann, Karsten, Moosmann, Andreas, Boehm, Stephan, Boxberg, Melanie, Heemskerk, Mirjam HM, Goerlich, Dennis, Wittmann, Georg, Wagner, Beate, Hiddemann, Wolfgang, Schendel, Dolores J, Kvalheim, Gunnar, Bigalke, Iris, Subklewe, Marion

“…Objectives Innovative post‐remission therapies are needed to eliminate residual AML cells. DC vaccination is a promising strategy to induce anti‐leukaemic…”
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Simultaneous Deletion of Endogenous TCRαβ for TCR Gene Therapy Creates an Improved and Safe Cellular Therapeutic by Morton, Laura T., Reijmers, Rogier M., Wouters, Anne K., Kweekel, Christiaan, Remst, Dennis F.G., Pothast, Cilia R., Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.

“…Generation of an optimal T cell therapeutic expressing high frequencies of transgenic T cell receptor (tgTCR) is essential for improving TCR gene therapy. Upon…”
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Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia by van der Lee, Dyantha I, Reijmers, Rogier M, Honders, Maria W, Hagedoorn, Renate S, de Jong, Rob Cm, Kester, Michel Gd, van der Steen, Dirk M, de Ru, Arnoud H, Kweekel, Christiaan, Bijen, Helena M, Jedema, Inge, Veelken, Hendrik, van Veelen, Peter A, Heemskerk, Mirjam Hm, Falkenburg, J H Frederik, Griffioen, Marieke

“…The most frequent subtype of acute myeloid leukemia (AML) is defined by mutations in the nucleophosmin 1 (NPM1) gene. Mutated NPM1 (ΔNPM1) is an attractive…”
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The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses by Jongsma, Marlieke L.M., de Waard, Antonius A., Raaben, Matthijs, Zhang, Tao, Cabukusta, Birol, Platzer, René, Blomen, Vincent A., Xagara, Anastasia, Verkerk, Tamara, Bliss, Sophie, Kong, Xiangrui, Gerke, Carolin, Janssen, Lennert, Stickel, Elmer, Holst, Stephanie, Plomp, Rosina, Mulder, Arend, Ferrone, Soldano, Claas, Frans H.J., Heemskerk, Mirjam H.M., Griffioen, Marieke, Halenius, Anne, Overkleeft, Hermen, Huppa, Johannes B., Wuhrer, Manfred, Brummelkamp, Thijn R., Neefjes, Jacques, Spaapen, Robbert M.

“…HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens to cognate CD8+ T cells. This process is often hijacked by tumors and pathogens…”
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Adoptive Immunotherapy Using PRAME-Specific T Cells in Medulloblastoma by Orlando, Domenico, Miele, Evelina, De Angelis, Biagio, Guercio, Marika, Boffa, Iolanda, Sinibaldi, Matilde, Po, Agnese, Caruana, Ignazio, Abballe, Luana, Carai, Andrea, Caruso, Simona, Camera, Antonio, Moseley, Annemarie, Hagedoorn, Renate S, Heemskerk, Mirjam H M, Giangaspero, Felice, Mastronuzzi, Angela, Ferretti, Elisabetta, Locatelli, Franco, Quintarelli, Concetta

“…Medulloblastoma is the most frequent malignant childhood brain tumor with a high morbidity. Identification of new therapeutic targets would be instrumental in…”
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Mixed T cell receptor dimers harbor potentially harmful neoreactivity by van Loenen, Marleen M., de Boer, Renate, Amir, Avital L., Hagedoorn, Renate S., Volbeda, Gerdien L., Willemze, Roelof, van Rood, Johannes J., Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.

“…Adoptive transfer of T cell receptor (TCR)-transduced T cells may be an attractive strategy to target both hematological malignancies and solid tumors. By…”
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Peripheral and systemic antigens elicit an expandable pool of resident memory CD8+ T cells in the bone marrow by Pascutti, Maria Fernanda, Geerman, Sulima, Collins, Nicholas, Brasser, Giso, Nota, Benjamin, Stark, Regina, Behr, Felix, Oja, Anna, Slot, Edith, Panagioti, Eleni, Prier, Julia E., Hickson, Sarah, Wolkers, Monika C., Heemskerk, Mirjam H.M., Hombrink, Pleun, Arens, Ramon, Mackay, Laura K., Gisbergen, Klaas P.J.M., Nolte, Martijn A.

“…BM has been put forward as a major reservoir for memory CD8+ T cells. In order to fulfill that function, BM should “store” memory CD8+ T cells, which in…”
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Preclinical Strategies to Identify Off-Target Toxicity of High-Affinity TCRs by Bijen, Helena M., van der Steen, Dirk M., Hagedoorn, Renate S., Wouters, Anne K., Wooldridge, Linda, Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.

“…Adoptive transfer of T cells engineered with a cancer-specific T cell receptor (TCR) has demonstrated clinical benefit. However, the risk for off-target…”
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The Human Leukocyte Antigen–presented Ligandome of B Lymphocytes by Hassan, Chopie, Kester, Michel G.D., de Ru, Arnoud H., Hombrink, Pleun, Drijfhout, Jan Wouter, Nijveen, Harm, Leunissen, Jack A.M., Heemskerk, Mirjam H.M., Falkenburg, J.H. Frederik, van Veelen, Peter A.

“…Peptides presented by human leukocyte antigen (HLA) molecules on the cell surface play a crucial role in adaptive immunology, mediating the communication…”
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CLEC12A-Mediated Antigen Uptake and Cross-Presentation by Human Dendritic Cell Subsets Efficiently Boost Tumor-Reactive T Cell Responses by Hutten, Tim J A, Thordardottir, Soley, Fredrix, Hanny, Janssen, Lisanne, Woestenenk, Rob, Tel, Jurjen, Joosten, Ben, Cambi, Alessandra, Heemskerk, Mirjam H M, Franssen, Gerben M, Boerman, Otto C, Bakker, Lex B H, Jansen, Joop H, Schaap, Nicolaas, Dolstra, Harry, Hobo, Willemijn

“…Potent immunotherapies are urgently needed to boost antitumor immunity and control disease in cancer patients. As dendritic cells (DCs) are the most powerful…”
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PRAME-Specific Allo-HLA―Restricted T Cells with Potent Antitumor Reactivity Useful for Therapeutic T-Cell Receptor Gene Transfer by AMIR, Avital L, VAN DER STEEN, Dirk M, JEDEMA, Inge, GRIFFIOEN, Marieke, VAN VEELEN, Peter A, FALKENBURG, J. H. Frederik, HEEMSKERK, Mirjam H. M, VAN LOENEN, Marleen M, HAGEDOORN, Renate S, DE BOER, Renate, KESTER, Michel D. G, DE RU, Arnoud H, LUGTHART, Gert-Jan, VAN KOOTEN, Cees, HIEMSTRA, Pieter S

“…In human leukocyte antigen (HLA)-matched stem cell transplantation (SCT), it has been shown that beneficial immune response mediating graft-versus-tumor (GVT)…”
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Abstract LB-084: Go-TCR: Inducible MyD88CD40 (iMC) enhances proliferation and survival of tumor-specific TCR-modified T cells, increasing anti-tumor efficacy by Spencer, David M, Hoang, Tsvetelina P, Foster, Aaron, Rodriguez, Tania, Torres, David, Lu, An, Crisostomo, Jeannette, Jahn, Lorenz, Heemskerk, Mirjam HM

“…Introduction: Use of tumor antigen-specific T cell receptors (TCRs) to refocus T cell killing has shown tantalizing clinical efficacy; however, durable…”
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Abstract 3745: Dual-switch TCR: A two-ligand system to control PRAME TCR-modified T cell proliferation and death using inducible MyD88/CD40 and caspase-9 by Pentcheva-Hoang, Tsvetelina, Rodriguez, Tania, Torres, David, Korngold, Ana, Crisostomo, Jeannette, Duong, MyLinh T., Collinson-Pautz, Matthew, Bayle, J. Henri, Heemskerk, Mirjam HM, Falkenburg, J.H. Frederik, Moseley, Annemarie, Slawin, Kevin M., Spencer, David, Foster, Aaron E.

“…Abstract T cells engineered to express the α and β chains of antigen-specific T cell receptors (TCRs) have shown promise as a cancer immunotherapy treatment;…”
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Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7 by Bakker, Arnold H, Hoppes, Rieuwert, Linnemann, Carsten, Toebes, Mireille, Rodenko, Boris, Berkers, Celia R, Hadrup, Sine Reker, van Esch, Wim J.E, Heemskerk, Mirjam H.M, Ovaa, Huib, Schumacher, Ton N.M

“…Major histocompatibility complex (MHC) class I multimer technology has become an indispensable immunological assay system to dissect antigen-specific cytotoxic…”
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The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells by Gram, Anna M, Oosenbrug, Timo, Lindenbergh, Marthe F S, Büll, Christian, Comvalius, Anouskha, Dickson, Kathryn J I, Wiegant, Joop, Vrolijk, Hans, Lebbink, Robert Jan, Wolterbeek, Ron, Adema, Gosse J, Griffioen, Marieke, Heemskerk, Mirjam H M, Tscharke, David C, Hutt-Fletcher, Lindsey M, Wiertz, Emmanuel J H J, Hoeben, Rob C, Ressing, Maaike E

“…Cell-mediated immunity plays a key role in host control of viral infection. This is exemplified by life-threatening reactivations of e.g. herpesviruses in…”
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Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen by de Mare-Bredemeijer, Emmy L D, Shi, Xiao-lei, Mancham, Shanta, van Gent, Rogier, van der Heide-Mulder, Marieke, de Boer, Renate, Heemskerk, Mirjam H M, de Jonge, Jeroen, van der Laan, Luc J W, Metselaar, Herold J, Kwekkeboom, Jaap

“…The chronic presence of viral Ags can induce T cell exhaustion, which is characterized by upregulation of coinhibitory receptors and loss of T cell function…”
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Discovery of T cell epitopes implementing HLA-peptidomics into a reverse immunology approach by Hombrink, Pleun, Hassan, Chopie, Kester, Michel G D, de Ru, Arnoud H, van Bergen, Cornelis A M, Nijveen, Harm, Drijfhout, Jan W, Falkenburg, J H Frederik, Heemskerk, Mirjam H M, van Veelen, Peter A

“…T cell recognition of minor histocompatibility Ags (MiHA) plays an important role in the graft-versus-tumor effect of allogeneic stem cell transplantation…”
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