Search Results - "Hedegaard, A."

Label-free 3D molecular imaging of living tissues using Raman spectral projection tomography by Stepula, Elzbieta, Walther, Anders R., Jensen, Magnus, Mehrotra, Dev R., Yuan, Mu H., Pedersen, Simon V., Kumar, Vishal, Gentleman, Eileen, Albro, Michael B., Hedegaard, Martin A. B., Bergholt, Mads S.

“…The ability to image tissues in three dimensions (3D) with label-free molecular contrast at the mesoscale would be a valuable capability in biology and…”
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Increased Axon Initial Segment Length Results in Increased Na+ Currents in Spinal Motoneurones at Symptom Onset in the G127X SOD1 Mouse Model of Amyotrophic Lateral Sclerosis by Jørgensen, H.S., Jensen, D.B., Dimintiyanova, K.P., Bonnevie, V.S., Hedegaard, A., Lehnhoff, J., Moldovan, M., Grondahl, L., Meehan, C.F.

“…•In vivo electrophysiological recordings were made in symptomatic G127X SOD1 mice.•There were no deficits in repetitive firing in motoneurones in G127X…”
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Shorter axon initial segments do not cause repetitive firing impairments in the adult presymptomatic G127X SOD-1 Amyotrophic Lateral Sclerosis mouse by Bonnevie, V. S., Dimintiyanova, K. P., Hedegaard, A., Lehnhoff, J., Grøndahl, L., Moldovan, M., Meehan, C. F.

“…Increases in axonal sodium currents in peripheral nerves are some of the earliest excitability changes observed in Amyotrophic Lateral Sclerosis (ALS)…”
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Spatially resolved spectroscopic differentiation of hydrophilic and hydrophobic domains on individual insulin amyloid fibrils by Deckert-Gaudig, Tanja, Kurouski, Dmitry, Hedegaard, Martin A. B., Singh, Pushkar, Lednev, Igor K., Deckert, Volker

“…The formation of insoluble β-sheet-rich protein structures known as amyloid fibrils is associated with numerous neurodegenerative diseases, such as Alzheimer’s…”
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Identification and Metabolic Profiling of a Novel Human Gut-derived LEAP2 Fragment by Hagemann, Christoffer A, Zhang, Chen, Hansen, Henrik H, Jorsal, Tina, Rigbolt, Kristoffer T G, Madsen, Martin R, Bergmann, Natasha C, Heimbürger, Sebastian M N, Falkenhahn, Mechthilde, Theis, Stefan, Breitschopf, Kristin, Holm, Stephanie, Hedegaard, Morten A, Christensen, Mikkel B, Vilsbøll, Tina, Holst, Birgitte, Vrang, Niels, Jelsing, Jacob, Knop, Filip K

“…Abstract Context The mechanisms underlying Roux-en-Y gastric bypass (RYGB) surgery-induced weight loss and the immediate postoperative beneficial metabolic…”
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Sparse feature selection methods identify unexpected global cellular response to strontium-containing materials by Autefage, Hélène, Gentleman, Eileen, Littmann, Elena, Hedegaard, Martin A. B., Von Erlach, Thomas, O’Donnell, Matthew, Burden, Frank R., Winkler, David A., Stevens, Molly M.

“…Significance Although new-generation biomaterials are increasingly complex and sophisticated, their development remains largely empirical, and functional…”
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Metabolic insights from a GHSR-A203E mutant mouse model by Torz, Lola J., Osborne-Lawrence, Sherri, Rodriguez, Juan, He, Zhenyan, Cornejo, María Paula, Mustafá, Emilio Román, Jin, Chunyu, Petersen, Natalia, Hedegaard, Morten A., Nybo, Maja, Damonte, Valentina Martínez, Metzger, Nathan P., Mani, Bharath K., Williams, Kevin W., Raingo, Jesica, Perello, Mario, Holst, Birgitte, Zigman, Jeffrey M.

“…Binding of ghrelin to its receptor, growth hormone secretagogue receptor (GHSR), stimulates GH release, induces eating, and increases blood glucose. These…”
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Postactivation depression of the Ia EPSP in motoneurons is reduced in both the G127X SOD1 model of amyotrophic lateral sclerosis and in aged mice by Hedegaard, A, Lehnhoff, J, Moldovan, M, Grøndahl, L, Petersen, N C, Meehan, C F

“…Postactivation depression (PActD) of Ia afferent excitatory postsynaptic potentials (EPSPs) in spinal motoneurons results in a long-lasting depression of the…”
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Model based variable selection as a tool to highlight biological differences in Raman spectra of cells by Hedegaard, Martin A B, Cloyd, Kristy L, Horejs, Christine-Maria, Stevens, Molly M

“…In vitro Raman spectroscopy used for non-invasive, non-destructive characterization of single cells and tissues has proven to be a powerful tool for…”
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Quantitative multi-image analysis for biomedical Raman spectroscopic imaging by Hedegaard, Martin A. B., Bergholt, Mads S., Stevens, Molly M.

“…Imaging by Raman spectroscopy enables unparalleled label‐free insights into cell and tissue composition at the molecular level. With established approaches…”
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High resolution Raman spectroscopy mapping of stem cell micropatterns by von Erlach, Thomas C, Hedegaard, Martin A B, Stevens, Molly M

“…We report on the use of high resolution Raman spectroscopy mapping combined with a micro-engineered stem cell platform. This technique obtains quantitative…”
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Determination of stem cell pluripotency in spent cultivation media by Raman spectroscopy by Hagedorn, Jeppe, Halloin, Caroline, Skibsted, Erik, Poulsen, Lars, Hedegaard, Martin A. B.

“…To achieve successful cultivation of pluripotent stem cells using suspension (3D) culture methods, it is essential to maintain the pluripotent state while…”
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Million Microfiber Releases: Comparing Washable and Disposable Face Masks by Huang, Yuyue, Laghrissi, Ayoub, Fiutowski, Jacek, Hedegaard, Martin A. B., Duan, Xiaoyu, Wang, Xin, Helal, Mohamed, Rubahn, Horst-Günter, Holbech, Henrik, Hardiman, Gary, Xu, Xiangrong, Xu, Elvis Genbo

“…The extensive use of single-use or disposable face masks has raised environmental concerns related to microfiber contamination. In contrast, research on the…”
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Translation Approach for Dentine Regeneration Using GSK-3 Antagonists by Zaugg, L.K., Banu, A., Walther, A.R., Chandrasekaran, D., Babb, R.C., Salzlechner, C., Hedegaard, M.A.B., Gentleman, E., Sharpe, P.T.

“…The canonical Wnt/β-catenin signaling pathway is crucial for reparative dentinogenesis following tooth damage, and the modulation of this pathway affects the…”
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Visualization and characterisation of defined hair follicle compartments by Fourier transform infrared (FTIR) imaging without labelling by Lau, Katherine, Hedegaard, Martin A.B, Kloepper, Jennifer E, Paus, Ralf, Wood, Bayden R, Deckert, Volker

“…Abstract Background To visualise and characterise skin architecture, the tissue usually has to be destroyed and labelled. Objectives The use of Fourier…”
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Spectral Unmixing for Label-Free, In-Liquid Characterization of Biomass Microstructure and Biopolymer Content by Coherent Raman Imaging by Vilms Pedersen, Simon, Brewer, Jonathan R., Hedegaard, Martin A.B., Arnspang Christensen, Eva

“…Characterization of lignocellulosic biomass microstructure with chemical specificity and under physiological conditions could provide invaluable insights to…”
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In Vivo Longitudinal Monitoring of Disease Progression in Inflammatory Arthritis Animal Models Using Raman Spectroscopy by Walther, Anders R., Stepula, Elzbieta, Ditzel, Nicholas, Kassem, Moustapha, Bergholt, Mads S., Hedegaard, Martin A. B.

“…Current techniques for monitoring disease progression and testing drug efficacy in animal models of inflammatory arthritis are either destructive,…”
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Raman spectroscopic evidence of tissue restructuring in heat-induced tissue fusion by Su, Lei, Cloyd, Kristy L., Arya, Shobhit, Hedegaard, Martin A. B., Steele, Joseph A. M., Elson, Daniel S., Stevens, Molly M., Hanna, George B.

“…Heat‐induced tissue fusion via radio‐frequency (RF) energy has gained wide acceptance clinically and here we present the first optical‐Raman‐spectroscopy study…”
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Initial Pharmacological Characterization of a Major Hydroxy Metabolite of PF-5190457: Inverse Agonist Activity of PF-6870961 at the Ghrelin Receptor by Deschaine, Sara L, Hedegaard, Morten A, Pince, Claire L, Farokhnia, Mehdi, Moose, Jacob E, Stock, Ingrid A, Adusumalli, Sravani, Akhlaghi, Fatemeh, Hougland, James L, Sulima, Agnieszka, Rice, Kenner C, Koob, George F, Vendruscolo, Leandro F, Holst, Birgitte, Leggio, Lorenzo

“…Preclinical and clinical studies have identified the ghrelin receptor [growth hormone secretagogue receptor (GHSR)1a] as a potential target for treating…”
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An engineered, quantifiable in vitro model for analysing the effect of proteostasis-targeting drugs on tissue physical properties by Loaiza, Sandra, Ferreira, Silvia A., Chinn, Tamara M., Kirby, Alex, Tsolaki, Elena, Dondi, Camilla, Parzych, Katarzyna, Strange, Adam P., Bozec, Laurent, Bertazzo, Sergio, Hedegaard, Martin A.B., Gentleman, Eileen, Auner, Holger W.

“…Cellular function depends on the maintenance of protein homeostasis (proteostasis) by regulated protein degradation. Chronic dysregulation of proteostasis is…”
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