Search Results - "Hebert, S"

Alterations of the microRNA network cause neurodegenerative disease by Hébert, Sébastien S, De Strooper, Bart

“…Brain development crucially depends on the integrity of microRNA (miRNA) pathways, which function at the post-transcriptional level as a rheostat of the…”
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MicroRNAs in Alzheimer's disease by Delay, Charlotte, Mandemakers, Wim, Hébert, Sébastien S

“…Abstract Alzheimer's disease (AD) is a complex neurodegenerative disorder and is the most common form of dementia in the elderly. Accumulating evidence in AD…”
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In vivo regulation of amyloid precursor protein neuronal splicing by microRNAs by Smith, Pascal, Al Hashimi, Amelle, Girard, Johanne, Delay, Charlotte, Hébert, Sébastien S.

“…J. Neurochem. (2011) 116, 240–247. The β‐amyloid peptide that accumulate in Alzheimer’s disease (AD) brain derive from proteolytic processing of the amyloid…”
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Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis by Riley, Nicholas M., Hebert, Alexander S., Westphall, Michael S., Coon, Joshua J.

“…Protein glycosylation is a highly important, yet poorly understood protein post-translational modification. Thousands of possible glycan structures and…”
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Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration by Hébert, Sébastien S., Papadopoulou, Aikaterini S., Smith, Pascal, Galas, Marie-Christine, Planel, Emmanuel, Silahtaroglu, Asli N., Sergeant, Nicolas, Buée, Luc, De Strooper, Bart

“…Type III RNase Dicer is responsible for the maturation and function of microRNA (miRNA) molecules in the cell. It is now well-documented that Dicer and the…”
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The miR-15/107 Group of MicroRNA Genes: Evolutionary Biology, Cellular Functions, and Roles in Human Diseases by Finnerty, John R., Wang, Wang-Xia, Hébert, Sébastien S., Wilfred, Bernard R., Mao, Guogen, Nelson, Peter T.

“…The miR-15/107 group of microRNA (miRNA) gene is increasingly appreciated to serve key functions in humans. These miRNAs regulate gene expression involved in…”
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A Novel MicroRNA-124/PTPN1 Signal Pathway Mediates Synaptic and Memory Deficits in Alzheimer’s Disease by Wang, Xiong, Liu, Dan, Huang, He-Zhou, Wang, Zhi-Hao, Hou, Tong-Yao, Yang, Xin, Pang, Pei, Wei, Na, Zhou, Ya-Fan, Dupras, Marie-Josée, Calon, Frédéric, Wang, Yu-Tian, Man, Heng-Ye, Chen, Jian-Guo, Wang, Jian-Zhi, Hébert, Sébastien S., Lu, Youming, Zhu, Ling-Qiang

“…Synaptic loss is an early pathological event in Alzheimer’s disease (AD), but its underlying molecular mechanisms remain largely unknown. Recently, microRNAs…”
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MicroRNA regulation of Alzheimer's Amyloid precursor protein expression by Hébert, Sébastien S, Horré, Katrien, Nicolaï, Laura, Bergmans, Bruno, Papadopoulou, Aikaterini S, Delacourte, André, De Strooper, Bart

“…Abstract Gene dosage effects of Amyloid precursor protein ( APP ) can cause familial AD. Recent evidence suggest that microRNA (miRNA) pathways, implicated in…”
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Co-occurrence of mixed proteinopathies in late-stage Huntington’s disease by St-Amour, Isabelle, Turgeon, Andréanne, Goupil, Claudia, Planel, Emmanuel, Hébert, Sébastien S.

“…Accumulating evidence highlights the potential role of mixed proteinopathies (i.e., abnormal protein aggregation) in the development of clinical manifestations…”
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Global detection of human variants and isoforms by deep proteome sequencing by Sinitcyn, Pavel, Richards, Alicia L., Weatheritt, Robert J., Brademan, Dain R., Marx, Harald, Shishkova, Evgenia, Meyer, Jesse G., Hebert, Alexander S., Westphall, Michael S., Blencowe, Benjamin J., Cox, Jürgen, Coon, Joshua J.

“…An average shotgun proteomics experiment detects approximately 10,000 human proteins from a single sample. However, individual proteins are typically…”
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MicroRNAs underlying memory deficits in neurodegenerative disorders by Hernandez-Rapp, Julia, Rainone, Sara, Hébert, Sébastien S.

“…Neurodegenerative disorders are defined by neuronal loss and often associated with dementia. Understanding the multifactorial nature of cognitive decline is of…”
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Now, More Than Ever, Proteomics Needs Better Chromatography by Shishkova, Evgenia, Hebert, Alexander S, Coon, Joshua J

“…From plant research to biomedicine, proteome analysis plays a critical role in many areas of biological inquiry. Steady improvement in mass spectrometer (MS)…”
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Differential Regulation of Tau Exon 2 and 10 Isoforms in Huntington’s Disease Brain by Petry, Serena, Nateghi, Behnaz, Keraudren, Rémi, Sergeant, Nicolas, Planel, Emmanuel, Hébert, Sébastien S., St-Amour, Isabelle

“…•Huntington’s disease is associated with deficits in MAPT alternative splicing.•Higher tau exon 10 inclusion is a common trait of HD and consistently observed…”
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Use of optical motion capture for the analysis of normative upper body kinematics during functional upper limb tasks: A systematic review by Valevicius, Aïda M., Jun, Peter Y., Hebert, Jacqueline S., Vette, Albert H.

“…Quantifying three-dimensional upper body kinematics can be a valuable method for assessing upper limb function. Considering that kinematic model…”
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Global mapping of CARM1 substrates defines enzyme specificity and substrate recognition by Shishkova, Evgenia, Zeng, Hao, Liu, Fabao, Kwiecien, Nicholas W., Hebert, Alexander S., Coon, Joshua J., Xu, Wei

“…Protein arginine methyltransferases (PRMTs) introduce arginine methylation, a post-translational modification with the increasingly eminent role in normal…”
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MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy by Smith, Pascal Y., Delay, Charlotte, Girard, Johanne, Papon, Marie-Amélie, Planel, Emmanuel, Sergeant, Nicolas, Buée, Luc, Hébert, Sébastien S.

“…Tauopathies represent a large class of neurological and movement disorders characterized by abnormal intracellular deposits of the microtubule-associated…”
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Memory formation and retention are affected in adult miR-132/212 knockout mice by Hernandez-Rapp, Julia, Smith, Pascal Y., Filali, Mohammed, Goupil, Claudia, Planel, Emmanuel, Magill, Stephen T., Goodman, Richard H., Hébert, Sébastien S.

“…•MiR-132/212 knockout mice are deficient in spatial memory and learning.•MiR-132/212 knockout mice presented impairments in novel object recognition.•Anxiety,…”
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Characterization of normative hand movements during two functional upper limb tasks by Valevicius, Aïda M, Boser, Quinn A, Lavoie, Ewen B, Murgatroyd, Glyn S, Pilarski, Patrick M, Chapman, Craig S, Vette, Albert H, Hebert, Jacqueline S

“…Dexterous hand function is crucial for completing activities of daily living (ADLs), which typically require precise hand-object interactions. Kinematic…”
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Preclinical Evaluation of miR-15/107 Family Members as Multifactorial Drug Targets for Alzheimer's Disease by Parsi, Sepideh, Smith, Pascal Y, Goupil, Claudia, Dorval, Véronique, Hébert, Sébastien S

“…Alzheimer's disease (AD) is a multifactorial, fatal neurodegenerative disorder characterized by the abnormal accumulation of Aβ and Tau deposits in the brain…”
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Prenatal Immune Challenge in Mice Leads to Partly Sex-Dependent Behavioral, Microglial, and Molecular Abnormalities Associated with Schizophrenia by Hui, Chin W, St-Pierre, Abygaël, El Hajj, Hassan, Remy, Yvan, Hébert, Sébastien S, Luheshi, Giamal N, Srivastava, Lalit K, Tremblay, Marie-Ève

“…Epidemiological studies revealed that environmental factors comprising prenatal infection are strongly linked to risk for later development of neuropsychiatric…”
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