Search Results - "Heckman, C. J."

Nonlinear Input-Output Functions of Motoneurons by Binder, Marc D, Powers, Randall K, Heckman, C J

“…All movements are generated by the activation of motoneurons, and hence their input-output properties define the final step in processing of all motor…”
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Progressive recruitment of contralesional cortico‐reticulospinal pathways drives motor impairment post stroke by McPherson, Jacob G., Chen, Albert, Ellis, Michael D., Yao, Jun, Heckman, C. J., Dewald, Julius P. A.

“…Key points Activation of the shoulder abductor muscles in the arm opposite a unilateral brain injury causes involuntary increases in elbow, wrist and finger…”
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Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS by Martínez-Silva, María de Lourdes, Imhoff-Manuel, Rebecca D, Sharma, Aarti, Heckman, C J, Shneider, Neil A, Roselli, Francesco, Zytnicki, Daniel, Manuel, Marin

“…Hyperexcitability has been suggested to contribute to motoneuron degeneration in amyotrophic lateral sclerosis (ALS). If this is so, and given that the…”
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Estimates of persistent inward currents are reduced in upper limb motor units of older adults by Hassan, Altamash S., Fajardo, Melissa E., Cummings, Mark, McPherson, Laura Miller, Negro, Francesco, Dewald, Julius P. A., Heckman, C. J., Pearcey, Gregory E. P.

“…Ageing is a natural process causing alterations in the neuromuscular system, which contributes to reduced quality of life. Motor unit (MU) contributes to…”
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Muscle Spasms after Spinal Cord Injury Stem from Changes in Motoneuron Excitability and Synaptic Inhibition, Not Synaptic Excitation by Mahrous, Amr, Birch, Derin, Heckman, C J, Tysseling, Vicki

“…Muscle spasms are common in chronic spinal cord injury (SCI), posing challenges to rehabilitation and daily activities. Pharmacological management of spasms…”
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Estimates of persistent inward currents in tibialis anterior motor units during standing ramped contraction tasks in humans by Khurram, Obaid U, Negro, Francesco, Heckman, C J, Thompson, Christopher K

“…Persistent inward currents (PICs) play an essential role in setting motor neuron gain and shaping motor unit firing patterns. Estimates of PICs in humans can…”
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Motoneuron excitability: The importance of neuromodulatory inputs by Heckman, C.J, Mottram, Carol, Quinlan, Kathy, Theiss, Renee, Schuster, Jenna

“…Abstract The excitability of spinal motoneurons is both fundamental for motor behavior and essential in diagnosis of neural disorders. There are two mechanisms…”
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Impact of parameter selection on estimates of motoneuron excitability using paired motor unit analysis by Hassan, Altamash, Thompson, Christopher K, Negro, Francesco, Cummings, Mark, Powers, Randall K, Heckman, C J, Dewald, Julius P A, McPherson, Laura Miller

“…Noninvasive estimation of motoneuron excitability in human motoneurons is achieved through a paired motor unit analysis (ΔF) that quantifies hysteresis in the…”
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Slowly activating outward membrane currents generate input-output sub-harmonic cross frequency coupling in neurons by Sinha, Nirvik, Heckman, C.J., Yang, Yuan

“…•We investigated the role of an important ionic conductance mechanism.•Increasing the peak conductance of slow K+ channel yields sub-harmonic…”
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The essential and downstream common proteins of amyotrophic lateral sclerosis: A protein-protein interaction network analysis by Mao, Yimin, Kuo, Su-Wei, Chen, Le, Heckman, C J, Jiang, M C

“…Amyotrophic Lateral Sclerosis (ALS) is a devastative neurodegenerative disease characterized by selective loss of motoneurons. While several breakthroughs have…”
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Increased persistent Na+ current and its effect on excitability in motoneurones cultured from mutant SOD1 mice by Kuo, J. J., Siddique, T., Fu, R., Heckman, C. J.

“…Mutations in the enzyme superoxide dismutase 1 (SOD1) initiate a progressive motoneurone degeneration in amyotrophic lateral sclerosis (ALS). Transgenic mice…”
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Asymmetry in signal propagation between the soma and dendrites plays a key role in determining dendritic excitability in motoneurons by Kim, Hojeong, Jones, Kelvin E, Heckman, C J

“…It is widely recognized that propagation of electrophysiological signals between the soma and dendrites of neurons differs depending on direction, i.e. it is…”
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Origins of Abnormal Excitability in Biceps Brachii Motoneurons of Spastic-Paretic Stroke Survivors by Mottram, Carol J, Suresh, Nina L, Heckman, C. J, Gorassini, Monica A, Rymer, William Z

“…1 Sensory Motor Performance Program, Rehabilitation Institute of Chicago; 2 Department of Physiology and Department of Physical Medicine and Rehabilitation,…”
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Persistent inward currents in motoneuron dendrites: Implications for motor output by Heckman, C. J., Gorassini, Monica A., Bennett, David J.

“…The dendrites of motoneurons are not, as once thought, passive conduits for synaptic inputs. Instead they have voltage‐dependent channels that provide the…”
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Altered postnatal maturation of electrical properties in spinal motoneurons in a mouse model of amyotrophic lateral sclerosis by Quinlan, K. A., Schuster, J. E., Fu, R., Siddique, T., Heckman, C. J.

“…Non‐technical summary  Our focus was on whether amyotrophic lateral sclerosis (ALS) might be precipitated by early developmental changes in large spinal…”
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Progressive Changes in Synaptic Inputs to Motoneurons in Adult Sacral Spinal Cord of a Mouse Model of Amyotrophic Lateral Sclerosis by Jiang, Mingchen, Schuster, Jenna E, Fu, Ronggen, Siddique, Teepu, Heckman, C. J

“…Amyotrophic lateral sclerosis (ALS) is characterized by progressive degeneration of motoneurons. One potential mechanism is excitotoxicity. We studied the…”
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Fast Kinetics, High-Frequency Oscillations, and Subprimary Firing Range in Adult Mouse Spinal Motoneurons by Manuel, Marin, Iglesias, Caroline, Donnet, Maud, Leroy, Felix, Heckman, C. J, Zytnicki, Daniel

“…The fast contraction time of mouse motor units creates a unique situation in which motoneurons have to fire at low frequencies to produce small forces but also…”
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Contribution of intrinsic properties and synaptic inputs to motoneuron discharge patterns: a simulation study by Powers, Randall K, Elbasiouny, Sherif M, Rymer, W Zev, Heckman, C J

“…Motoneuron discharge patterns reflect the interaction of synaptic inputs with intrinsic conductances. Recent work has focused on the contribution of…”
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Active properties of motoneurone dendrites: diffuse descending neuromodulation, focused local inhibition by Heckman, C. J., Hyngstrom, Allison S., Johnson, Michael D.

“…The dendrites of spinal motoneurones are highly active, generating a strong persistent inward current (PIC) that has an enormous impact on processing of…”
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Disturbances of motor unit rate modulation are prevalent in muscles of spastic-paretic stroke survivors by Mottram, C J, Heckman, C J, Powers, R K, Rymer, W Z, Suresh, N L

“…Stroke survivors often exhibit abnormally low motor unit firing rates during voluntary muscle activation. Our purpose was to assess the prevalence of…”
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