Search Results - "Heemskerk, Mirjam"

Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia by van der Lee, Dyantha I, Reijmers, Rogier M, Honders, Maria W, Hagedoorn, Renate S, de Jong, Rob Cm, Kester, Michel Gd, van der Steen, Dirk M, de Ru, Arnoud H, Kweekel, Christiaan, Bijen, Helena M, Jedema, Inge, Veelken, Hendrik, van Veelen, Peter A, Heemskerk, Mirjam Hm, Falkenburg, J H Frederik, Griffioen, Marieke

“…The most frequent subtype of acute myeloid leukemia (AML) is defined by mutations in the nucleophosmin 1 (NPM1) gene. Mutated NPM1 (ΔNPM1) is an attractive…”
Get full text

The SPPL3-Defined Glycosphingolipid Repertoire Orchestrates HLA Class I-Mediated Immune Responses by Jongsma, Marlieke L.M., de Waard, Antonius A., Raaben, Matthijs, Zhang, Tao, Cabukusta, Birol, Platzer, René, Blomen, Vincent A., Xagara, Anastasia, Verkerk, Tamara, Bliss, Sophie, Kong, Xiangrui, Gerke, Carolin, Janssen, Lennert, Stickel, Elmer, Holst, Stephanie, Plomp, Rosina, Mulder, Arend, Ferrone, Soldano, Claas, Frans H.J., Heemskerk, Mirjam H.M., Griffioen, Marieke, Halenius, Anne, Overkleeft, Hermen, Huppa, Johannes B., Wuhrer, Manfred, Brummelkamp, Thijn R., Neefjes, Jacques, Spaapen, Robbert M.

“…HLA class I (HLA-I) glycoproteins drive immune responses by presenting antigens to cognate CD8+ T cells. This process is often hijacked by tumors and pathogens…”
Get full text

Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells by Anadon, Carmen M., Yu, Xiaoqing, Hänggi, Kay, Biswas, Subir, Chaurio, Ricardo A., Martin, Alexandra, Payne, Kyle K., Mandal, Gunjan, Innamarato, Patrick, Harro, Carly M., Mine, Jessica A., Sprenger, Kimberly B., Cortina, Carla, Powers, John J., Costich, Tara Lee, Perez, Bradford A., Gatenbee, Chandler D., Prabhakaran, Sandhya, Marchion, Douglas, Heemskerk, Mirjam H.M., Curiel, Tyler J., Anderson, Alexander R., Wenham, Robert M., Rodriguez, Paulo C., Conejo-Garcia, Jose R.

“…Despite repeated associations between T cell infiltration and outcome, human ovarian cancer remains poorly responsive to immunotherapy. We report that the…”
Get full text

PRAME as a Potential Target for Immunotherapy in Metastatic Uveal Melanoma by Gezgin, Gülçin, Luk, Sietse J, Cao, Jinfeng, Dogrusöz, Mehmet, van der Steen, Dirk M, Hagedoorn, Renate S, Krijgsman, Daniëlle, van der Velden, Pieter A, Field, Matthew G, Luyten, Gregorius P M, Szuhai, Karoly, Harbour, J William, Jordanova, Ekaterina S, Heemskerk, Mirjam H M, Jager, Martine J

“…Uveal melanoma (UM) is an intraocular primary malignant neoplasm that often gives rise to metastatic disease for which there are no effective therapies. A…”
Get more information

Inhibition of SUMOylation enhances DNA hypomethylating drug efficacy to reduce outgrowth of hematopoietic malignancies by Kroonen, Jessie S., de Graaf, Ilona J., Kumar, Sumit, Remst, Dennis F. G., Wouters, Anne K., Heemskerk, Mirjam H. M., Vertegaal, Alfred C. O.

“…Combination therapies targeting malignancies aim to increase treatment efficacy and reduce toxicity. Hypomethylating drug 5-Aza-2’-deoxycytidine (5-Aza-2’)…”
Get full text

Allo-HLA reactivity of virus-specific memory T cells is common by Amir, Avital L, D'Orsogna, Lloyd J.A, Roelen, Dave L, van Loenen, Marleen M, Hagedoorn, Renate S, de Boer, Renate, van der Hoorn, Menno A.W.G, Kester, Michel G.D, Doxiadis, Ilias I.N, Falkenburg, J. H. Frederik, Claas, Frans H.J, Heemskerk, Mirjam H.M

“…Graft-versus-host disease and graft rejection are major complications of allogeneic HLA-mismatched stem cell transplantation or organ transplantation that are…”
Get full text

Reassessing human MHC-I genetic diversity in T cell studies by Slieker, Roderick C., Warmerdam, Daniël O., Vermeer, Maarten H., van Doorn, Remco, Heemskerk, Mirjam H. M., Scheeren, Ferenc A.

“…The Major Histocompatibility Complex class I (MHC-I) system plays a vital role in immune responses by presenting antigens to T cells. Allele specific…”
Get full text

Adoptive Immunotherapy Using PRAME-Specific T Cells in Medulloblastoma by Orlando, Domenico, Miele, Evelina, De Angelis, Biagio, Guercio, Marika, Boffa, Iolanda, Sinibaldi, Matilde, Po, Agnese, Caruana, Ignazio, Abballe, Luana, Carai, Andrea, Caruso, Simona, Camera, Antonio, Moseley, Annemarie, Hagedoorn, Renate S, Heemskerk, Mirjam H M, Giangaspero, Felice, Mastronuzzi, Angela, Ferretti, Elisabetta, Locatelli, Franco, Quintarelli, Concetta

“…Medulloblastoma is the most frequent malignant childhood brain tumor with a high morbidity. Identification of new therapeutic targets would be instrumental in…”
Get full text

Characterization of circulating T-, NK-, and NKT cell subsets in patients with colorectal cancer: the peripheral blood immune cell profile by Krijgsman, Daniëlle, de Vries, Natasja L., Skovbo, Anni, Andersen, Morten N., Swets, Marloes, Bastiaannet, Esther, Vahrmeijer, Alexander L., van de Velde, Cornelis J. H., Heemskerk, Mirjam H. M., Hokland, Marianne, Kuppen, Peter J. K.

“…Objective As the development and progression of colorectal cancer (CRC) are known to be affected by the immune system, cell subsets such as T cells, natural…”
Get full text

TCR targeting hematopoiesis to cure leukemia by Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.

Get full text

High-throughput identification of antigen-specific TCRs by TCR gene capture by Linnemann, Carsten, Heemskerk, Bianca, Kvistborg, Pia, Kluin, Roelof J C, Bolotin, Dmitriy A, Chen, Xiaojing, Bresser, Kaspar, Nieuwland, Marja, Schotte, Remko, Michels, Samira, Gomez-Eerland, Raquel, Jahn, Lorenz, Hombrink, Pleun, Legrand, Nicolas, Shu, Chengyi Jenny, Mamedov, Ilgar Z, Velds, Arno, Blank, Christian U, Haanen, John B A G, Turchaninova, Maria A, Kerkhoven, Ron M, Spits, Hergen, Hadrup, Sine Reker, Heemskerk, Mirjam H M, Blankenstein, Thomas, Chudakov, Dmitriy M, Bendle, Gavin M, Schumacher, Ton N M

“…The lack of robust and high-throughput technologies to analyze the human TCR repertoire has been a bottleneck in the analysis of human T cell responses…”
Get full text

Selective graft-versus-leukemia depends on magnitude and diversity of the alloreactive T cell response by van Bergen, Cornelis A M, van Luxemburg-Heijs, Simone A P, de Wreede, Liesbeth C, Eefting, Matthijs, von dem Borne, Peter A, van Balen, Peter, Heemskerk, Mirjam H M, Mulder, Arend, Claas, Fransiscus H J, Navarrete, Marcelo A, Honders, Wilhelmina M, Rutten, Caroline E, Veelken, Hendrik, Jedema, Inge, Halkes, Constantijn J M, Griffioen, Marieke, Falkenburg, J H Frederik

“…Patients with leukemia who receive a T cell-depleted allogeneic stem cell graft followed by postponed donor lymphocyte infusion (DLI) can experience…”
Get full text

Mixed T cell receptor dimers harbor potentially harmful neoreactivity by van Loenen, Marleen M., de Boer, Renate, Amir, Avital L., Hagedoorn, Renate S., Volbeda, Gerdien L., Willemze, Roelof, van Rood, Johannes J., Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.

“…Adoptive transfer of T cell receptor (TCR)-transduced T cells may be an attractive strategy to target both hematological malignancies and solid tumors. By…”
Get full text

Chimeric autoantibody receptor cell therapy for the treatment of membranous nephropathy by Rovira, Jordi, Arana, Carolt, Garcia-Busquets, Ainhoa, Gille, Ilse, Quintana, Luís F, Heemskerk, Mirjam H M, Heidt, Sebastiaan, Palou, Eduard, Diekmann, Fritz

Get more information

Simultaneous Deletion of Endogenous TCRαβ for TCR Gene Therapy Creates an Improved and Safe Cellular Therapeutic by Morton, Laura T., Reijmers, Rogier M., Wouters, Anne K., Kweekel, Christiaan, Remst, Dennis F.G., Pothast, Cilia R., Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.

“…Generation of an optimal T cell therapeutic expressing high frequencies of transgenic T cell receptor (tgTCR) is essential for improving TCR gene therapy. Upon…”
Get full text

Preclinical Strategies to Identify Off-Target Toxicity of High-Affinity TCRs by Bijen, Helena M., van der Steen, Dirk M., Hagedoorn, Renate S., Wouters, Anne K., Wooldridge, Linda, Falkenburg, J.H. Frederik, Heemskerk, Mirjam H.M.

“…Adoptive transfer of T cells engineered with a cancer-specific T cell receptor (TCR) has demonstrated clinical benefit. However, the risk for off-target…”
Get full text

Identification of non-mutated neoantigens presented by TAP-deficient tumors by Marijt, Koen A, Blijleven, Laura, Verdegaal, Els M E, Kester, Michel G, Kowalewski, Daniel J, Rammensee, Hans-Georg, Stevanović, Stefan, Heemskerk, Mirjam H M, van der Burg, Sjoerd H, van Hall, Thorbald

“…Most T cell-based immunotherapies of cancer depend on intact antigen presentation by HLA class I molecules (HLA-I). However, defects in the antigen-processing…”
Get full text

SARS-CoV-2-specific CD4 + and CD8 + T cell responses can originate from cross-reactive CMV-specific T cells by Pothast, Cilia R, Dijkland, Romy C, Thaler, Melissa, Hagedoorn, Renate S, Kester, Michel G D, Wouters, Anne K, Hiemstra, Pieter S, van Hemert, Martijn J, Gras, Stephanie, Falkenburg, J H Frederik, Heemskerk, Mirjam H M

“…Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific CD4 and CD8 T cells in SARS-CoV-2-unexposed donors has been explained by the…”
Get full text

Human CD34+-derived complete plasmacytoid and conventional dendritic cell vaccine effectively induces antigen-specific CD8+ T cell and NK cell responses in vitro and in vivo by van Eck van der Sluijs, Jesper, van Ens, Diede, Brummelman, Jolanda, Heister, Daan, Sareen, Aastha, Truijen, Lisa, van Ingen Schenau, Dorette S., Heemskerk, Mirjam H. M., Griffioen, Marieke, Kester, Michel G. D., Schaap, Nicolaas P. M., Jansen, Joop H., van der Waart, Anniek B., Dolstra, Harry, Hobo, Willemijn

“…Allogeneic stem cell transplantation (alloSCT) can be curative for hemato-oncology patients due to effective graft-versus-tumor immunity. However, relapse…”
Get full text

Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function by Thomas, Sharyn, Mohammed, Fiyaz, Reijmers, Rogier M., Woolston, Annemarie, Stauss, Theresa, Kennedy, Alan, Stirling, David, Holler, Angelika, Green, Louisa, Jones, David, Matthews, Katherine K., Price, David A., Chain, Benjamin M., Heemskerk, Mirjam H. M., Morris, Emma C., Willcox, Benjamin E., Stauss, Hans J.

“…TCR-gene-transfer is an efficient strategy to produce therapeutic T cells of defined antigen specificity. However, there are substantial variations in the cell…”
Get full text