Vitamin D levels and cytokine profiles in patients with systemic lupus erythematosus

Objectives To evaluate the expression of Th1, Th2, and Th17 cytokines in patients with systemic lupus erythematosus (SLE), and verify the association between serum cytokine levels and vitamin D concentration. Methods The sample consisted of 172 patients with SLE. 25-Hydroxyvitamin D (25(OH)D) levels...

Full description

Saved in:

Bibliographic Details
Published in:	Lupus Vol. 24; no. 11; pp. 1191 - 1197
Main Authors:	Schneider, L, Colar da Silva, A C, Werres Junior, L C, Alegretti, A P, dos Santos, A S Pereira, Santos, M, Sassi, R, Heemann, B, Pfaffenseller, B, Tavares Brenol, J C, Monticielo, O A
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-10-2015 Sage Publications Ltd
Subjects:	Adult Cross-Sectional Studies Cytokines Cytokines - blood Cytokines - metabolism Dendritic cells Disease Female Flow Cytometry - methods Hospitals Humans Interferon-alpha - blood Laboratories Lupus Lupus Erythematosus, Systemic - blood Lupus Erythematosus, Systemic - metabolism Male Middle Aged Patients Prevalence Rheumatology Severity of Illness Index Th1 Cells - immunology Th17 Cells - immunology Th2 Cells - immunology Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - diagnosis Vitamin D Deficiency - metabolism Vitamin deficiency Brazil Rio Grande do Sul Brazil systemic lupus erythematosus cytokine profile Vitamin D 25-hydroxyvitamin D
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Objectives To evaluate the expression of Th1, Th2, and Th17 cytokines in patients with systemic lupus erythematosus (SLE), and verify the association between serum cytokine levels and vitamin D concentration. Methods The sample consisted of 172 patients with SLE. 25-Hydroxyvitamin D (25(OH)D) levels were measured by chemiluminescence and 25(OH)D levels <20 ng/mL were considered to reflect vitamin D deficiency. Serum cytokine levels were measured in once-thawed samples, using a Th1/Th2/Th17 CBA (cytometric beads array) kit. Results One hundred and sixty-one (93.6%) patients were women and 128 (74.4%) were of European descent. Mean patient age was 40.5 ± 13.8 years, and mean age at diagnosis was 31.5 ± 13.4 years. At the time of study entry, patients had a median (IQR) SLEDAI of 2 (1–4) and SLICC of 0 (0–1). Mean 25(OH)D concentration was 25.4 ± 11.04 ng/mL. Fifty-nine (34.3%) patients had a vitamin D deficiency. No statistically significant associations were identified between cytokine and vitamin D levels. The most significant finding was a positive correlation between INF-α levels and SLEDAI (rs = 0.22, p = 0.04). Conclusion Although vitamin D deficiencies are highly prevalent in patients with SLE, vitamin D levels were not significantly associated with patient cytokine profiles. The positive correlation between IFN-α levels and SLEDAI showed in this study corroborates other findings in the literature. The present results did not replicate those of in vitro studies of the effect of vitamin D levels on cytokine profiles. Placebo-controlled intervention trials of the effect of vitamin D on cytokine profiles are still required before any definitive conclusions can be drawn regarding the association between these variables.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0961-2033 1477-0962
DOI:	10.1177/0961203315584811