Search Results - "Hedger, M P"

Activins, follistatin and immunoregulation in the epididymis by Wijayarathna, R., Hedger, M. P.

“…Background The interface between the epididymis and the immune system is implicated in many male reproductive pathologies. The resident immune cell populations…”
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Follistatin is essential for normal postnatal development and function of mouse oviduct and uterus by Holdsworth-Carson, S J, Craythorn, R G, Winnall, W R, Dhaliwal, K, Genovese, R, Nowell, C J, Rogers, P A W, de Kretser, D M, Hedger, M P, Girling, J E

“…Female mice lacking the follistatin gene but expressing a human follistatin-315 transgene (tghFST315) have reproductive abnormalities (reduced follicles, no…”
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Inhibins, activins and follistatin in reproduction by de Kretser, D. M., Hedger, M. P., Loveland, K. L., Phillips, D. J.

“…The regulation of reproductive processes involves a complex network of communication systems between the brain, endocrine organs, the gonads and other…”
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The activins and their binding protein, follistatin—Diagnostic and therapeutic targets in inflammatory disease and fibrosis by Hedger, M.P, de Kretser, D.M

“…Abstract The activins, as members of the transforming growth factor-β superfamily, are pleiotrophic regulators of cell development and function, including…”
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An RNA spiking method demonstrates that 18S rRNA is regulated by progesterone in the mouse uterus by Craythorn, R.G., Girling, J.E., Hedger, M.P., Rogers, P.A.W., Winnall, W.R.

“…Identifying suitable housekeeping genes for quantitative RT–PCR in the uterus is problematic, as this tissue undergoes significant structural and functional…”
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Regulated production of activin A and inhibin B throughout the cycle of the seminiferous epithelium in the rat by Okuma, Y, O’Connor, A E, Hayashi, T, Loveland, K L, de Kretser, D M, Hedger, M P

“…Production and regulation of activin A and inhibin B during the cycle of the seminiferous epithelium were investigated in adult rats. Immunohistochemistry…”
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Reciprocal regulation of activin A and inhibin B by interleukin-1 (IL-1) and follicle-stimulating hormone (FSH) in rat Sertoli cells in vitro by Okuma, Y, Saito, K, O’Connor, A E, Phillips, D J, de Kretser, D M, Hedger, M P

“…In several biological systems, the inhibin βA homodimer activin A is stimulated by, and in turn, inhibits the action of interleukin (IL)-1 (both IL-1α and…”
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Regulation of activin A and inhibin B secretion by inflammatory mediators in adult rat Sertoli cell cultures by Okuma, Y, O’Connor, A E, Muir, J A, Stanton, P G, de Kretser, D M, Hedger, M P

“…The regulation of Sertoli cell activin A and inhibin B secretion during inflammation was investigated in vitro. Adult rat Sertoli cells were incubated with the…”
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Immunophysiology and Pathology of Inflammation in the Testis and Epididymis by Hedger, Mark P.

“…The ability of spermatogenic cells to evade the host immune system and the ability of systemic inflammation to inhibit male reproductive function represent two…”
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Testicular immune cell populations and macrophage polarisation in adult male mice and the influence of altered activin A levels by Indumathy, S., Pueschl, D., Klein, B., Fietz, D., Bergmann, M., Schuppe, H.-C., Da Silva, N., Loveland, B.E., Hickey, M.J., Hedger, M.P., Loveland, K.L.

“…•Adult testicular leukocytes characterized via flow cytometry and confocal microscopy.•Mononuclear phagocyte and lymphocyte heterogeneity documented.•New…”
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The role of activin, follistatin and inhibin in testicular physiology by de Kretser, D.M., Buzzard, J.J., Okuma, Y., O’Connor, A.E., Hayashi, T., Lin, Shyr-Yeu, Morrison, J.R., Loveland, K.L., Hedger, M.P.

“…The role of the inhibins, activins and follistatins in testicular function are being more clearly defined following studies describing the cellular…”
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Expression of monocyte chemoattractant protein-1 and macrophage colony-stimulating factor in normal and inflamed rat testis by Gerdprasert, O., O'Bryan, M.K., Nikolic-Paterson, D.J., Sebire, K., de Kretser, D.M., Hedger, M.P.

“…Macrophages are numerous in the testicular interstitial tissue under normal conditions and increase during inflammation. The mechanisms involved are poorly…”
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Differential effects of dexamethasone treatment on lipopolysaccharide-induced testicular inflammation and reproductive hormone inhibition in adult rats by Gow, RM, O'Bryan, MK, Canny, BJ, Ooi, GT, Hedger, MP

“…A single intraperitoneal injection of lipopolysaccharide (LPS) causes a biphasic suppression of testicular steroidogenesis in adult rats, with inhibition at 6…”
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Local regulation of T cell numbers and lymphocyte-inhibiting activity in the interstitial tissue of the adult rat testis by Hedger, M.P, Meinhardt, A

“…The testis is an immunologically privileged site, and transplantation data suggest that this privilege may be enhanced in cryptorchidism. Although αβT cells,…”
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Activin A and follistatin: their role in the acute phase reaction and inflammation by de Kretser, DM, Hedger, MP, Phillips, DJ

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Leukocyte populations of the adult rat testis following removal of the Leydig cells by treatment with ethane dimethane sulfonate and subcutaneous testosterone implants by Wang, J, Wreford, N G, Lan, H Y, Atkins, R, Hedger, M P

“…The influence of the Leydig cells on the leukocyte population of the testis was investigated. Leydig cells were destroyed by ethane dimethane sulfonate (EDS)…”
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Characterization of lymphocytes in the adult rat testis by flow cytometry: effects of activin and transforming growth factor beta on lymphocyte subsets in vitro by TOMPKINS, A. B, HUTCHINSON, P, DE KRETSER, D. M, HEDGER, M. P

“…The rat testis is considered to be an immunologically privileged site because of its reduced capacity to support antigen-specific immune responses. To…”
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Relationships among body composition, circulating concentrations of leptin and follistatin, and the onset of puberty and fertility in young female sheep by Rosales Nieto, C.A., Thompson, A.N., Macleay, C.A., Briegel, J.R., Hedger, M.P., Ferguson, M.B., Martin, G.B.

“…•Accelerating the accumulation of muscle and adipose tissues can advance puberty.•Accelerating the accumulation of muscle and adipose tissues improved…”
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An in vitro model demonstrates the potential of neoplastic human germ cells to influence the tumour microenvironment by Klein, B., Schuppe, H.‐C., Bergmann, M., Hedger, M. P., Loveland, B. E., Loveland, K. L.

“…Summary Testicular germ cell tumours (TGCT) typically contain high numbers of infiltrating immune cells, yet the functional nature and consequences of…”
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Activin A target genes are differentially expressed between normal and neoplastic adult human testes: clues to gonocyte fate choice by Szarek, M., Bergmann, M., Konrad, L., Schuppe, H.‐C., Kliesch, S., Hedger, M. P., Loveland, K. L.

“…Background Human testicular germ cell tumours (TGCT) arise from germ cell neoplasia in situ (GCNIS) cells that originate from foetal germ cell precursors…”
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