Search Results - "Heckman, C.J."

Motoneuron excitability: The importance of neuromodulatory inputs by Heckman, C.J, Mottram, Carol, Quinlan, Kathy, Theiss, Renee, Schuster, Jenna

“…Abstract The excitability of spinal motoneurons is both fundamental for motor behavior and essential in diagnosis of neural disorders. There are two mechanisms…”
Get full text

Persistent Inward Currents in Spinal Motoneurons and Their Influence on Human Motoneuron Firing Patterns by Heckman, C.J., Johnson, Michael, Mottram, Carol, Schuster, Jenna

“…Persistent inward currents (PICs) are present in many types of neurons and likely have diverse functions. In spinal motoneurons, PICs are especially strong,…”
Get full text

Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology by Ziller, Michael J., Ortega, Juan A., Quinlan, Katharina A., Santos, David P., Gu, Hongcang, Martin, Eric J., Galonska, Christina, Pop, Ramona, Maidl, Susanne, Di Pardo, Alba, Huang, Mei, Meltzer, Herbert Y., Gnirke, Andreas, Heckman, C.J., Meissner, Alexander, Kiskinis, Evangelos

“…The somatic DNA methylation (DNAme) landscape is established early in development but remains highly dynamic within focal regions that overlap with gene…”
Get full text

Persistent inward currents in spinal motoneurons: Important for normal function but potentially harmful after spinal cord injury and in amyotrophic lateral sclerosis by ElBasiouny, S.M, Schuster, J.E, Heckman, C.J

“…Abstract Meaningful body movements depend on the interplay between synaptic inputs to motoneurons and their intrinsic properties. Injury and disease often…”
Get full text

Motor Unit Discharge Variability Is Increased in Mild-To-Moderate Parkinson's Disease by Wilson, Jessica M, Thompson, Christopher K, McPherson, Laura Miller, Zadikoff, Cindy, Heckman, C J, MacKinnon, Colum D

“…Individuals with Parkinson's disease (PD) demonstrate deficits in muscle activation such as decreased amplitude and inappropriate bursting. There is evidence…”
Get full text

Motor unit by Heckman, C J, Enoka, Roger M

“…Movement is accomplished by the controlled activation of motor unit populations. Our understanding of motor unit physiology has been derived from experimental…”
Get more information

Design and evaluation of a chronic EMG multichannel detection system for long-term recordings of hindlimb muscles in behaving mice by Tysseling, Vicki M, Janes, Lindsay, Imhoff, Rebecca, Quinlan, Katharina A, Lookabaugh, Brad, Ramalingam, Shyma, Heckman, C.J, Tresch, Matthew C

“…Abstract Mouse models are commonly used for identifying the behavioral consequences of genetic modifications, progression or recovery from disease or trauma…”
Get full text

Data for spatial characterization of AC signal propagation over primary neuron dendrites by Kim, Hojeong, Heckman, C.J.

“…Action potentials generated near the soma propagate not only into the axonal nerve connecting to the adjacent neurons but also into the dendrites interacting…”
Get full text

Correspondence of physical activity and fruit/vegetable consumption among prostate cancer survivors and their spouses by Myers Virtue, S., Manne, S.L., Kashy, D., Heckman, C.J., Zaider, T., Kissane, D.W., Kim, I., Lee, D., Olekson, G.

“…A healthy diet and physical activity are recommended for prostate cancer survivors. Interdependence theory suggests that the spousal relationship influences…”
Get full text

Expression of L-type calcium channel α1 -1.2 and α1 -1.3 subunits on rat sacral motoneurons following chronic spinal cord injury by Anelli, R, Sanelli, L, Bennett, D.J, Heckman, C.J

“…Abstract In the presence of the monoamines serotonin and norepinephrine, motoneurons readily generate large persistent inward currents (PICs). The resulting…”
Get full text

Properties of Motor Units of Elbow and Ankle Muscles Decomposed Using High-Density Surface EMG by Hassan, Altamash S., Kim, Edward H., Khurram, Obaid U., Cummings, Mark, Thompson, Christopher K., Miller McPherson, Laura, Heckman, C.J., Dewald, Julius P.A., Negro, Francesco

“…Analyses of motor unit activity provide a window to the neural control of motor output. In recent years, considerable advancements in surface EMG decomposition…”
Get full text

Muscle Spasms after Spinal Cord Injury Stem from Changes in Motoneuron Excitability and Synaptic Inhibition, Not Synaptic Excitation by Mahrous, Amr, Birch, Derin, Heckman, C J, Tysseling, Vicki

“…Muscle spasms are common in chronic spinal cord injury (SCI), posing challenges to rehabilitation and daily activities. Pharmacological management of spasms…”
Get full text

The excitable motor unit: A powerful diagnostic and pathophysiological marker for ALS? by Fajardo, Melissa E., Jenz, Sophia, Heckman, C.J.

Get full text

Slowly activating outward membrane currents generate input-output sub-harmonic cross frequency coupling in neurons by Sinha, Nirvik, Heckman, C.J., Yang, Yuan

“…•We investigated the role of an important ionic conductance mechanism.•Increasing the peak conductance of slow K+ channel yields sub-harmonic…”
Get full text

Foundational dendritic processing that is independent of the cell type-specific structure in model primary neurons by Kim, Hojeong, Heckman, C.J.

“…•Primary neurons in CNS exhibit very distinctive structures of the dendrites.•Dependency of dendritic signalling and excitability and their relationship on…”
Get full text

A single‐arm pilot of a web‐based intervention to improve itch‐related quality of life by Heckman, C.J., Riley, M., Niu, Z., Lu, S.‐E., Valdes‐Rodriguez, R., Yosipovitch, G.

“…Background Many patients with chronic itch and atopic dermatitis (AD) or psoriasis do not receive/use available medical and psychosocial treatments properly…”
Get full text

Simultaneous Intracellular Recording of a Lumbar Motoneuron and the Force Produced by its Motor Unit in the Adult Mouse In vivo by Manuel, Marin, Heckman, C.J.

Get full text

Motoneuron intrinsic properties, but not their receptive fields, recover in chronic spinal injury by Johnson, Michael D, Kajtaz, Elma, Cain, Charlette M, Heckman, C J

“…Proper movement execution relies on precise input processing by spinal motoneurons (MNs). Spinal MNs are activated by limb joint rotations. Typically, their…”
Get full text

Stronger is not always better: Could a bodybuilding dietary supplement lead to ALS? by Manuel, Marin, Heckman, C.J.

Get full text

Hyperexcitable dendrites in motoneurons and their neuromodulatory control during motor behavior by Heckman, C.J., Lee, Robert H., Brownstone, Robert M.

“…Dendrites contain voltage-sensitive conductances that, in vivo, can be influenced by neuromodulatory inputs. In spinal motoneurons, dendrites have…”
Get full text