Search Results - "Heemskerk, M. H. M."

Reassessing human MHC-I genetic diversity in T cell studies by Slieker, Roderick C., Warmerdam, Daniël O., Vermeer, Maarten H., van Doorn, Remco, Heemskerk, Mirjam H. M., Scheeren, Ferenc A.

“…The Major Histocompatibility Complex class I (MHC-I) system plays a vital role in immune responses by presenting antigens to T cells. Allele specific…”
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Antibody-epitope conjugates deliver immunogenic T-cell epitopes more efficiently when close to cell surfaces by van der Wulp, W, Luu, W, Ressing, M E, Schuurman, J, van Kasteren, S I, Guelen, L, Hoeben, R C, Bleijlevens, B, Heemskerk, M H M

“…Antibody-mediated delivery of immunogenic viral CD8 T-cell epitopes to redirect virus-specific T cells toward cancer cells is a promising new therapeutic…”
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Mixed T cell receptor dimers harbor potentially harmful neoreactivity by van Loenen, Marleen M., de Boer, Renate, Amir, Avital L., Hagedoorn, Renate S., Volbeda, Gerdien L., Willemze, Roelof, van Rood, Johannes J., Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.

“…Adoptive transfer of T cell receptor (TCR)-transduced T cells may be an attractive strategy to target both hematological malignancies and solid tumors. By…”
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SARS-CoV-2-specific CD4 + and CD8 + T cell responses can originate from cross-reactive CMV-specific T cells by Pothast, Cilia R, Dijkland, Romy C, Thaler, Melissa, Hagedoorn, Renate S, Kester, Michel G D, Wouters, Anne K, Hiemstra, Pieter S, van Hemert, Martijn J, Gras, Stephanie, Falkenburg, J H Frederik, Heemskerk, Mirjam H M

“…Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) specific CD4 and CD8 T cells in SARS-CoV-2-unexposed donors has been explained by the…”
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PRAME-Specific Allo-HLA―Restricted T Cells with Potent Antitumor Reactivity Useful for Therapeutic T-Cell Receptor Gene Transfer by AMIR, Avital L, VAN DER STEEN, Dirk M, JEDEMA, Inge, GRIFFIOEN, Marieke, VAN VEELEN, Peter A, FALKENBURG, J. H. Frederik, HEEMSKERK, Mirjam H. M, VAN LOENEN, Marleen M, HAGEDOORN, Renate S, DE BOER, Renate, KESTER, Michel D. G, DE RU, Arnoud H, LUGTHART, Gert-Jan, VAN KOOTEN, Cees, HIEMSTRA, Pieter S

“…In human leukocyte antigen (HLA)-matched stem cell transplantation (SCT), it has been shown that beneficial immune response mediating graft-versus-tumor (GVT)…”
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Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7 by Bakker, Arnold H, Hoppes, Rieuwert, Linnemann, Carsten, Toebes, Mireille, Rodenko, Boris, Berkers, Celia R, Hadrup, Sine Reker, van Esch, Wim J.E, Heemskerk, Mirjam H.M, Ovaa, Huib, Schumacher, Ton N.M

“…Major histocompatibility complex (MHC) class I multimer technology has become an indispensable immunological assay system to dissect antigen-specific cytotoxic…”
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T helper 2 response in allergic bronchopulmonary aspergillosis is not driven by specific Aspergillus antigens by Jolink, H., Boer, R., Willems, L. N. A., Dissel, J. T., Falkenburg, J. H. F., Heemskerk, M. H. M.

“…Allergic bronchopulmonary aspergillosis (ABPA) is characterized by an allergic immunological response to Aspergillus fumigatus. In this study, we investigated…”
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Gamma-Ray Burst Afterglows as Probes of Environment and Blast Wave Physics. I. Absorption by Host-Galaxy Gas and Dust by Starling, R. L. C, Wijers, R. A. M. J, Wiersema, K, Rol, E, Curran, P. A, Kouveliotou, C, van der Horst, A. J, Heemskerk, M. H. M

“…We use a new approach to obtain limits on the absorbing columns toward an initial sample of 10 long gamma-ray bursts observed with BeppoSAX and selected on the…”
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The Epstein-Barr Virus Glycoprotein gp150 Forms an Immune-Evasive Glycan Shield at the Surface of Infected Cells by Gram, Anna M, Oosenbrug, Timo, Lindenbergh, Marthe F S, Büll, Christian, Comvalius, Anouskha, Dickson, Kathryn J I, Wiegant, Joop, Vrolijk, Hans, Lebbink, Robert Jan, Wolterbeek, Ron, Adema, Gosse J, Griffioen, Marieke, Heemskerk, Mirjam H M, Tscharke, David C, Hutt-Fletcher, Lindsey M, Wiertz, Emmanuel J H J, Hoeben, Rob C, Ressing, Maaike E

“…Cell-mediated immunity plays a key role in host control of viral infection. This is exemplified by life-threatening reactivations of e.g. herpesviruses in…”
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Framework engineering to produce dominant T cell receptors with enhanced antigen-specific function by Thomas, Sharyn, Mohammed, Fiyaz, Reijmers, Rogier M., Woolston, Annemarie, Stauss, Theresa, Kennedy, Alan, Stirling, David, Holler, Angelika, Green, Louisa, Jones, David, Matthews, Katherine K., Price, David A., Chain, Benjamin M., Heemskerk, Mirjam H. M., Morris, Emma C., Willcox, Benjamin E., Stauss, Hans J.

“…TCR-gene-transfer is an efficient strategy to produce therapeutic T cells of defined antigen specificity. However, there are substantial variations in the cell…”
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Immunogenicity and reactogenicity of intradermal mRNA-1273 SARS-CoV-2 vaccination: a non-inferiority, randomized-controlled trial by Prins, Manon L. M., Roozen, Geert V. T., Pothast, Cilia. R., Huisman, Wesley, van Binnendijk, Rob, den Hartog, Gerco, Kuiper, Vincent P., Prins, Corine, Janse, Jacqueline J., Lamers, Olivia. A. C., Koopman, Jan Pieter R., Kruithof, Annelieke C., Kamerling, Ingrid M. C., Dijkland, Romy C., de Kroon, Alicia. C., Azimi, Shohreh, Feltkamp, Mariet C. W., Kuijer, Marjan, Jochems, Simon P., Heemskerk, Mirjam H. M., Rosendaal, Frits R., Roestenberg, Meta, Visser, Leo G., Roukens, Anna H. E.

“…Fractional dosing can be a cost-effective vaccination strategy to accelerate individual and herd immunity in a pandemic. We assessed the immunogenicity and…”
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High-throughput identification of potential minor histocompatibility antigens by MHC tetramer-based screening: feasibility and limitations by Hombrink, Pleun, Hadrup, Sine R, Bakker, Arne, Kester, Michel G D, Falkenburg, J H Frederik, von dem Borne, Peter A, Schumacher, Ton N M, Heemskerk, Mirjam H M

“…T-cell recognition of minor histocompatibility antigens (MiHA) plays an important role in the graft-versus-tumor (GVT) effect of allogeneic stem cell…”
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In vitro generation of mature, naive antigen-specific CD8+ T cells with a single T-cell receptor by agonist selection by Snauwaert, S, Verstichel, G, Bonte, S, Goetgeluk, G, Vanhee, S, Van Caeneghem, Y, De Mulder, K, Heirman, C, Stauss, H, Heemskerk, M H M, Taghon, T, Leclercq, G, Plum, J, Langerak, A W, Thielemans, K, Kerre, T, Vandekerckhove, B

“…Peripheral blood T cells transduced with a tumor-specific T-cell receptor (TCR) face problems of auto-reactivity and lack of efficacy caused by cross-pairing…”
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High-throughput identification of antigen-specific TCRs by TCR gene capture by Linnemann, Carsten, Heemskerk, Bianca, Kvistborg, Pia, Kluin, Roelof J C, Bolotin, Dmitriy A, Chen, Xiaojing, Bresser, Kaspar, Nieuwland, Marja, Schotte, Remko, Michels, Samira, Gomez-Eerland, Raquel, Jahn, Lorenz, Hombrink, Pleun, Legrand, Nicolas, Shu, Chengyi Jenny, Mamedov, Ilgar Z, Velds, Arno, Blank, Christian U, Haanen, John B A G, Turchaninova, Maria A, Kerkhoven, Ron M, Spits, Hergen, Hadrup, Sine Reker, Heemskerk, Mirjam H M, Blankenstein, Thomas, Chudakov, Dmitriy M, Bendle, Gavin M, Schumacher, Ton N M

“…The lack of robust and high-throughput technologies to analyze the human TCR repertoire has been a bottleneck in the analysis of human T cell responses…”
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Comparing CAR and TCR engineered T cell performance as a function of tumor cell exposure by Wachsmann, Tassilo L. A., Wouters, Anne K., Remst, Dennis F. G., Hagedoorn, Renate S., Meeuwsen, Miranda H., van Diest, Eline, Leusen, Jeanette, Kuball, Jürgen, Falkenburg, J. H. Frederik, Heemskerk, Mirjam H. M.

“…Chimeric antigen receptor (CAR) T cell therapies have resulted in profound clinical responses in the treatment of CD19-positive hematological malignancies, but…”
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Chimeric Antigen Receptor (CAR) Regulatory T-Cells in Solid Organ Transplantation by Gille, Ilse, Claas, Frans H. J., Haasnoot, Geert W., Heemskerk, Mirjam H. M., Heidt, Sebastiaan

“…Solid organ transplantation is the treatment of choice for various end-stage diseases, but requires the continuous need for immunosuppression to prevent…”
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Transduction of human T cells with a novel T-cell receptor confers anti-HCV reactivity by Zhang, Yi, Liu, Yeuying, Moxley, Kelly M, Golden-Mason, Lucy, Hughes, Michael G, Liu, Tongxin, Heemskerk, Mirjam H M, Rosen, Hugo R, Nishimura, Michael I

“…Hepatitis C Virus (HCV) is a major public health concern, with no effective vaccines currently available and 3% of the world's population being infected…”
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HLA-DP as specific target for cellular immunotherapy in HLA class II-expressing B-cell leukemia by Rutten, C E, van Luxemburg-Heijs, S A P, Griffioen, M, Marijt, E W A, Jedema, I, Heemskerk, M H M, Posthuma, E F M, Willemze, R, Falkenburg, J H F

“…Mismatching for human leukocyte antigen (HLA)-DPB1 in unrelated donor hematopoietic stem cell transplantation (URD-SCT) has been associated with a decreased…”
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Optimization of the HA-1-specific T-cell receptor for gene therapy of hematologic malignancies by VAN LOENEN, Marleen M, DE BOER, Renate, HAGEDOORN, Renate S, VAN EGMOND, Esther H. M, FREDERIK FALKENBURG, J. H, HEEMSKERK, Mirjam H. M

“…To broaden the applicability of adoptive T-cell therapy for the treatment of hematologic malignancies, we aim to start a clinical trial using HA-1-TCR…”
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PRAME as a Potential Target for Immunotherapy in Metastatic Uveal Melanoma by Gezgin, Gülçin, Luk, Sietse J, Cao, Jinfeng, Dogrusöz, Mehmet, van der Steen, Dirk M, Hagedoorn, Renate S, Krijgsman, Daniëlle, van der Velden, Pieter A, Field, Matthew G, Luyten, Gregorius P M, Szuhai, Karoly, Harbour, J William, Jordanova, Ekaterina S, Heemskerk, Mirjam H M, Jager, Martine J

“…Uveal melanoma (UM) is an intraocular primary malignant neoplasm that often gives rise to metastatic disease for which there are no effective therapies. A…”
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