Search Results - "Hebert, T E"

The amidated PACAP1–23 fragment is a potent reduced-size neuroprotective agent by Lamine, A., Poujol de Molliens, M., Létourneau, M., Hébert, T.E., Vaudry, D., Fournier, A., Chatenet, D.

“…Neurodegenerative disorders, such as Parkinson's disease (PD), are characterized by neuronal death involving, among other events, mitochondrial dysfunction and…”
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Functional selectivity in GPCR signaling: understanding the full spectrum of receptor conformations by Goupil, E, Laporte, S A, Hébert, T E

“…The great versatility of G protein-coupled receptors (GPCRs), in terms of both their ability to bind different types of ligands and initiate a large number of…”
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Inverse agonist activity of beta-adrenergic antagonists by Chidiac, P, Hebert, T E, Valiquette, M, Dennis, M, Bouvier, M

“…Agonist-independent properties of the human beta 2-adrenergic receptor (beta 2AR) were studied using the baculovirus expression system in Sf9 cells. In the…”
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Gamma-aminobutyric acid type B receptors with specific heterodimer composition and postsynaptic actions in hippocampal neurons are targets of anticonvulsant gabapentin action by Ng, G Y, Bertrand, S, Sullivan, R, Ethier, N, Wang, J, Yergey, J, Belley, M, Trimble, L, Bateman, K, Alder, L, Smith, A, McKernan, R, Metters, K, O'Neill, G P, Lacaille, J C, Hébert, T E

“…Gamma-aminobutyric acid (GABA) activates two qualitatively different inhibitory mechanisms through ionotropic GABA(A) multisubunit chloride channel receptors…”
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Cost and demand analysis of excimer laser use: first World Wide Web Internet survey of the interest in refractive surgery by Borer, M J, Hebert, T E, Breshears, D

“…To determine the actual size of the refractive surgery market in the United States and to identify factors involved in the decision to have refractive surgery…”
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Structural and functional aspects of G protein-coupled receptor oligomerization by Hébert, T E, Bouvier, M

“…G protein-coupled receptors (GPCRs) represent the single largest family of cell surface receptors involved in signal transduction. It is estimated that several…”
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Voltage Dependencies of the Fast and Slow Gating Modes of RIIA Sodium Channels by Hebert, Terence E., Monette, Robert, Dunn, Robert J., Drapeau, Pierre

“…Rat brain IIA sodium channel $\alpha $-subunits were expressed in Xenopus oocytes, and the sodium currents were measured by intracellular voltage clamping with…”
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A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link? by Weerapura, Manjula, Nattel, Stanley, Chartier, Denis, Caballero, Ricardo, Hébert, Terence E.

“…Although it has been suggested that coexpression of minK related peptide (MiRP1) is required for reconstitution of native rapid delayed-rectifier current ( I…”
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Novel tools for use in bioluminescence resonance energy transfer (BRET) assays by Robitaille, Mélanie, Héroux, Isabelle, Baragli, Alessandra, Hébert, Terence E

“…Recent advances in imaging assays based on bioluminescence resonance energy transfer (BRET) have made it possible to study protein/protein interactions in…”
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Dofetilide block involves interactions with open and inactivated states of HERG channels by Weerapura, Manjula, Hébert, Terence E, Nattel, Stanley

“…Rapidly activating delayed rectifier current ( IKr) is the key target of class III antiarrhythmic drugs including dofetilide. Due to its complex gating…”
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Insertion mutations of the RIIA Na+ channel reveal novel features of voltage gating and protein kinase A modulation by HEBERT, T. E, MONETTE, R, STONE, J. C, DRAPEAU, P, DUNN, R. J

“…A linker insertion mutagenesis strategy was developed to probe functional subdomains of the RIIA Na+ channel alpha-subunit. We describe mutations within the…”
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Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor by Sullivan, R, Chateauneuf, A, Coulombe, N, Kolakowski, Jr, L F, Johnson, M P, Hebert, T E, Ethier, N, Belley, M, Metters, K, Abramovitz, M, O'Neill, G P, Ng, G Y

“…Direct evidence is lacking to show whether the gamma-aminobutyric acid (GABA)(B) gb1-gb2 heterodimer is the signaling form of the receptor. In this study, we…”
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Dihydropyridine and beta adrenergic receptor binding in dogs with tachycardia-induced atrial fibrillation by Gaspo, R, Sun, H, Fareh, S, Levi, M, Yue, L, Allen, B G, Hebert, T E, Nattel, S

“…We have shown that rapid atrial activation, as occurs during atrial fibrillation (AF), reduces L-type Ca2+ current (ICa) and that this is the principal…”
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Signalling in cardiac disease: the molecular deficit at the heart of the problem by Hébert, T E

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Co-expression of Human Kir3 Subunits Can Yield Channels with Different Functional Properties by Schoots, Oscar, Wilson, Julie M, Ethier, Nathalie, Bigras, Eve, Hebert, Terence E, Van Tol, Hubert H.M

“…To date, no comprehensive study has been done on all combinations of the human homologues of the Kir3.0 channel family, and the human homologue of Kir3.3 has…”
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Inhibition of staphylococcal alpha-toxin by covalent modification of an arginine residue by Hebert, T E, Fackrell, H B

“…The effects of 1,2-cyclohexanedione and phenylglyoxal on staphylococcal alpha-toxin were studied. Modification of one arginine residue in alpha-toxin was…”
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Dynamic palmitoylation of G-protein-coupled receptors in eukaryotic cells by Bouvier, M, Chidiac, P, Hebert, T E, Loisel, T P, Moffett, S, Mouillac, B

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Involvement of lipid rafts and caveolae in cardiac ion channel function by Maguy, Ange, Hebert, Terence E, Nattel, Stanley

“…A variety of lipid microdomains, including caveolae, have been shown to play an important role in both protein targetting and in controlling protein-protein…”
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Real-time monitoring of receptor and G-protein interactions in living cells by Bouvier, Michel, Galés, Céline, Rebois, R Victor, Hogue, Mireille, Trieu, Phan, Breit, Andreas, Hébert, Terence E

“…G protein-coupled receptors (GPCRs) represent the largest family of proteins involved in signal transduction. Here we present a bioluminescence resonance…”
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Functional Selectivity Revealed by N‑Methylation Scanning of Human Urotensin II and Related Peptides by Merlino, Francesco, Billard, Étienne, Yousif, Ali M, Di Maro, Salvatore, Brancaccio, Diego, Abate, Luigi, Carotenuto, Alfonso, Bellavita, Rosa, d’Emmanuele di Villa Bianca, Roberta, Santicioli, Paolo, Marinelli, Luciana, Novellino, Ettore, Hébert, Terence E, Lubell, William D, Chatenet, David, Grieco, Paolo

“…In accordance with their common but also divergent physiological actions, human urotensin II (1) and urotensin II-related peptide (2) could stabilize specific…”
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