Search Results - "Hebach, Christina"

A straightforward approach towards cyclic peptides via ring-closing metathesis--scope and limitations by Kazmaier, Uli, Hebach, Christina, Watzke, Anja, Maier, Sabine, Mues, Heike, Huch, Volker

“…N- and C-terminal diallylated peptides are obtained by several approaches, such as peptide Claisen rearrangement, N- and O- allylation, and the Ugi reaction of…”
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Design, Synthesis, and In Vitro and In Vivo Evaluation of Cereblon Binding Bruton’s Tyrosine Kinase (BTK) Degrader CD79b Targeted Antibody–Drug Conjugates by Zhang, Alan, Seiss, Katherine, Laborde, Laurent, Palacio-Ramirez, Sebastian, Guthy, Daniel, Lanter, Mylene, Lorber, Julien, Vulpetti, Anna, Arista, Luca, Zoller, Thomas, Radimerski, Thomas, Thoma, Claudio, Hebach, Christina, Tschantz, William R., Karpov, Alexei, Hollingworth, Gregory J., D’Alessio, Joseph A., Ferretti, Stephane, Burger, Matthew T.

“…Antibody–drug conjugates (ADCs) are an established modality that allow for targeted delivery of a potent molecule, or payload, to a desired site of action…”
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Discovery of novel pyrrolidineoxy-substituted heteroaromatics as potent and selective PI3K delta inhibitors with improved physicochemical properties by Hoegenauer, Klemens, Soldermann, Nicolas, Hebach, Christina, Hollingworth, Gregory J., Lewis, Ian, von Matt, Anette, Smith, Alexander B., Wolf, Romain M., Wilcken, Rainer, Haasen, Dorothea, Burkhart, Christoph, Zécri, Frédéric

“…[Display omitted] In the recent years, PI3Kδ has emerged as a promising target for the treatment of B- and T-cell mediated inflammatory diseases. We present a…”
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Discovery and Pharmacological Characterization of Novel Quinazoline-Based PI3K Delta-Selective Inhibitors by Hoegenauer, Klemens, Soldermann, Nicolas, Stauffer, Frédéric, Furet, Pascal, Graveleau, Nadege, Smith, Alexander B, Hebach, Christina, Hollingworth, Gregory J, Lewis, Ian, Gutmann, Sascha, Rummel, Gabriele, Knapp, Mark, Wolf, Romain M, Blanz, Joachim, Feifel, Roland, Burkhart, Christoph, Zécri, Frédéric

“…Inhibition of the lipid kinase PI3Kδ is a promising principle to treat B and T cell driven inflammatory diseases. Using a scaffold…”
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Via Ugi reactions to conformationally fixed cyclic peptides by Hebach, Christina, Kazmaier, Uli

“…A simple approach to several cyclopeptidmimetics containing an N-alkylated amino acid was found via a multicomponent reaction followed by a ring-closing…”
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A straightforward approach towards glycoamino acids and glycopeptides via Pd-catalysed allylic alkylation by Krämer, Katja, Deska, Jan, Hebach, Christina, Kazmaier, Uli

“…Chelated enolates are versatile nucleophiles for palladium-catalysed allylic alkylations. Even with complex allylic substrates the reaction proceed without…”
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Carboxylate-stabilised sulfur ylides (thetin salts) in asymmetric epoxidation for the synthesis of glycidic acids. Mechanism and implications by Aggarwal, Varinder K, Hebach, Christina

“…The reaction of carboxylate-stabilised sulfur ylides (thetin salts) with aldehydes and ketones has been investigated. Using both achiral and chiral sulfur…”
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Readily Synthesized Chiral Sulfides as Reagents for Asymmetric Epoxidation by Badine, D. Michael, Hebach, Christina, Aggarwal, Varinder K.

“…Chiral oxathianes were designed, synthesized, and successfully used for asymmetric sulfur ylide mediated epoxidation. A considerable emphasis has been placed…”
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