Search Results - "Heemskerk, Mattijs M."

Prolonged niacin treatment leads to increased adipose tissue PUFA synthesis and anti-inflammatory lipid and oxylipin plasma profile[S] by Heemskerk, Mattijs M., Dharuri, Harish K., van den Berg, Sjoerd A.A., Jónasdóttir, Hulda S., Kloos, Dick-Paul, Giera, Martin, van Dijk, Ko Willems, van Harmelen, Vanessa

“…Prolonged niacin treatment elicits beneficial effects on the plasma lipid and lipoprotein profile that is associated with a protective CVD risk profile. Acute…”
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Salsalate activates brown adipose tissue in mice by van Dam, Andrea D, Nahon, Kimberly J, Kooijman, Sander, van den Berg, Susan M, Kanhai, Anish A, Kikuchi, Takuya, Heemskerk, Mattijs M, van Harmelen, Vanessa, Lombès, Marc, van den Hoek, Anita M, de Winther, Menno P J, Lutgens, Esther, Guigas, Bruno, Rensen, Patrick C N, Boon, Mariëtte R

“…Salsalate improves glucose intolerance and dyslipidemia in type 2 diabetes patients, but the mechanism is still unknown. The aim of the current study was to…”
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Increased PUFA Content and 5-Lipoxygenase Pathway Expression Are Associated with Subcutaneous Adipose Tissue Inflammation in Obese Women with Type 2 Diabetes by Heemskerk, Mattijs M, Giera, Martin, Bouazzaoui, Fatiha El, Lips, Mirjam A, Pijl, Hanno, van Dijk, Ko Willems, van Harmelen, Vanessa

“…Obese women with type 2 diabetes mellitus (T2DM) have more inflammation in their subcutaneous white adipose tissue (sWAT) than age-and-BMI similar obese women…”
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Niacin Reduces Atherosclerosis Development in APOE3Leiden.CETP Mice Mainly by Reducing NonHDL-Cholesterol by Kühnast, Susan, Louwe, Mieke C, Heemskerk, Mattijs M, Pieterman, Elsbet J, van Klinken, Jan B, van den Berg, Sjoerd A A, Smit, Johannes W A, Havekes, Louis M, Rensen, Patrick C N, van der Hoorn, José W A, Princen, Hans M G, Jukema, J Wouter

“…Niacin potently lowers triglycerides, mildly decreases LDL-cholesterol, and largely increases HDL-cholesterol. Despite evidence for an atheroprotective effect…”
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Effects of low-stearate palm oil and high-stearate lard high-fat diets on rat liver lipid metabolism and glucose tolerance by Janssens, Sharon, Heemskerk, Mattijs M, van den Berg, Sjoerd A, van Riel, Natal A, Nicolay, Klaas, Willems van Dijk, Ko, Prompers, Jeanine J

“…Excess consumption of energy-dense, high-fat Western diets contributes to the development of obesity and obesity-related disorders, such as fatty liver…”
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Chronic helminth infection and helminth‐derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice by Hussaarts, Leonie, García‐Tardón, Noemí, Beek, Lianne, Heemskerk, Mattijs M., Haeberlein, Simone, Zon, Gerard C., Ozir‐Fazalalikhan, Arifa, Berbée, Jimmy F. P., Dijk, Ko Willems, Harmelen, Vanessa, Yazdanbakhsh, Maria, Guigas, Bruno

“…ABSTRACT Chronic low‐grade inflammation associated with obesity contributes to insulin resistance and type 2 diabetes. Helminth parasites are the strongest…”
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Reanalysis of mGWAS results and in vitro validation show that lactate dehydrogenase interacts with branched-chain amino acid metabolism by Heemskerk, Mattijs M, van Harmelen, Vanessa J A, van Dijk, Ko Willems, van Klinken, Jan Bert

“…The assignment of causative genes to noncoding variants identified in genome-wide association studies (GWASs) is challenging. We show how combination of…”
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FcRγ‐chain deficiency reduces the development of diet‐induced obesity by van Beek, Lianne, Vroegrijk, Irene O.C.M., Katiraei, Saeed, Heemskerk, Mattijs M., van Dam, Andrea D., Kooijman, Sander, Rensen, Patrick C.N., Koning, Frits, Verbeek, J. Sjef, Willems van Dijk, Ko, van Harmelen, Vanessa

“…Objective Pathogenic immunoglobulins are produced during the development of obesity and contribute to the development of insulin resistance (IR). However, the…”
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Long-term niacin treatment induces insulin resistance and adrenergic responsiveness in adipocytes by adaptive downregulation of phosphodiesterase 3B by Heemskerk, Mattijs M, van den Berg, Sjoerd A A, Pronk, Amanda C M, van Klinken, Jan-Bert, Boon, Mariëtte R, Havekes, Louis M, Rensen, Patrick C N, van Dijk, Ko Willems, van Harmelen, Vanessa

“…The lipid-lowering effect of niacin has been attributed to the inhibition of cAMP production in adipocytes, thereby inhibiting intracellular lipolysis and…”
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Apolipoprotein A5 deficiency aggravates high‐fat diet‐induced obesity due to impaired central regulation of food intake by Berg, Sjoerd A. A., Heemskerk, Mattijs M., Geerling, Janine J., Klinken, Jan‐Bert, Schaap, Frank G., Bijland, Silvia, Berbée, Jimmy F. P., Harmelen, Vanessa J. A., Pronk, Amanda C. M, Schreurs, Marijke, Havekes, Louis M., Rensen, Patrick C. N, Dijk, Ko Willems

“…Mutations in apolipoprotein A5 (APOA5) have been associated with hypertriglyceridemia in humans and mice. This has been attributed to a stimulating role for…”
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Protein-induced geometric constraints and charge transfer in bacteriochlorophyll-histidine complexes in LH2 by Wawrzyniak, Piotr K, Alia, A, Schaap, Roland G, Heemskerk, Mattijs M, de Groot, Huub J M, Buda, Francesco

“…Bacteriochlorophyll-histidine complexes are ubiquitous in nature and are essential structural motifs supporting the conversion of solar energy into chemically…”
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F c R γ‐chain deficiency reduces the development of diet‐induced obesity by van Beek, Lianne, Vroegrijk, Irene O.C.M., Katiraei, Saeed, Heemskerk, Mattijs M., van Dam, Andrea D., Kooijman, Sander, Rensen, Patrick C.N., Koning, Frits, Verbeek, J. Sjef, Willems van Dijk, Ko, van Harmelen, Vanessa

“…Objective Pathogenic immunoglobulins are produced during the development of obesity and contribute to the development of insulin resistance (IR). However, the…”
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FcR[gamma]-Chain Deficiency Reduces the Development of Diet-Induced Obesity by van Beek, Lianne, Vroegrijk, Irene O C M, Katiraei, Saeed, Heemskerk, Mattijs M, van Dam, Andrea D, Kooijman, Sander, Rensen, Patrick C N, Koning, Frits, Verbeek, J Sjef, van Dijk, Ko Willems, van Harmelen, Vanessa

“…Pathogenic immunoglobulins are produced during the development of obesity and contribute to the development of insulin resistance (IR). However, the mechanisms…”
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PS13 - 5. Protective effect of chronic helminth infection against diet-induced obesity by Guigas, Bruno, Hussaarts, Leonie, van Beek, Lianne, Heemskerk, Mattijs M., Haeberlein, Simone, Berbee, Jimmy F., van Harmelen, Vanessa, van Dijk, Ko Willems, Yazdanbakhsh, Maria

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PS13 - 1. APOA5 plays a role in high-fat diet induced inflammation by Heemskerk, Mattijs M., van Beek, Lianne, Pronk, Amanda, van den Berg, Sjoerd A.A., Lips, Mirjam A., Schaap, Frank G., van Dijk, Ko Willems, van Harmelen, Vanessa J.A.

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