Search Results - "Hedlund, Gunnar"

Tumor-targeted superantigens produce curative tumor immunity with induction of memory and demonstrated antigen spreading by Azulay, Meir, Shahar, Michal, Shany, Eitan, Elbaz, Eti, Lifshits, Sveta, Törngren, Marie, Friedmann, Adam, Kramer, Robert, Hedlund, Gunnar

“…Despite remarkable progress, the immunotherapies currently used in the clinic, such as immune checkpoint blockade (ICB) therapy, still have limited efficacy…”
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Phase I Dose Escalation, Pharmacokinetic and Pharmacodynamic Study of Naptumomab Estafenatox Alone in Patients With Advanced Cancer and With Docetaxel in Patients With Advanced Non–Small-Cell Lung Cancer by Borghaei, Hossein, Alpaugh, Katherine, Hedlund, Gunnar, Forsberg, Göran, Langer, Corey, Rogatko, Andre, Hawkins, Robert, Dueland, Svein, Lassen, Ulrik, Cohen, Roger B

“…Two phase I studies were conducted of ABR-217620 alone or in combination with docetaxel. This is a recombinant fusion protein consisting of a mutated variant…”
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The tumor targeted superantigen ABR-217620 selectively engages TRBV7-9 and exploits TCR-pMHC affinity mimicry in mediating T cell cytotoxicity by Hedlund, Gunnar, Eriksson, Helena, Sundstedt, Anette, Forsberg, Göran, Jakobsen, Bent K, Pumphrey, Nicholas, Rödström, Karin, Lindkvist-Petersson, Karin, Björk, Per

“…The T lymphocytes are the most important effector cells in immunotherapy of cancer. The conceptual objective for developing the tumor targeted superantigen…”
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Synthesis and Biological Evaluation of New 1,2-Dihydro-4-hydroxy-2-oxo-3-quinolinecarboxamides for Treatment of Autoimmune Disorders:  Structure−Activity Relationship by Jönsson, Stig, Andersson, Gunnar, Fex, Tomas, Fristedt, Tomas, Hedlund, Gunnar, Jansson, Karl, Abramo, Lisbeth, Fritzson, Ingela, Pekarski, Olga, Runström, Anna, Sandin, Helena, Thuvesson, Ingela, Björk, Anders

“…Roquinimex-related 3-quinolinecarboxamide derivatives were prepared and evaluated for treatment of autoimmune disorders. The compounds were tested in mice for…”
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The new orally active immunoregulator laquinimod (ABR-215062) effectively inhibits development and relapses of experimental autoimmune encephalomyelitis by Brunmark, Charlott, Runström, Anna, Ohlsson, Lennart, Sparre, Birgitta, Brodin, Thomas, Åström, Mikael, Hedlund, Gunnar

“…A new orally active drug, laquinimod (ABR-215062), was shown to completely inhibit the development of murine acute experimental autoimmune encephalomyelitis…”
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A model of knowledge management and the N-form corporation by Hedlund, Gunnar

“…A model of knowledge management is developed. It builds on the interplay between articulated and tacit knowledge at four different levels: the individual, the…”
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Abstract 2712: Naptumomab Estafenatox induces T cell recognition, turning anti-PD-1 unresponsive "cold" tumors into "hot" responsive tumors by Azulay, Meir, Lifshits, Sveta, Fridman, Adam, Hedlund, Gunnar, Törngren, Marie, Shahar, Michal

“…Abstract Tumor recognition is a key factor in checkpoint inhibitors (CPI) efficacy and acquired resistance. Lack or loss of tumor antigens expression or…”
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Effects of Linomide on immune cells and cytokines inhibit autoimmune pathologies of the central and peripheral nervous system by Hedlund, Gunnar, Link, Hans, Zhu, Jie, Xiao, Bao-Guo

“…Linomide (roquinimex, LS 2616) is a quinoline-3-carboxamide with pleiotropic immune modulating capacity and it has therapeutic effects in several experimental…”
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Linomide abolishes leukocyte adhesion and extravascular recruitment induced by tumor necrosis factor α in vivo by Zhang, X W, Hedlund, G, Borgström, P, Arfors, K E, Thorlacius, H

“…The immunomodulator Linomide (roquinimex) ameliorates the development of numerous inflammatory and immunological diseases, including sepsis, arthritis, and…”
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T Cell Activation Pathways: B7, LFA-3, and ICAM-1 Shape Unique T Cell Profiles by Wingren, Anette Gjorloff, Parra, Eduardo, Varga, Mikael, Kalland, Terje, Sjogren, Hans-Olov, Hedlund, Gunnar, Dohlsten, Mikael

“…Two signals are required for induction of cell proliferation and cytokine production in resting T cells. Occupancy of the T cell receptor by antigen/MHC…”
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A Randomized Phase II/III Study of Naptumomab Estafenatox + IFNα versus IFNα in Renal Cell Carcinoma: Final Analysis with Baseline Biomarker Subgroup and Trend Analysis by Hawkins, Robert E, Gore, Martin, Shparyk, Yaroslav, Bondar, Vladimir, Gladkov, Oleg, Ganev, Tosho, Harza, Mihai, Polenkov, Serhii, Bondarenko, Igor, Karlov, Petr, Karyakin, Oleg, Khasanov, Rustem, Hedlund, Gunnar, Forsberg, Goran, Nordle, Örjan, Eisen, Timothy

“…To prospectively determine the efficacy of naptumomab estafenatox (Nap) + IFNα versus IFN in metastatic renal cell carcinoma (RCC). In a randomized,…”
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Combining tumor-targeted superantigens with interferon-alpha results in synergistic anti-tumor effects by Sundstedt, Anette, Celander, Mona, Hedlund, Gunnar

“…In this study we explored the possibility of improving the anti-tumor potency of tumor-targeted superantigens (TTS) by combination treatment with…”
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Immunological response and overall survival in a subset of advanced renal cell carcinoma patients from a randomized phase 2/3 study of naptumomab estafenatox plus IFN-α versus IFN-α by Elkord, Eyad, Burt, Deborah J, Sundstedt, Anette, Nordle, Örjan, Hedlund, Gunnar, Hawkins, Robert E

“…Naptumomab estafenatox/ABR-217620/ANYARA (Nap) has been evaluated in clinical phase 1 and 2/3 studies. RCC patients in the phase 2/3 trial were randomized 1:1…”
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Naptumomab Estafenatox: Targeted Immunotherapy with a Novel Immunotoxin by Eisen, Tim, Hedlund, Gunnar, Forsberg, Göran, Hawkins, Robert

“…Improvement of cancer therapy by introducing new concepts is still urgent even though there have been major advancements lately. Immunotherapy is well on the…”
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Laquinimod (ABR-215062) suppresses the development of experimental autoimmune encephalomyelitis, modulates the Th1/Th2 balance and induces the Th3 cytokine TGF-β in Lewis rats by Yang, Jian-She, Xu, Ling-Yun, Xiao, Bao-Guo, Hedlund, Gunnar, Link, Hans

“…The new orally active drug laquinimod (ABR-215062) was evaluated in experimental autoimmune encephalomyelitis (EAE) in the Lewis rat. EAE shares important…”
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Abstract B17: Immunomodulation by tasquinimod: Combination with immunotherapy results in enhanced CD8 T cell responses and improved antitumor effects by Sundstedt, Anette, Olsson, Anders, Stenström, Martin, Celander, Mona, Törngren, Marie, Eriksson, Helena, Hedlund, Gunnar, Liberg, David, Leanderson, Tomas

“…Abstract Purpose: The novel anti-tumor agent tasquinimod (ABR-215050) is being developed for treatment of metastatic castration-resistant prostate cancer…”
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A randomized phase II/III study of naptumomab estafenatox plus IFN-α versus IFN-α in advanced renal cell carcinoma by Hawkins, Robert E., Gore, Martin Eric, Shparyk, Yaroslav, Bondar, Vladimir, Gladkov, Oleg, Ganev, Tosho, Harza, Mihai, Polenkov, Serhii, Bondarenko, Igor, Karlov, Petr A, Karyakin, Oleg, Khasanov, Rustem, Hedlund, Gunnar Eric, Forsberg, Goran, Nordle, Orjan, Eisen, Tim

“…Abstract only 3073 Background: Naptumomab estafenatox/ANYARA (Nap) is a fusion protein of an antibody (5T4) and a superantigen (SEA/E-120). After phase I…”
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Monotherapeutically Nonactive CTLA-4 Blockade Results in Greatly Enhanced Antitumor Effects When Combined With Tumor-targeted Superantigens in a B16 Melanoma Model by SUNDSTEDT, Anette, CELANDER, Mona, ERIKSSON, Helena, TÖRNGREN, Marie, HEDLUND, Gunnar

“…Immunotherapy aiming to block immune suppression with anti-cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) monoclonal antibodies is a recently clinically…”
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A novel co-stimulatory T cell antigen co-expressed on renal cell carcinoma by Labuda, T, Lando, P, Björkdahl, O, Kalland, T, Vessella, R, Hedlund, G, Eriksson, H, Sjögren, H O, Dohlsten, M

“…The A6H mAb raised primarily against human renal cell carcinoma (RCC) has previously been shown to bind strongly to RCC, to some degree to colon carcinoma but…”
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Dendritic cells and macrophages are the first and major producers of TNF-alpha in pancreatic islets in the nonobese diabetic mouse by Dahlén, E, Dawe, K, Ohlsson, L, Hedlund, G

“…The nonobese diabetic (NOD) mouse spontaneously develops autoimmune insulin-dependent diabetes mellitus (IDDM) and serves as an animal model for human type I…”
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