Search Results - "Hedge, Joan M"

Neurotoxicological and thyroid evaluations of rats developmentally exposed to tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) and tris(2-chloro-2-ethyl)phosphate (TCEP) by Moser, Virginia C, Phillips, Pamela M, Hedge, Joan M, McDaniel, Katherine L

“…Abstract Tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) and tris(2-chloro-2-ethyl)phosphate (TCEP) are organophosphorous flame retardants with widespread usage…”
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Short-term Exposure to Triclosan Decreases Thyroxine In Vivo via Upregulation of Hepatic Catabolism in Young Long-Evans Rats by Paul, Katie B., Hedge, Joan M., DeVito, Michael J., Crofton, Kevin M.

“…Triclosan (5-chloro-2-(2,4-dichlorophenoxy)-phenol) is a chlorinated phenolic antibacterial compound found in consumer products. In vitro human pregnane X…”
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Developmental triclosan exposure decreases maternal and neonatal thyroxine in rats by Paul, Katie B., Hedge, Joan M., DeVito, Michael J., Crofton, Kevin M.

“…Disruption of maternal thyroid hormones during fetal developmental may result in irreversible neurological consequences in offspring. The present study tested…”
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Short-term in vivo exposure to the water contaminant triclosan: Evidence for disruption of thyroxine by Crofton, Kevin M, Paul, Katie B, DeVito, Michael J, Hedge, Joan M

“…Abstract Triclosan (5-chloro-2-(2,4-dichlorophenoxy)phenol) is a chlorinated phenolic antibacterial compound found as an active ingredient in many personal…”
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Effect of PCB 126 on Hepatic Metabolism of Thyroxine and Perturbations in the Hypothalamic-Pituitary-Thyroid Axis in the Rat by Fisher, Jeffrey W., Campbell, Jerry, Muralidhara, Srinivasa, Bruckner, James V., Ferguson, Duncan, Mumtaz, Moiz, Harmon, Barry, Hedge, Joan M., Crofton, Kevin M., Kim, Hekap, Almekinder, Tara L.

“…The objective of this research was to examine the time- and dose- dependent disturbances in the hypothalamic-pituitary-thyroid (HPT) axis of adult male rats…”
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Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries by Paul Friedman, Katie, Watt, Eric D, Hornung, Michael W, Hedge, Joan M, Judson, Richard S, Crofton, Kevin M, Houck, Keith A, Simmons, Steven O

“…High-throughput screening for potential thyroid-disrupting chemicals requires a system of assays to capture multiple molecular-initiating events (MIEs) that…”
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Development of a Thyroperoxidase Inhibition Assay for High-Throughput Screening by Paul, Katie B, Hedge, Joan M, Rotroff, Daniel M, Hornung, Michael W, Crofton, Kevin M, Simmons, Steven O

“…High-throughput screening (HTPS) assays to detect inhibitors of thyroperoxidase (TPO), the enzymatic catalyst for thyroid hormone (TH) synthesis, are not…”
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Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: A dynamic and kinetic evaluation of a putative mode-of-action by Paul, Katie B, Hedge, Joan M, Bansal, Ruby, Zoeller, R. Thomas, Peter, Robert, DeVito, Michael J, Crofton, Kevin M

“…Abstract This work tests the mode-of-action (MOA) hypothesis that maternal and developmental triclosan (TCS) exposure decreases circulating thyroxine (T4)…”
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Inconsistencies in variable reporting and methods in larval zebrafish behavioral assays by Hill, Bridgett N., Britton, Katy N., Hunter, Deborah L., Olin, Jeanene K., Lowery, Morgan, Hedge, Joan M., Knapp, Bridget R., Jarema, Kimberly A., Rowson, Zachary, Padilla, Stephanie

“…New approaches in developmental neurotoxicity (DNT) screening are needed due to the tens of thousands of chemicals requiring hazard assessments. Zebrafish…”
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Influence of Methylene Blue or Dimethyl Sulfoxide on Larval Zebrafish Development and Behavior by Hedge, Joan M, Hunter, Deborah L, Sanders, Erik, Jarema, Kimberly A, Olin, Jeanene K, Britton, Katy N, Lowery, Morgan, Knapp, Bridget R, Padilla, Stephanie, Hill, Bridgett N

“…The use of larval zebrafish developmental testing and assessment, specifically larval zebrafish locomotor activity, has been recognized as a higher throughput…”
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Cross-species analysis of thyroperoxidase inhibition by xenobiotics demonstrates conservation of response between pig and rat by Paul, Katie B, Hedge, Joan M, Macherla, Chitralekha, Filer, Dayne L, Burgess, Emily, Simmons, Steven O, Crofton, Kevin M, Hornung, Michael W

“…Abstract Thyroperoxidase (TPO), the enzyme that catalyzes the synthesis of thyroid hormone, is a known target for thyroid-disrupting chemicals. In vivo…”
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Assessment of DE-71, a Commercial Polybrominated Diphenyl Ether (PBDE) Mixture, in the EDSP Male and Female Pubertal Protocols by Stoker, Tammy E., Laws, Susan C., Crofton, Kevin M., Hedge, Joan M., Ferrell, Janet M., Cooper, Ralph L.

“…DE-71, a commercial mixture, was used to test the sensitivity of the female and male pubertal protocol to detect thyroid active chemicals. These protocols are…”
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An animal model of marginal iodine deficiency during development: the thyroid axis and neurodevelopmental outcome by Gilbert, Mary E, Hedge, Joan M, Valentín-Blasini, Liza, Blount, Benjamin C, Kannan, Kurunthachalam, Tietge, Joseph, Zoeller, R Thomas, Crofton, Kevin M, Jarrett, Jeffrey M, Fisher, Jeffrey W

“…Thyroid hormones (THs) are essential for brain development, and iodine is required for TH synthesis. Environmental chemicals that perturb the thyroid axis…”
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Thyroid-Hormone-Disrupting Chemicals: Evidence for Dose-Dependent Additivity or Synergism by Crofton, Kevin M., Craft, Elena S., Hedge, Joan M., Gennings, Chris, Simmons, Jane E., Carchman, Richard A., Carter, W. Hans, DeVito, Michael J.

“…Endocrine disruption from environmental contaminants has been linked to a broad spectrum of adverse outcomes. One concern about endocrine-disrupting…”
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Assessment of serum biomarkers in rats after exposure to pesticides of different chemical classes by Moser, Virginia C., Stewart, Nicholas, Freeborn, Danielle L., Crooks, James, MacMillan, Denise K., Hedge, Joan M., Wood, Charles E., McMahen, Rebecca L., Strynar, Mark J., Herr, David W.

“…There is increasing emphasis on the use of biomarkers of adverse outcomes in safety assessment and translational research. We evaluated serum biomarkers and…”
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Low-Dose Effects of Ammonium Perchlorate on the Hypothalamic-Pituitary-Thyroid Axis of Adult Male Rats Pretreated with PCB126 by McLanahan, Eva D., Campbell, Jerry L., Ferguson, Duncan C., Harmon, Barry, Hedge, Joan M., Crofton, Kevin M., Mattie, David R., Braverman, Lewis, Keys, Deborah A., Mumtaz, Moiz, Fisher, Jeffrey W.

“…The objective of this research was to characterize the disturbances in the hypothalamic-pituitary-thyroid (HPT) axis resulting from exposure to a binary…”
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Lack of Alterations in Thyroid Hormones Following Exposure to Polybrominated Diphenyl Ether 47 during a Period of Rapid Brain Development in Mice by Gee, Jillian R., Hedge, Joan M., Moser, Virginia C.

“…Thyroid alterations have been shown to occur following exposure to polybrominated diphenyl ether (PBDE) mixtures, possibly indicating that disruptions in…”
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Influence of the drinking water disinfection by-product dibromoacetic acid on rat estrous cyclicity and ovarian follicular steroid release in vitro by Balchak, Sharon K, Hedge, Joan M, Murr, Ashley S, Leonard Mole, M, Goldman, Jerome M

“…The drinking water disinfection by-product, dibromoacetic acid (DBA) has been reported to affect gonadal functions in the male rat. However, there is little…”
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Dibromoacetic acid does not adversely affect early pregnancy in rats by Cummings, Audrey M, Hedge, Joan M

“…Dibromoacetic acid (DBA), a byproduct of water disinfection, has been shown to have adverse reproductive effects in male rodents. In light of the lack of data…”
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Effect of prenatal exposure to TCDD on the promotion of endometriotic lesion growth by TCDD in adult female rats and mice by CUMMINGS, A. M, HEDGE, J. M, BIRNBAUM, L. S

“…Several lines of research led to our hypothesis that perinatal exposure to TCDD may alter the sensitivity of adult rodents to the promotional effect of…”
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