Search Results - "Heck, Steven D."

Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand by Zhang, Lei, Villalobos, Anabella, Beck, Elizabeth M, Bocan, Thomas, Chappie, Thomas A, Chen, Laigao, Grimwood, Sarah, Heck, Steven D, Helal, Christopher J, Hou, Xinjun, Humphrey, John M, Lu, Jiemin, Skaddan, Marc B, McCarthy, Timothy J, Verhoest, Patrick R, Wager, Travis T, Zasadny, Kenneth

“…To accelerate the discovery of novel small molecule central nervous system (CNS) positron emission tomography (PET) ligands, we aimed to define a property…”
Get full text

Project-Focused Activity and Knowledge Tracker: A Unified Data Analysis, Collaboration, and Workflow Tool for Medicinal Chemistry Project Teams by Brodney, Marian D, Brosius, Arthur D, Gregory, Tracy, Heck, Steven D, Klug-McLeod, Jacquelyn L, Poss, Christopher S

“…Advances in the field of drug discovery have brought an explosion in the quantity of data available to medicinal chemists and other project team members. New…”
Get full text

Biaryl piperidines as potent and selective delta opioid receptor ligands by Liras, Spiros, McHardy, Stanton F., Allen, Martin P., Segelstein, Barb E., Heck, Steven D., Bryce, Dianne K., Schmidt, Anne W., Vanase-Frawley, Michelle, Callegari, Ernesto, McLean, Stafford

“…The design and synthesis of novel opiates are reported. Based on the message-address principle a novel class of 4,4- and 3,3-biaryl piperidines was designed…”
Get full text

Disulfide Bond Assignment of .omega.-Agatoxins IVB and IVC: Discovery of a D-Serine Residue in .omega.-Agatoxin IVB by Heck, Steven D, Kelbaugh, Paul R, Kelly, Mary E, Thadeio, Peter F, Saccomano, Nicholas A, Stroh, Justin G, Volkmann, Robert A

“…A TCEP (tris(2-carboxyethyl)phosphine)-based reduction/cysteine amidoalkylation strategy was utilized to solve the disulfide structures of omega -agatoxins IVB…”
Get full text

Substituted 6-phenyl-pyridin-2-ylamines: selective and potent inhibitors of neuronal nitric oxide synthase by Nason, Deane M, Heck, Steven D, Bodenstein, Mathew S, Lowe, John A, Nelson, Robert B, Liston, Dane R, Nolan, Charles E, Lanyon, Lorraine F, Ward, Karen M, Volkmann, Robert A

“…The synthesis and nNOS/eNOS activity of 6-(4-(dimethylaminoalkyl)/-(4-(dimethylaminoalkoxy)-5-ethyl-2-methoxyphenyl)-pyridin-2-ylamines and…”
Get full text

Posttranslational Amino Acid Epimerization: Enzyme-Catalyzed Isomerization of Amino Acid Residues in Peptide Chains by Heck, Steven D., Faraci, W. Stephen, Kelbaugh, Paul R., Saccomano, Nicholas A., Thadeio, Peter F., Volkmann, Robert A.

“…Since ribosomally mediated protein biosynthesis is confined to the L-amino acid pool, the presence of D-amino acids in peptides was considered for many years…”
Get full text

Inhibition of neuronal calcium channels by a novel peptide spider toxin, DW13.3 by Sutton, K G, Siok, C, Stea, A, Zamponi, G W, Heck, S D, Volkmann, R A, Ahlijanian, M K, Snutch, T P

“…Peptide toxins have proved to be useful agents, both in discriminating between different components of native calcium channel currents and in the molecular…”
Get more information

Functional Consequences of Posttranslation Isomerization of Ser$^{46}$ in a Calcium Channel Toxin by Heck, Steven D., Siok, Chester J., Krapcho, Karen J., Kelbaugh, Paul R., Thadeio, Peter F., Welch, Melissa J., Williams, Robert D., Ganong, Alan H., Kelly, Mary E., Lanzetti, Anthony J., Gray, William R., Phillips, Douglas, Parks, Thomas N., Jackson, Hunter, Ahlijanian, Michael K., Saccomano, Nicholas A., Volkmann, Robert A.

“…The venom of the funnel-web spider Agelenopsis aperta contains several peptides that paralyze prey by blocking voltage-sensitive calcium channels. Two…”
Get full text

Functional Consequences of Posttranslational Isomerization of Ser 46 in a Calcium Channel Toxin by Heck, Steven D., Siok, Chester J., Krapcho, Karen J., Kelbaugh, Paul R., Thadeio, Peter F., Welch, Melissa J., Williams, Robert D., Ganong, Alan H., Kelly, Mary E., Lanzetti, Anthony J., Gray, William R., Phillips, Douglas, Parks, Thomas N., Jackson, Hunter, Ahlijanian, Michael K., Saccomano, Nicholas A., Volkmann, Robert A.

“…The venom of the funnel-web spider Agelenopsis aperta contains several peptides that paralyze prey by blocking voltage-sensitive calcium channels. Two…”
Get full text

Functional consequences of posttranslational isomerization of Ser46 in a calcium channel toxin by HECK, S. D, SIOK, C. J, GRAY, W. R, PHILLIPS, D, PARKS, T. N, JACKSON, H, AHLIJANIAN, M. K, SACCOMANO, N. A, VOLKMANN, R. A, KRAPCHO, K. J, KELBAUGH, P. R, THADEIO, P. F, WELCH, M. J, WILLIAMS, R. D, GANONG, A. H, KELLY, M. E, LANZETTI, A. J

“…The venom of the funnel-web spider Agelenopsis aperta contains several peptides that paralyze prey by blocking voltage-sensitive calcium channels. Two…”
Get full text