Search Results - "Hebbar, Prashantha"

SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains by Haddad, Dania, John, Sumi Elsa, Mohammad, Anwar, Hammad, Maha M, Hebbar, Prashantha, Channanath, Arshad, Nizam, Rasheeba, Al-Qabandi, Sarah, Al Madhoun, Ashraf, Alshukry, Abdullah, Ali, Hamad, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…COVID-19 is challenging healthcare preparedness, world economies, and livelihoods. The infection and death rates associated with this pandemic are strikingly…”
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Genome-wide landscape establishes novel association signals for metabolic traits in the Arab population by Hebbar, Prashantha, Abubaker, Jehad Ahmed, Abu-Farha, Mohamed, Alsmadi, Osama, Elkum, Naser, Alkayal, Fadi, John, Sumi Elsa, Channanath, Arshad, Iqbal, Rasheeba, Pitkaniemi, Janne, Tuomilehto, Jaakko, Sladek, Robert, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…While the Arabian population has a high prevalence of metabolic disorders, it has not been included in global studies that identify genetic risk loci for…”
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Unraveling a fine-scale high genetic heterogeneity and recent continental connections of an Arabian Peninsula population by Eaaswarkhanth, Muthukrishnan, Pathak, Ajai K, Ongaro, Linda, Montinaro, Francesco, Hebbar, Prashantha, Alsmadi, Osama, Metspalu, Mait, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…Recent studies have showed the diverse genetic architecture of the highly consanguineous populations inhabiting the Arabian Peninsula. Consanguinity coupled…”
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Linkage analysis using whole exome sequencing data implicates SLC17A1, SLC17A3, TATDN2 and TMEM131L in type 1 diabetes in Kuwaiti families by Hebbar, Prashantha, Nizam, Rasheeba, John, Sumi Elsa, Antony, Dinu, Dashti, Mohammad, Channanath, Arshad, Shaltout, Azza, Al-Khandari, Hessa, Koistinen, Heikki A., Tuomilehto, Jaakko, Alsmadi, Osama, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…Type 1 diabetes (T1D) is characterized by the progressive destruction of pancreatic β-cells, leading to insulin deficiency and lifelong dependency on exogenous…”
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Differentially methylated and expressed genes in familial type 1 diabetes by Dashti, Mohammed, Nizam, Rasheeba, Hebbar, Prashantha, Jacob, Sindhu, John, Sumi Elsa, Channanath, Arshad, Al-Kandari, Hessa, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…There has recently been a growing interest in examining the role of epigenetic modifications, such as DNA methylation, in the etiology of type 1 diabetes…”
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Genetic risk variants for metabolic traits in Arab populations by Hebbar, Prashantha, Elkum, Naser, Alkayal, Fadi, John, Sumi Elsa, Thanaraj, Thangavel Alphonse, Alsmadi, Osama

“…Despite a high prevalence of metabolic trait related diseases in Arabian Peninsula, there is a lack of convincingly identified genetic determinants for…”
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Prognostic Genetic Markers for Thrombosis in COVID-19 Patients: A Focused Analysis on D-Dimer, Homocysteine and Thromboembolism by Abu-Farha, Mohamed, Al-Sabah, Salman, Hammad, Maha M, Hebbar, Prashantha, Channanath, Arshad Mohamed, John, Sumi Elsa, Taher, Ibrahim, Almaeen, Abdulrahman, Ghazy, Amany, Mohammad, Anwar, Abubaker, Jehad, Arefanian, Hossein, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…COVID-19 is caused by Severe Acute Respiratory Syndrome Coronavirus-2, which has infected over thirty eight million individuals worldwide. Emerging evidence…”
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Genome-wide association study identifies novel recessive genetic variants for high TGs in an Arab population by Hebbar, Prashantha, Nizam, Rasheeba, Melhem, Motasem, Alkayal, Fadi, Elkum, Naser, John, Sumi Elsa, Tuomilehto, Jaakko, Alsmadi, Osama, Thanaraj, Thangavel Alphonse

“…Abnormal blood lipid levels are influenced by genetic and lifestyle/dietary factors. Although many genetic variants associated with blood lipid traits have…”
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Caveolin-1 rs1997623 variant and adult metabolic syndrome—Assessing the association in three ethnic cohorts of Arabs, South Asians and South East Asians by Al Madhoun, Ashraf, Hebbar, Prashantha, Nizam, Rasheeba, Haddad, Dania, Melhem, Motasem, Abu-Farha, Mohamed, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd

“…Background: Animal and cell model studies have implicated CAV1 in the pathophysiology of metabolic disorders. Our previous studies demonstrated a potential…”
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ESCC ATLAS: A population wide compendium of biomarkers for Esophageal Squamous Cell Carcinoma by Tungekar, Asna, Mandarthi, Sumana, Mandaviya, Pooja Rajendra, Gadekar, Veerendra P., Tantry, Ananthajith, Kotian, Sowmya, Reddy, Jyotshna, Prabha, Divya, Bhat, Sushma, Sahay, Sweta, Mascarenhas, Roshan, Badkillaya, Raghavendra Rao, Nagasampige, Manoj Kumar, Yelnadu, Mohan, Pawar, Harsh, Hebbar, Prashantha, Kashyap, Manoj Kumar

“…Esophageal cancer (EC) is the eighth most aggressive malignancy and its treatment remains a challenge due to the lack of biomarkers that can facilitate early…”
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Distribution of HLA-B Alleles and Haplotypes in Qatari: Recommendation for Establishing Pharmacogenomic Markers Screening for Drug Hypersensitivity by Dashti, Mohammed, Al-Matrouk, Abdullah, Channanath, Arshad, Hebbar, Prashantha, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…Human leukocyte antigen (HLA) proteins are present at the cellular surface of antigen-presenting cells and play a crucial role in the adaptive immune response…”
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Genetic substructure of Kuwaiti population reveals migration history by Alsmadi, Osama, Thareja, Gaurav, Alkayal, Fadi, Rajagopalan, Ramakrishnan, John, Sumi Elsa, Hebbar, Prashantha, Behbehani, Kazem, Thanaraj, Thangavel Alphonse

“…The State of Kuwait is characterized by settlers from Saudi Arabia, Iran, and other regions of the Arabian Peninsula. The settlements and subsequent admixtures…”
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Genome-wide association study identifies novel risk variants from RPS6KA1, CADPS, VARS, and DHX58 for fasting plasma glucose in Arab population by Hebbar, Prashantha, Abu-Farha, Mohamed, Alkayal, Fadi, Nizam, Rasheeba, Elkum, Naser, Melhem, Motasem, John, Sumi Elsa, Channanath, Arshad, Abubaker, Jehad, Bennakhi, Abdullah, Al-Ozairi, Ebaa, Tuomilehto, Jaakko, Pitkaniemi, Janne, Alsmadi, Osama, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…Consanguineous populations of the Arabian Peninsula, which has seen an uncontrolled rise in type 2 diabetes incidence, are underrepresented in global studies…”
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Genome at juncture of early human migration: a systematic analysis of two whole genomes and thirteen exomes from Kuwaiti population subgroup of inferred Saudi Arabian tribe ancestry by Alsmadi, Osama, John, Sumi E, Thareja, Gaurav, Hebbar, Prashantha, Antony, Dinu, Behbehani, Kazem, Thanaraj, Thangavel Alphonse

“…Population of the State of Kuwait is composed of three genetic subgroups of inferred Persian, Saudi Arabian tribe and Bedouin ancestry. The Saudi Arabian tribe…”
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The miR-668 binding site variant rs1046322 on WFS1 is associated with obesity in Southeast Asians by Hammad, Maha M., Abu-Farha, Mohamed, Hebbar, Prashantha, Anoop, Emil, Chandy, Betty, Melhem, Motasem, Channanath, Arshad, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse, Abubaker, Jehad

“…The Wolfram syndrome 1 gene ( WFS1) is the main causative locus for Wolfram syndrome, an inherited condition characterized by childhood-onset diabetes…”
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FTO Variant rs1421085 Associates With Increased Body Weight, Soft Lean Mass, and Total Body Water Through Interaction With Ghrelin and Apolipoproteins in Arab Population by Hebbar, Prashantha, Abu-Farha, Mohamed, Mohammad, Anwar, Alkayal, Fadi, Melhem, Motasem, Abubaker, Jehad, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…Association studies have implicated single nucleotide polymorphisms (SNPs), particularly rs1421085, from the fat mass and obesity-associated ( ) gene with body…”
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A Perception on Genome-Wide Genetic Analysis of Metabolic Traits in Arab Populations by Hebbar, Prashantha, Abubaker, Jehad Ahmed, Abu-Farha, Mohamed, Tuomilehto, Jaakko, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…Despite dedicated nation-wide efforts to raise awareness against the harmful effects of fast-food consumption and sedentary lifestyle, the Arab population…”
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Delineation of Mitochondrial DNA Variants From Exome Sequencing Data and Association of Haplogroups With Obesity in Kuwait by Dashti, Mohammed, Alsaleh, Hussain, Eaaswarkhanth, Muthukrishnan, John, Sumi Elsa, Nizam, Rasheeba, Melhem, Motasem, Hebbar, Prashantha, Sharma, Prem, Al-Mulla, Fahd, Thanaraj, Thangavel Alphonse

“…Whole-exome sequencing is a valuable tool to determine genetic variations that are associated with rare and common health conditions. A limited number of…”
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Global comparative transcriptomes uncover novel and population-specific gene expression in esophageal squamous cell carcinoma by Alotaibi, Amal, Gadekar, Veerendra P, Gundla, Pranav Swaroop, Mandarthi, Sumana, Jayendra, Nidhi, Tungekar, Asna, Lavanya, B. V, Bhagavath, Ashok Kumar, Cordero, Mary Anne Wong, Pitkaniemi, Janne, Niazi, Shaik Kalimulla, Upadhya, Raghavendra, Bepari, Asmatanzeem, Hebbar, Prashantha

“…Abstract Background Esophageal squamous cell carcinoma (ESCC) has a poor prognosis and is one of the deadliest gastrointestinal malignancies. Despite numerous…”
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MC4R Variant rs17782313 Associates With Increased Levels of DNAJC27, Ghrelin, and Visfatin and Correlates With Obesity and Hypertension in a Kuwaiti Cohort by Hammad, Maha M., Abu-Farha, Mohamed, Hebbar, Prashantha, Cherian, Preethi, Al Khairi, Irina, Melhem, Motasem, Alkayal, Fadi, Alsmadi, Osama, Thanaraj, Thangavel Alphonse, Al-Mulla, Fahd, Abubaker, Jehad

“…Melanocortin 4 receptor (MC4R), a notable component of the melanocortin system, regulates appetite, body weight, and energy homeostasis. Genome-wide…”
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