Search Results - "Hecht, M"

Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting by Chevalier, Arnaud, Zhang, Yanmin, Khdour, Omar M, Kaye, Justin B, Hecht, Sidney M

“…Nitroreductase (NTR) activities have been known for decades, studied extensively in bacteria and also in systems as diverse as yeast, trypanosomes, and hypoxic…”
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Expanding the Scope of Protein Synthesis Using Modified Ribosomes by Dedkova, Larisa M, Hecht, Sidney M

“…The ribosome produces all of the proteins and many of the peptides present in cells. As a macromolecular complex composed of both RNAs and proteins, it employs…”
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Feasibility of continuous fever monitoring using wearable devices by Smarr, Benjamin L., Aschbacher, Kirstin, Fisher, Sarah M., Chowdhary, Anoushka, Dilchert, Stephan, Puldon, Karena, Rao, Adam, Hecht, Frederick M., Mason, Ashley E.

“…Elevated core temperature constitutes an important biomarker for COVID-19 infection; however, no standards currently exist to monitor fever using wearable…”
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Detection of Perchlorate and the Soluble Chemistry of Martian Soil at the Phoenix Lander Site by Hecht, M.H, Kounaves, S.P, Quinn, R.C, West, S.J, Young, S.M.M, Ming, D.W, Catling, D.C, Clark, B.C, Boynton, W.V, Hoffman, J, DeFlores, L.P, Gospodinova, K, Kapit, J, Smith, P.H

“…The Wet Chemistry Laboratory on the Phoenix Mars Lander performed aqueous chemical analyses of martian soil from the polygon-patterned northern plains of the…”
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Overall Survival, Disease-Free Survival, Local Recurrence, and Nipple–Areolar Recurrence in the Setting of Nipple-Sparing Mastectomy: A Meta-Analysis and Systematic Review by De La Cruz, Lucy, Moody, Alison M., Tappy, Erryn E., Blankenship, Stephanie A., Hecht, Eric M.

“…Background Nipple-sparing mastectomy (NSM) is an increasingly common procedure; however, concerns exist regarding its oncological safety due to the potential…”
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CD4+ T Cells Expressing PD-1, TIGIT and LAG-3 Contribute to HIV Persistence during ART by Fromentin, Rémi, Bakeman, Wendy, Lawani, Mariam B, Khoury, Gabriela, Hartogensis, Wendy, DaFonseca, Sandrina, Killian, Marisela, Epling, Lorrie, Hoh, Rebecca, Sinclair, Elizabeth, Hecht, Frederick M, Bacchetti, Peter, Deeks, Steven G, Lewin, Sharon R, Sékaly, Rafick-Pierre, Chomont, Nicolas

“…HIV persists in a small pool of latently infected cells despite antiretroviral therapy (ART). Identifying cellular markers expressed at the surface of these…”
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PD-1 blockade potentiates HIV latency reversal ex vivo in CD4+ T cells from ART-suppressed individuals by Fromentin, Rémi, DaFonseca, Sandrina, Costiniuk, Cecilia T., El-Far, Mohamed, Procopio, Francesco Andrea, Hecht, Frederick M., Hoh, Rebecca, Deeks, Steven G., Hazuda, Daria J., Lewin, Sharon R., Routy, Jean-Pierre, Sékaly, Rafick-Pierre, Chomont, Nicolas

“…HIV persists in latently infected CD4 + T cells during antiretroviral therapy (ART). Immune checkpoint molecules, including PD-1, are preferentially expressed…”
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Extent of Signal Hyperintensity on Unenhanced T1-weighted Brain MR Images after More than 35 Administrations of Linear Gadolinium-based Contrast Agents by Zhang, Yang, Cao, Yan, Shih, George L, Hecht, Elizabeth M, Prince, Martin R

“…Purpose To explore the extent of signal hyperintensity in the brain on unenhanced T1-weighted magnetic resonance (MR) images with increasing gadolinium-based…”
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Identification of Genetically Intact HIV-1 Proviruses in Specific CD4+ T Cells from Effectively Treated Participants by Hiener, Bonnie, Horsburgh, Bethany A., Eden, John-Sebastian, Barton, Kirston, Schlub, Timothy E., Lee, Eunok, von Stockenstrom, Susanne, Odevall, Lina, Milush, Jeffrey M., Liegler, Teri, Sinclair, Elizabeth, Hoh, Rebecca, Boritz, Eli A., Douek, Daniel, Fromentin, Rémi, Chomont, Nicolas, Deeks, Steven G., Hecht, Frederick M., Palmer, Sarah

“…Latent replication-competent HIV-1 persists in individuals on long-term antiretroviral therapy (ART). We developed the Full-Length Individual Proviral…”
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2017 Version of LI-RADS for CT and MR Imaging: An Update by Elsayes, Khaled M, Hooker, Jonathan C, Agrons, Michelle M, Kielar, Ania Z, Tang, An, Fowler, Kathryn J, Chernyak, Victoria, Bashir, Mustafa R, Kono, Yuko, Do, Richard K, Mitchell, Donald G, Kamaya, Aya, Hecht, Elizabeth M, Sirlin, Claude B

“…The Liver Imaging Reporting and Data System (LI-RADS) is a reporting system created for the standardized interpretation of liver imaging findings in patients…”
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Atmospheric origins of perchlorate on Mars and in the Atacama by Catling, D. C., Claire, M. W., Zahnle, K. J., Quinn, R. C., Clark, B. C., Hecht, M. H., Kounaves, S.

“…Isotopic studies indicate that natural perchlorate is produced on Earth in arid environments by the oxidation of chlorine species through pathways involving…”
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In Cellulo Synthesis of Proteins Containing a Fluorescent Oxazole Amino Acid by Chen, Shengxi, Ji, Xun, Gao, Mingxuan, Dedkova, Larisa M, Hecht, Sidney M

“…Genetic code expansion has enabled many noncanonical amino acids to be incorporated into proteins in vitro and in cellulo. These have largely involved…”
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Selective Tumor Cell Targeting by the Disaccharide Moiety of Bleomycin by Yu, Zhiqiang, Schmaltz, Ryan M, Bozeman, Trevor C, Paul, Rakesh, Rishel, Michael J, Tsosie, Krystal S, Hecht, Sidney M

“…In a recent study, the well-documented tumor targeting properties of the antitumor agent bleomycin (BLM) were studied in cell culture using microbubbles that…”
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Response of the Atlantic Ocean circulation to Greenland Ice Sheet melting in a strongly-eddying ocean model by Weijer, W., Maltrud, M. E., Hecht, M. W., Dijkstra, H. A., Kliphuis, M. A.

“…The sensitivity of the Atlantic Meridional Overturning Circulation (AMOC) to high‐latitude freshwater input is one of the key uncertainties in the climate…”
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Imaging viscoelastic properties of live cells by AFM: power-law rheology on the nanoscale by Hecht, Fabian M, Rheinlaender, Johannes, Schierbaum, Nicolas, Goldmann, Wolfgang H, Fabry, Ben, Schäffer, Tilman E

“…We developed force clamp force mapping (FCFM), an atomic force microscopy (AFM) technique for measuring the viscoelastic creep behavior of live cells with…”
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Plasma proteomic profiles differ between European and North American myotid bats colonized by Pseudogymnoascus destructans by Hecht‐Höger, Alexander M., Braun, Beate C., Krause, Eberhard, Meschede, Angelika, Krahe, Rüdiger, Voigt, Christian C., Greenwood, Alex D., Czirják, Gábor Á.

“…Emerging fungal diseases have become challenges for wildlife health and conservation. North American hibernating bat species are threatened by the…”
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Evidence for Calcium Carbonate at the Mars Phoenix Landing Site by Boynton, W.V, Ming, D.W, Kounaves, S.P, Young, S.M.M, Arvidson, R.E, Hecht, M.H, Hoffman, J, Niles, P.B, Hamara, D.K, Quinn, R.C, Smith, P.H, Sutter, B, Catling, D.C, Morris, R.V

“…Carbonates are generally products of aqueous processes and may hold important clues about the history of liquid water on the surface of Mars. Calcium carbonate…”
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HIV-infected individuals with low CD4/CD8 ratio despite effective antiretroviral therapy exhibit altered T cell subsets, heightened CD8+ T cell activation, and increased risk of non-AIDS morbidity and mortality by Serrano-Villar, Sergio, Sainz, Talia, Lee, Sulggi A, Hunt, Peter W, Sinclair, Elizabeth, Shacklett, Barbara L, Ferre, April L, Hayes, Timothy L, Somsouk, Ma, Hsue, Priscilla Y, Van Natta, Mark L, Meinert, Curtis L, Lederman, Michael M, Hatano, Hiroyu, Jain, Vivek, Huang, Yong, Hecht, Frederick M, Martin, Jeffrey N, McCune, Joseph M, Moreno, Santiago, Deeks, Steven G

“…A low CD4/CD8 ratio in elderly HIV-uninfected adults is associated with increased morbidity and mortality. A subset of HIV-infected adults receiving effective…”
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TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection by Chew, Glen M, Fujita, Tsuyoshi, Webb, Gabriela M, Burwitz, Benjamin J, Wu, Helen L, Reed, Jason S, Hammond, Katherine B, Clayton, Kiera L, Ishii, Naoto, Abdel-Mohsen, Mohamed, Liegler, Teri, Mitchell, Brooks I, Hecht, Frederick M, Ostrowski, Mario, Shikuma, Cecilia M, Hansen, Scott G, Maurer, Mark, Korman, Alan J, Deeks, Steven G, Sacha, Jonah B, Ndhlovu, Lishomwa C

“…HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors…”
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Incomplete Peripheral CD4+ Cell Count Restoration in HIV-Infected Patients Receiving Long-Term Antiretroviral Treatment by Kelley, Colleen F., Kitchen, Christina M. R., Hunt, Peter W., Rodriguez, Benigno, Hecht, Frederick M., Kitahata, Mari, Crane, Heide M., Willig, James, Mugavero, Michael, Saag, Michael, Martin, Jeffrey N., Deeks, Steven G.

“…Background.Although antiretroviral therapy has the ability to fully restore a normal CD4+ cell count (>500 cells/mm3) in most patients, it is not yet clear…”
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