Search Results - "Heck, Diane E."

Mechanisms of oxidant generation by catalase by Heck, Diane E., Shakarjian, Michael, Kim, Hong Duck, Laskin, Jeffrey D., Vetrano, Anna M.

“…The enzyme catalase converts solar radiation into reactive oxidant species (ROS). In this study, we report that several bacterial catalases (hydroperoxidases,…”
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Application of the Amplex red/horseradish peroxidase assay to measure hydrogen peroxide generation by recombinant microsomal enzymes by Mishin, Vladimir, Gray, Joshua P., Heck, Diane E., Laskin, Debra L., Laskin, Jeffrey D.

“…The formation of reactive oxygen species by the cytochrome P450 monooxygenase system is thought to be due to autoxidation of NADPH-cytochrome P450 reductase…”
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Mechanisms Mediating the Vesicant Actions of Sulfur Mustard after Cutaneous Exposure by Shakarjian, Michael P., Heck, Diane E., Gray, Joshua P., Sinko, Patrick J., Gordon, Marion K., Casillas, Robert P., Heindel, Ned D., Gerecke, Donald R., Laskin, Debra L., Laskin, Jeffrey D.

“…Sulfur mustard (SM), a chemical weapon first employed during World War I, targets the skin, eyes, and lung. It remains a significant military and civilian…”
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Differential metabolism of 4-hydroxynonenal in liver, lung and brain of mice and rats by Zheng, Ruijin, Dragomir, Ana-Cristina, Mishin, Vladimir, Richardson, Jason R., Heck, Diane E., Laskin, Debra L., Laskin, Jeffrey D.

“…The lipid peroxidation end-product 4-hydroxynonenal (4-HNE) is generated in tissues during oxidative stress. As a reactive aldehyde, it forms Michael adducts…”
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Sulfur mustard-induced pulmonary injury: Therapeutic approaches to mitigating toxicity by Weinberger, Barry, Laskin, Jeffrey D, Sunil, Vasanthi R, Sinko, Patrick J, Heck, Diane E, Laskin, Debra L

“…Abstract Sulfur mustard (SM) is highly toxic to the lung inducing both acute and chronic effects including upper and lower obstructive disease, airway…”
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Quinone and nitrofurantoin redox cycling by recombinant cytochrome b5 reductase by Szilagyi, John T., Fussell, Karma C., Wang, Yun, Jan, Yi-Hua, Mishin, Vladimir, Richardson, Jason R., Heck, Diane E., Yang, Shaojun, Aleksunes, Lauren M., Laskin, Debra L., Laskin, Jeffrey D.

“…NADH cytochrome b5 reductase mediates electron transfer from NADH to cytochrome b5 utilizing flavin adenine dinucleotide as a redox cofactor. Reduced…”
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Nrf2 Regulates the Sensitivity of Mouse Keratinocytes to Nitrogen Mustard via Multidrug Resistance-Associated Protein 1 (Mrp1) by Udasin, Ronald G, Wen, Xia, Bircsak, Kristin M, Aleksunes, Lauren M, Shakarjian, Michael P, Kong, Ah-Ng Tony, Heck, Diane E, Laskin, Debra L, Laskin, Jeffrey D

“…Sulfur mustard and nitrogen mustard (mechlorethamine, HN2) are potent vesicants developed as chemical warfare agents. These electrophilic, bifunctional…”
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UVB light regulates expression of antioxidants and inflammatory mediators in human corneal epithelial cells by Black, Adrienne T., Gordon, Marion. K., Heck, Diane E., Gallo, Michael A., Laskin, Debra L., Laskin, Jeffrey D.

“…The cornea is highly sensitive to ultraviolet B (UVB) light-induced oxidative stress, a process that results in the production of inflammatory mediators which…”
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Sulfa drugs inhibit sepiapterin reduction and chemical redox cycling by sepiapterin reductase by Yang, Shaojun, Jan, Yi-Hua, Mishin, Vladimir, Richardson, Jason R, Hossain, Muhammad M, Heindel, Ned D, Heck, Diane E, Laskin, Debra L, Laskin, Jeffrey D

“…Sepiapterin reductase (SPR) catalyzes the reduction of sepiapterin to dihydrobiopterin (BH2), the precursor for tetrahydrobiopterin (BH4), a cofactor critical…”
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Characterization of the Oxidase Activity in Mammalian Catalase by Vetrano, Anna M., Heck, Diane E., Mariano, Thomas M., Mishin, Vladimir, Laskin, Debra L., Laskin, Jeffrey D.

“…Catalase is a highly conserved heme-containing antioxidant enzyme known for its ability to degrade hydrogen peroxide into water and oxygen. In low…”
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Regulation of keratinocyte expression of stress proteins and antioxidants by the electrophilic nitrofatty acids 9- and 10-nitrooleic acid by Zheng, Ruijin, Heck, Diane E., Black, Adrienne T., Gow, Andrew, Laskin, Debra L., Laskin, Jeffrey D.

“…Nitric oxide and various by-products including nitrite contribute to tissue injury by forming novel intermediates via redox-mediated nitration reactions…”
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Solar ultraviolet radiation as a trigger of cell signal transduction by Heck, Diane E, Gerecke, Donald R, Vetrano, Anna M, Laskin, Jeffrey D

“…Ultraviolet light radiation in sunlight is known to cause major alterations in growth and differentiation patterns of exposed human tissues. The specific…”
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Regulation of Hsp27 and Hsp70 expression in human and mouse skin construct models by caveolae following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide by Black, Adrienne T., Hayden, Patrick J., Casillas, Robert P., Heck, Diane E., Gerecke, Donald R., Sinko, Patrick J., Laskin, Debra L., Laskin, Jeffrey D.

“…Dermal exposure to the vesicant sulfur mustard causes marked inflammation and tissue damage. Basal keratinocytes appear to be a major target of sulfur mustard…”
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Role of cytochrome P450 reductase in nitrofurantoin-induced redox cycling and cytotoxicity by Wang, Yun, Gray, Joshua P., Mishin, Vladimir, Heck, Diane E., Laskin, Debra L., Laskin, Jeffrey D.

“…The one-electron reduction of redox‐active chemotherapeutic agents generates highly toxic radical anions and reactive oxygen intermediates (ROI). A major…”
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DNA damage signaling in the cellular responses to mustard vesicants by Jan, Yi-Hua, Heck, Diane E., Laskin, Debra L., Laskin, Jeffrey D.

“…•Mustard vesicants such as sulfur mustard and nitrogen mustard are highly reactive with DNA.•Mustards can form monofunctional and bifunctional adducts.•Cells…”
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Distinct effects of form selective cytochrome P450 inhibitors on cytochrome P450-mediated monooxygenase and hydrogen peroxide generating NADPH oxidase by Mishin, Vladimir, Heck, Diane E., Jan, Yi-Hua, Richardson, Jason R., Laskin, Jeffrey D.

“…A characteristic of cytochrome P450 (CYP) enzymes is their ability to generate H2O2, either directly or indirectly via superoxide anion, a reaction referred to…”
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UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes by Black, Adrienne T., Gray, Joshua P., Shakarjian, Michael P., Mishin, Vladimir, Laskin, Debra L., Heck, Diane E., Laskin, Jeffrey D.

“…Prostaglandins belong to a class of cyclic lipid-derived mediators synthesized from arachidonic acid via COX-1, COX-2 and various prostaglandin synthases…”
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Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes by Jan, Yi-Hua, Heck, Diane E, An, Yunqi, Laskin, Debra L, Laskin, Jeffrey D

“…Cytotoxic blistering agents such as sulfur mustard and nitrogen mustard (HN2) were synthesized for chemical warfare. Toxicity is due to reactive chloroethyl…”
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Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progression via the DNA Damage Response in Human Lung Epithelial A549 Cells by Jan, Yi-Hua, Heck, Diane E, Laskin, Debra L, Laskin, Jeffrey D

“…Nitrogen mustard, mechlorethamine (bis­(2-chloroethyl)­methylamine; HN2), and sulfur mustard are potent vesicants that modify and disrupt cellular…”
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Mustard vesicant-induced lung injury: Advances in therapy by Weinberger, Barry, Malaviya, Rama, Sunil, Vasanthi R., Venosa, Alessandro, Heck, Diane E., Laskin, Jeffrey D., Laskin, Debra L.

“…Most mortality and morbidity following exposure to vesicants such as sulfur mustard is due to pulmonary toxicity. Acute injury is characterized by epithelial…”
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