Search Results - "Hedley, Benjamin D"

Myelodysplastic Neoplasms (MDS) with Ring Sideroblasts or SF3B1 Mutations: The Improved Clinical Utility of World Health Organization and International Consensus Classification 2022 Definitions, a Single-Centre Retrospective Chart Review by Mortuza, Shamim, Chin-Yee, Benjamin, James, Tyler E, Chin-Yee, Ian H, Hedley, Benjamin D, Ho, Jenny M, Saini, Lalit, Lazo-Langner, Alejandro, Schenkel, Laila, Bhai, Pratibha, Sadikovic, Bekim, Keow, Jonathan, Sangle, Nikhil, Hsia, Cyrus C

“…Myelodysplastic neoplasms (MDS) with ring sideroblasts (RS) are diagnosed via bone marrow aspiration in the presence of either (i) ≥15% RS or (ii) 5-14% RS and…”
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Epitope-specific antibody responses differentiate COVID-19 outcomes and variants of concern by Voss, Courtney, Esmail, Sally, Liu, Xuguang, Knauer, Michael J, Ackloo, Suzanne, Kaneko, Tomonori, Lowes, Lori, Stogios, Peter, Seitova, Almagul, Hutchinson, Ashley, Yusifov, Farhad, Skarina, Tatiana, Evdokimova, Elena, Loppnau, Peter, Ghiabi, Pegah, Haijan, Taraneh, Zhong, Shanshan, Abdoh, Husam, Hedley, Benjamin D, Bhayana, Vipin, Martin, Claudio M, Slessarev, Marat, Chin-Yee, Benjamin, Fraser, Douglas D, Chin-Yee, Ian, Li, Shawn Sc

“…BACKGROUNDThe role of humoral immunity in COVID-19 is not fully understood, owing, in large part, to the complexity of antibodies produced in response to the…”
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Rapid and accurate agglutination-based testing for SARS-CoV-2 antibodies by Esmail, Sally, Knauer, Michael J., Abdoh, Husam, Voss, Courtney, Chin-Yee, Benjamin, Stogios, Peter, Seitova, Almagul, Hutchinson, Ashley, Yusifov, Farhad, Skarina, Tatiana, Evdokimova, Elena, Ackloo, Suzanne, Lowes, Lori, Hedley, Benjamin D., Bhayana, Vipin, Chin-Yee, Ian, Li, Shawn S.-C.

“…We have developed a rapid, accurate, and cost-effective serologic test for SARS-CoV-2 virus, which caused the COVID-19 pandemic, on the basis of…”
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The thrombin inhibitor Argatroban reduces breast cancer malignancy and metastasis via osteopontin-dependent and osteopontin-independent mechanisms by Schulze, Erika B., Hedley, Benjamin D., Goodale, David, Postenka, Carl O., Al-Katib, Waleed, Tuck, Alan B., Chambers, Ann F., Allan, Alison L.

“…Osteopontin (OPN) has been clinically and experimentally associated with breast cancer metastasis. Proteolytic cleavage of OPN by thrombin has been reported to…”
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The Role of Erythropoietin and Erythropoiesis-Stimulating Agents in Tumor Progression by HEDLEY, Benjamin D, ALLAN, Alison L, XENOCOSTAS, Anargyros

“…Over the past few decades, understanding of the physiologic function of erythropoietin (EPO) has evolved significantly. EPO binds to erythropoietin receptors…”
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synthetic triterpenoid CDDO-Imidazolide suppresses experimental liver metastasis by Townson, Jason L, MacDonald, Ian C, Liby, Karen T, Mackenzie, Lisa, Dales, David W, Hedley, Benjamin D, Foster, Paula J, Sporn, Michael B, Chambers, Ann F

“…Survival following diagnosis of liver metastasis remains poor and improved treatment strategies to combat liver metastases are needed. Synthetic triterpenoids,…”
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High aldehyde dehydrogenase and expression of cancer stem cell markers selects for breast cancer cells with enhanced malignant and metastatic ability by Croker, Alysha K., Goodale, David, Chu, Jenny, Postenka, Carl, Hedley, Benjamin D., Hess, David A., Allan, Alison L.

“…Cancer stem cells (CSCs) have recently been identified in leukaemia and solid tumours; however, the role of CSCs in metastasis remains poorly understood. This…”
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Interim analysis of the clinical performance of five SARS-Cov-2 serology assays by Knauer, Michael J., Hedley, Benjamin D., Bhayana, Vipin, Payne, Michael, Chin-Yee, Ian, Delport, Johan

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Novel lymphocyte screening tube using dried monoclonal antibody reagents by Hedley, Benjamin D., Keeney, Michael, Popma, Janice, Chin‐Yee, Ian

“…We previously developed a 10‐color 11‐antibody combination including a viability dye, to screen T‐, B‐, and natural killer (NK)‐cell populations in blood, bone…”
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Evaluation of Versalyse as an alternative red blood cell lysing agent in the evaluation of CD34 stem and progenitor cells with the ISHAGE guidelines by Lowes, Lori E., Hedley, Benjamin D., Sutherland, D. Robert, Keeney, Michael

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Measurable Residual Disease Detection in B-Acute Lymphoblastic Leukemia: The Children's Oncology Group (COG) Method by Borowitz, Michael J, Wood, Brent L, Keeney, Michael, Hedley, Benjamin D

“…Measurable (minimal) residual disease (MRD) in B-acute lymphoblastic leukemia (B-ALL), as assessed by flow cytometry, is an established prognostic factor used…”
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Implementation of flow cytometry testing on rare matrix samples: Special considerations and best practices when the sample is unique or difficult to obtain by Devitt, Katherine A, Kern, Wolfgang, Kajstura, Malgorzata A, Holl, Eda K, Hays, Amanda L, Hedley, Benjamin D, Gonneau, Christèle, Jellison, Evan R, McCloskey, Thomas W, Mishra, Shruti, Rebeles, Jennifer, Ouseph, Madhu M

“…The publication of Clinical and Laboratory Standards Institute's guideline H62 has provided the flow cytometry community with much-needed guidance on…”
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T‐cell clonality testing for the diagnosis of T‐cell large granular lymphocytic leukemia: Are we identifying pathology or incidental clones? by Chin‐Yee, Benjamin, Suthakaran, Abitha, Hedley, Benjamin D., Howlett, Christopher, Stuart, Alan, Sadikovic, Bekim, Chin‐Yee, Ian H., Hsia, Cyrus C.

“…Introduction T‐cell clonality testing by T‐cell receptor (TCR) gene rearrangement is key to the diagnosis of T‐cell lymphoproliferative disorders such as…”
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Tumor dormancy and the role of metastasis suppressor genes in regulating ectopic growth by Hedley, Benjamin D, Allan, Alison L, Chambers, Ann F

“…Metastasis, or tumor growth in an ectopic site, may occur several years after apparently successful treatment of the primary malignancy. Clinical dormancy is…”
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Clinical Utility of Implementing a Frontline NGS-Based DNA and RNA Fusion Panel Test for Patients with Suspected Myeloid Malignancies by Bhai, Pratibha, Hsia, Cyrus C., Schenkel, Laila C., Hedley, Benjamin D., Levy, Michael A., Kerkhof, Jennifer, Santos, Stephanie, Stuart, Alan, Lin, Hanxin, Broadbent, Robert, Nan, Shirley, Yang, Ping, Xenocostas, Anargyros, Chin-Yee, Ian, Sadikovic, Bekim

“…Background The use of molecular genetic biomarkers is rapidly advancing to aid diagnosis, prognosis, and clinical management of hematological disorders. We…”
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Thrombolysis in the recovery of coagulated bone marrow aspirate samples by Beca, Bogdan Mihai, Radford, Michael James, Hedley, Benjamin D., Chin‐Yee, Ian H., Lazo‐Langner, Alejandro, Hsia, Cyrus C.

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A QA Program for MRD Testing Demonstrates That Systematic Education Can Reduce Discordance Among Experienced Interpreters by Keeney, Michael, Wood, Brent L., Hedley, Benjamin D., DiGiuseppe, Joseph A., Stetler‐Stevenson, Maryalice, Paietta, Elisabeth, Lozanski, Gerard, Seegmiller, Adam C., Greig, Bruce W., Shaver, Aaron C., Mukundan, Lata, Higley, Howard R., Sigman, Caroline C., Kelloff, Gary, Jessup, J. Milburn, Borowitz, Michael J.

“…Background Minimal residual disease (MRD) in B lymphoblastic leukemia (B‐ALL) by flow cytometry is an established prognostic factor used to adjust treatment in…”
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Reducing cytogenetic testing in the era of next generation sequencing: Are we choosing wisely? by Kawata, Eri, Hedley, Benjamin D., Chin‐Yee, Benjamin, Xenocostas, Anargyros, Lazo‐Langner, Alejandro, Hsia, Cyrus C., Howson‐Jan, Kang, Yang, Ping, Levy, Michael A., Santos, Stephanie, Bhai, Pratibha, Howlett, Christopher, Lin, Hanxin, Kadour, Mike, Sadikovic, Bekim, Chin‐Yee, Ian

“…Introduction In most laboratories, next generation sequencing (NGS) has been added without consideration for redundancy compared to conventional cytogenetics…”
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A multicenter study evaluation of the ClearLLab 10C panels by Hedley, Benjamin D., Cheng, Guoyan, Keeney, Michael, Kern, Wolfgang, Padurean, Adrian, Luider, Joanne, Chin‐Yee, Ian, Lowes, Lori E., Rohrbach, Justin, Ortega, Robert, Smit, Astrid, Lo, Ka‐Wai, Magari, Robert, Tejidor, Liliana

“…Multiparameter flow cytometry plays an important role in the diagnosis, staging, and monitoring of patients with a suspected hematological malignancy. The…”
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User‐defined protein marker assay development for characterization of circulating tumor cells using the CellSearch® system by Lowes, Lori E., Hedley, Benjamin D., Keeney, Mike, Allan, Alison L.

“…The majority of cancer‐related deaths result from metastasis, which has been associated with the presence of circulating tumor cells (CTCs). It has been shown…”
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