Search Results - "Hebels, Dennie G A"

Dynamic adaptation of mesenchymal stem cell physiology upon exposure to surface micropatterns by Beijer, Nick R. M., Nauryzgaliyeva, Zarina M., Arteaga, Estela M., Pieuchot, Laurent, Anselme, Karine, van de Peppel, Jeroen, Vasilevich, Aliaksei S., Groen, Nathalie, Roumans, Nadia, Hebels, Dennie G. A. J., Boer, Jan de

“…Human mesenchymal stem (hMSCs) are defined as multi-potent colony-forming cells expressing a specific subset of plasma membrane markers when grown on flat…”
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On the correlation between material-induced cell shape and phenotypical response of human mesenchymal stem cells by Vasilevich, Aliaksei S., Vermeulen, Steven, Kamphuis, Marloes, Roumans, Nadia, Eroumé, Said, Hebels, Dennie G. A. J., van de Peppel, Jeroen, Reihs, Rika, Beijer, Nick R. M., Carlier, Aurélie, Carpenter, Anne E., Singh, Shantanu, de Boer, Jan

“…Learning rules by which cell shape impacts cell function would enable control of cell physiology and fate in medical applications, particularly, on the…”
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Identification of Sex-Specific Transcriptome Responses to Polychlorinated Biphenyls (PCBs) by Espín-Pérez, Almudena, Hebels, Dennie G. A. J., Kiviranta, Hannu, Rantakokko, Panu, Georgiadis, Panagiotis, Botsivali, Maria, Bergdahl, Ingvar A., Palli, Domenico, Späth, Florentin, Johansson, Anders, Chadeau-Hyam, Marc, Kyrtopoulos, Soterios A., Kleinjans, Jos C. S., de Kok, Theo M. C. M.

“…PCBs are classified as xenoestrogens and carcinogens and their health risks may be sex-specific. To identify potential sex-specific responses to PCB-exposure…”
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Associations Between Genome-wide Gene Expression and Ambient Nitrogen Oxides by Mostafavi, Nahid, Vlaanderen, Jelle, Portengen, Lutzen, Chadeau-Hyam, Marc, Modig, Lars, Palli, Domenico, Bergdahl, Ingvar A., Brunekreef, Bert, Vineis, Paolo, Hebels, Dennie G. A. J., Kleinjans, Jos C. S., Krogh, Vittorio, Hoek, Gerard, Georgiadis, Panagiotis, Kyrtopoulos, Soterios A., Vermeulen, Roel

“…BACKGROUND:We hypothesize that biological perturbations due to exposure to ambient air pollution are reflected in gene-expression levels in peripheral blood…”
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Binary PAH mixtures cause additive or antagonistic effects on gene expression but synergistic effects on DNA adduct formation by Staal, Yvonne C.M., Hebels, Dennie G.A.J., van Herwijnen, Marcel H.M., Gottschalk, Ralph W.H., van Schooten, Frederik J., van Delft, Joost H.M.

“…Polycyclic aromatic hydrocarbons (PAHs) cover a wide range of structurally related compounds which differ greatly in their carcinogenic potency. PAH exposure…”
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Red meat intake-induced increases in fecal water genotoxicity correlate with pro-carcinogenic gene expression changes in the human colon by Hebels, Dennie G.A.J., Sveje, Kirstine M., de Kok, Marloes C., van Herwijnen, Marcel H.M., Kuhnle, Gunter G.C., Engels, Leopold G.J.B., Vleugels-Simon, Carla B.E.M., Mares, Wout G.N., Pierik, Marieke, Masclee, Ad A.M., Kleinjans, Jos C.S., de Kok, Theo M.C.M.

“…► Fecal water genotoxicity significantly increased after an increase in red meat intake to 300g/day for 7days. ► Oxidative DNA damage is a large contributor to…”
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Radical mechanisms in nitrosamine- and nitrosamide-induced whole-genome gene expression modulations in Caco-2 cells by Hebels, Dennie G A J, Briedé, Jacob J, Khampang, Roongnapa, Kleinjans, Jos C S, de Kok, Theo M C M

“…N-nitroso compounds (NOCs) may be implicated in human colon carcinogenesis, but the toxicological mechanisms involved have not been elucidated. Because it was…”
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Mechanotransduction is a context-dependent activator of TGF-β signaling in mesenchymal stem cells by Vermeulen, Steven, Roumans, Nadia, Honig, Floris, Carlier, Aurélie, Hebels, Dennie G.A.J., Eren, Aysegul Dede, Dijke, Peter ten, Vasilevich, Aliaksei, de Boer, Jan

“…We previously found that surface topographies induce the expression of the Scxa gene, encoding Scleraxis in tenocytes. Because Scxa is a TGF-β responsive gene,…”
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Time-series analysis of gene expression profiles induced by nitrosamides and nitrosamines elucidates modes of action underlying their genotoxicity in human colon cells by Hebels, Dennie G.A.J., Brauers, Karen J.J., van Herwijnen, Marcel H.M., Georgiadis, Panagiotis A., Kyrtopoulos, Soterios A., Kleinjans, Jos C.S., de Kok, Theo M.C.M.

“…► Nitrosamines and nitrosamides differ in their temporal transcriptomic effects. ► Both NOC groups affect pathways related to carcinogenicity but at different…”
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DNA methylation and exposure to ambient air pollution in two prospective cohorts by Plusquin, Michelle, Guida, Florence, Polidoro, Silvia, Vermeulen, Roel, Raaschou-Nielsen, Ole, Campanella, Gianluca, Hoek, Gerard, Kyrtopoulos, Soterios A., Georgiadis, Panagiotis, Naccarati, Alessio, Sacerdote, Carlotta, Krogh, Vittorio, Bas Bueno-de-Mesquita, H., Monique Verschuren, W.M., Sayols-Baixeras, Sergi, Panni, Tommaso, Peters, Annette, Hebels, Dennie G.A.J., Kleinjans, Jos, Vineis, Paolo, Chadeau-Hyam, Marc

“…Long-term exposure to air pollution has been associated with several adverse health effects including cardiovascular, respiratory diseases and cancers…”
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Whole-genome gene expression modifications associated with nitrosamine exposure and micronucleus frequency in human blood cells by Hebels, Dennie G. A. J., Jennen, Danyel G. J., van Herwijnen, Marcel H. M., Moonen, Edwin J. C., Pedersen, Marie, Knudsen, Lisbeth E., Kleinjans, Jos C. S., de Kok, Theo M. C. M.

“…N-nitroso compounds (NOCs) are suspected human carcinogens and relevant in human exposure. NOCs also induce micronuclei (MN) formation in vivo. Since…”
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Linking the Transcriptional Landscape of Bone Induction to Biomaterial Design Parameters by Groen, Nathalie, Yuan, Huipin, Hebels, Dennie G. A. J., Koçer, Gülistan, Mbuyi, Faustin, LaPointe, Vanessa, Truckenmüller, Roman, van Blitterswijk, Clemens A., Habibović, Pamela, de Boer, Jan

“…New engineering possibilities allow biomaterials to serve as active orchestrators of the molecular and cellular events of tissue regeneration. Here, the…”
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cBiT: A transcriptomics database for innovative biomaterial engineering by Hebels, Dennie G.A.J., Carlier, Aurélie, Coonen, Maarten L.J., Theunissen, Daniël H., de Boer, Jan

“…Creating biomaterials that are suited for clinical application is still hampered by a lack of understanding of the interaction between a cell and the…”
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Evaluation of database-derived pathway development for enabling biomarker discovery for hepatotoxicity by Hebels, Dennie G A, Jetten, Marlon J A, Aerts, Hugo J W, Herwig, Ralf, Theunissen, Daniël H J, Gaj, Stan, van Delft, Joost H, Kleinjans, Jos C S

“…Current testing models for predicting drug-induced liver injury are inadequate, as they basically under-report human health risks. We present here an approach…”
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Performance in omics analyses of blood samples in long-term storage: opportunities for the exploitation of existing biobanks in environmental health research by Hebels, Dennie G A J, Georgiadis, Panagiotis, Keun, Hector C, Athersuch, Toby J, Vineis, Paolo, Vermeulen, Roel, Portengen, Lützen, Bergdahl, Ingvar A, Hallmans, Göran, Palli, Domenico, Bendinelli, Benedetta, Krogh, Vittorio, Tumino, Rosario, Sacerdote, Carlotta, Panico, Salvatore, Kleinjans, Jos C S, de Kok, Theo M C M, Smith, Martyn T, Kyrtopoulos, Soterios A

“…The suitability for omic analysis of biosamples collected in previous decades and currently stored in biobanks is unknown. We evaluated the influence of…”
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diXa: a data infrastructure for chemical safety assessment by Hendrickx, Diana M, Aerts, Hugo J W L, Caiment, Florian, Clark, Dominic, Ebbels, Timothy M D, Evelo, Chris T, Gmuender, Hans, Hebels, Dennie G A J, Herwig, Ralf, Hescheler, Jürgen, Jennen, Danyel G J, Jetten, Marlon J A, Kanterakis, Stathis, Keun, Hector C, Matser, Vera, Overington, John P, Pilicheva, Ekaterina, Sarkans, Ugis, Segura-Lepe, Marcelo P, Sotiriadou, Isaia, Wittenberger, Timo, Wittwehr, Clemens, Zanzi, Antonella, Kleinjans, Jos C S

“…The field of toxicogenomics (the application of '-omics' technologies to risk assessment of compound toxicities) has expanded in the last decade, partly driven…”
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Molecular Signatures of N-nitroso Compounds in Caco-2 Cells: Implications for Colon Carcinogenesis by Hebels, Dennie G. A. J., Jennen, Danyel G. J., Kleinjans, Jos C. S., de Kok, Theo M. C. M.

“…N-nitroso compounds (NOC) are genotoxic, carcinogenic to animals, and may play a role in human cancer development. Because the gastro-intestinal tract is an…”
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A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure by Hebels, Dennie G A J, Rasche, Axel, Herwig, Ralf, van Westen, Gerard J P, Jennen, Danyel G J, Kleinjans, Jos C S

“…When evaluating compound similarity, addressing multiple sources of information to reach conclusions about common pharmaceutical and/or toxicological…”
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N-nitroso compound exposure-associated transcriptomic profiles are indicative of an increased risk for colorectal cancer by Hebels, Dennie G.A.J, Sveje, Kirstine M, de Kok, Marloes C, van Herwijnen, Marcel H.M, Kuhnle, Gunter G.C, Engels, Leopold G.J.B, Vleugels-Simon, Carla B.E.M, Mares, Wout G.N, Pierik, Marieke, Masclee, Ad A.M, Kleinjans, Jos C.S, de Kok, Theo M.C.M

“…Abstract Endogenous formation of N-nitroso compounds (NOCs), which are known animal carcinogens, could contribute to human carcinogenesis but definitive…”
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Elimination of heparin interference during microarray processing of fresh and biobank-archived blood samples by Hebels, Dennie G.A.J., van Herwijnen, Marcel H.M., Brauers, Karen J.J., de Kok, Theo M.C.M., Chalkiadaki, Georgia, Kyrtopoulos, Soterios A., Kleinjans, Jos C.S.

“…In the context of environmental health research, biobank blood samples have recently been identified as suitable for high‐throughput omics analyses enabling…”
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