Search Results - "Heavens, Robert"

Behavioral and Neurochemical Alterations in Mice Deficient in Anaplastic Lymphoma Kinase Suggest Therapeutic Potential for Psychiatric Indications by BILSLAND, James G, WHEELDON, Alan, WHITING, Paul, MCALLISTER, George, MUNOZ-SANJUAN, Ignacio, MEAD, Andrew, ZNAMENSKIY, Petr, ALMOND, Sarah, WATERS, Kerry A, THAKUR, Matthew, BEAUMONT, Vahri, BONNERT, Timothy P, HEAVENS, Robert

“…The receptor tyrosine kinase product of the anaplastic lymphoma kinase (ALK) gene has been implicated in oncogenesis as a product of several chromosomal…”
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Basal expression of bradykinin B1 receptor in the spinal cord in humans and rats by Ma, Qing-Ping, Heavens, Robert

“…The bradykinin B1 receptor has been considered as a receptor induced by tissue injury and inflammation mainly in the peripheral tissues. In the present study,…”
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Utility of Long-Term Cultured Human Hepatocytes as an in Vitro Model for Cytochrome P450 Induction by MENESES-LORENTE, Georgina, PATTISON, Christine, GUYOMARD, Claire, CHESNE, Christophe, HEAVENS, Robert, WATT, Alan P, SOHAL, Bindi

“…Cytochrome P450 (P450) induction may have considerable implications for drug therapy. Therefore, understanding the induction potential of a new chemical entity…”
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Characterization of a Novel Sphingosine 1-Phosphate Receptor, Edg-8 by Im, Dong-Soon, Heise, Christopher E., Ancellin, Nicolas, O'Dowd, Brian F., Shei, Gan-ju, Heavens, Robert P., Rigby, Michael R., Hla, Timothy, Mandala, Suzanne, McAllister, George, George, Susan R., Lynch, Kevin R.

“…Three G protein-coupled receptors (Edg-1, Edg-3, and Edg-5) for the lysolipid phosphoric acid mediator sphingosine 1-phosphate have been described by molecular…”
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θ , a Novel γ -Aminobutyric Acid Type A Receptor Subunit by Bonnert, Timothy P., McKernan, Ruth M., Farrar, Sophie, le Bourdellès, Béatrice, Heavens, Robert P., Smith, David W., Hewson, Louise, Rigby, Michael R., Dalip J. S. Sirinathsinghji, Brown, Nicola, Wafford, Keith A., Whiting, Paul J.

“…γ -Aminobutyric acid type A (GABA-A) receptors are a major mediator of inhibitory neurotransmission in the mammalian central nervous system, and the site of…”
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Molecular and Functional Diversity of the Expanding GABA-A Receptor Gene Family by WHITING, PAUL J., BONNERT, TIMOTHY P., MCKERNAN, RUTH M., FARRAR, SOPHIE, BOURDELLES, BEATRICE LE, HEAVENS, ROBERT P., SMITH, DAVID W., HEWSON, LOUISE, RIGBY, MICHAEL R., SIRINATHSINGHJI, DALIP J. S., THOMPSON, SALLY A., WAFFORD, KEITH A.

“…Fast inhibitory neurotransmission in the mammalian CNS is mediated primarily by the neurotransmitter γ‐aminobutyric acid (GABA), which, upon binding to its…”
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A genetically modified mouse model probing the selective action of ifenprodil at the N-methyl-d-aspartate type 2B receptor by Rosahl, Thomas W., Wingrove, Peter B., Hunt, Verity, Fradley, Rosa L., Lawrence, Jason M.K., Heavens, Robert P., Treacey, Patrick, Usala, Marcelo, Macaulay, Alison, Bonnert, Timothy P., Whiting, Paul J., Wafford, Keith A.

“…Selective antagonism of N-methyl-d-aspartate (NMDA) 2B subunit containing receptors has been suggested to have potential therapeutic application for multiple…”
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Characterisation of a sphingosine 1-phosphate-activated Ca2+ signalling pathway in human neuroblastoma cells by Villullas, Israel Ramos, Smith, Alison J., Heavens, Robert P., Simpson, Peter B.

“…Sphingosine 1‐phosphate (S1P) has assumed great importance within neuroscience research because of putative links between S1P‐sensitive Edg receptors and…”
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Cloning and Expression of a Novel Neuropeptide Y Receptor by Weinberg, David H., Sirinathsinghji, Dalip J.S., Tan, Carina P., Shiao, Lin-Lin, Morin, Nancy, Rigby, Michael R., Heavens, Robert H., Rapoport, Davida R., Bayne, Marvin L., Cascieri, Margaret A., Strader, Catherine D., Linemeyer, David L., MacNeil, Douglas J.

“…The neuropeptide Y family of peptides, which includes neuropeptide Y (NPY), peptide YY (PYY), and pancreatic polypeptide (PP), are found in the central and…”
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Distribution of 5-ht5A, 5-ht5B, 5-ht6 and 5-HT7 receptor mRNAs in the rat brain by KINSEY, Anna M, WAINWRIGHT, Anna, HEAVENS, Robert, SIRINATHSINGHJI, Dalip J. S, OLIVER, Kevin R

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Quantitative Comparison of Pretreatment Regimens Used to Sensitize In Situ Hybridization Using Oligonucleotide Probes on Paraffin-embedded Brain Tissue by Oliver, Kevin R, Heavens, Robert P, Sirinathsinghji, Dalip J. S

“…Paraffin embedding of tissue is generally perceived to dramatically reduce RNA detectability. As a consequence, in situ hybridization on paraffin-embedded…”
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Distribution of novel CGRP1 receptor and adrenomedullin receptor mRNAs in the rat central nervous system by OLIVER, K. R, WAINWRIGHT, A, HEAVENS, R. P, HILL, R. G, SIRINATHSINGHJI, D. J. S

“…Recent cloning studies have isolated receptors which confer specific responsiveness to calcitonin gene related peptide (CGRP) and the related peptide…”
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Retrieval of cellular mRNA in paraffin-embedded human brain using hydrated autoclaving by Oliver, Kevin R, Wainwright, Anna, Heavens, Robert P, Sirinathsinghji, Dalip J.S

“…The aims of this study were to determine the optimal pretreatment of paraffin-embedded human brain sections for in situ hybridization using oligonucleotide…”
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Striatal NMDAR2B mRNA expression after bilateral cortical and unilateral nigral deafferentation by Kayadjanian, N, Heavens, R P, Besson, M J, Sirinathsinghji, D J

“…We have studies by in situ hybridization histochemistry the regulation of NMDAR2B mRNA expression by dopaminergic (DA) and cortical glutamatergic afferent…”
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Neuronally Restricted RNA Splicing Regulates the Expression of a Novel GABAA Receptor Subunit Conferring Atypical Functional Properties by Whiting, Paul J, McAllister, George, Vassilatis, Demetrios, Bonnert, Timothy P, Heavens, Robert P, Smith, David W, Hewson, Louise, O'Donnell, Ruth, Rigby, Michael R, Sirinathsinghji, Dalip J. S, Marshall, George, Thompson, Sally A, Wafford, Keith A

“…We report the isolation and characterization of a cDNA encoding a novel member of the GABA receptor gene family, epsilon. This polypeptide is 506 amino acids…”
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A Receptor in Pituitary and Hypothalamus that Functions in Growth Hormone Release by Howard, Andrew D., Feighner, Scott D., Cully, Doris F., Arena, Joseph P., Liberator, Paul A., Rosenblum, Charles I., Hamelin, Michel, Hreniuk, Donna L., Palyha, Oksana C., Anderson, Jennifer, Paress, Philip S., Diaz, Carmen, Chou, Michael, Liu, Ken K., McKee, Karen Kulju, Pong, Sheng-Shung, Chaung, Lee-Yuh, Elbrecht, Alex, Dashkevicz, Mike, Heavens, Robert, Rigby, Mike, Dalip J. S. Sirinathsinghji, Dean, Dennis C., Melillo, David G., Patchett, Arthur A., Nargund, Ravi, Griffin, Patrick R., DeMartino, Julie A., Gupta, Sunil K., Schaeffer, James M., Smith, Roy G., Lex H. T. van der Ploeg

“…Small synthetic molecules termed growth hormone secretagogues (GHSs) act on the pituitary gland and the hypothalamus to stimulate and amplify pulsatile growth…”
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Regional and cellular localization of calcitonin gene-related peptide-receptor component protein mRNA in the guinea-pig central nervous system by Oliver, Kevin R, Wainwright, Anna, Kinsey, Anna M, Heavens, Robert P, Sirinathsinghji, Dalip J.S, Hill, Raymond G

“…Recent cloning studies have isolated proteins which confer responsiveness to calcitonin gene-related peptide (CGRP). In this study, we have determined the…”
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Molecular characterization of adult mouse subventricular zone progenitor cells during the onset of differentiation by Bonnert, Timothy P., Bilsland, James G., Guest, Paul C., Heavens, Robert, McLaren, Donna, Dale, Charlotte, Thakur, Matthew, McAllister, George, Munoz-Sanjuan, Ignacio

“…Adult mouse subventricular zone (SVZ) neural progenitor cells (NPCs) retain the capacity to generate multiple lineages in vitro and in vivo. Thus far, the…”
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β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity by Zheng, Hui, Jiang, Minghao, Trumbauer, Myrna E., Sirinathsinghji, Dalip J.S., Hopkins, Ruth, Smith, David W., Heavens, Robert P., Dawson, Gerard R., Boyce, Susan, Conner, Michael W., Stevens, Karla A., Slunt, Hilda H., Sisodia, Sangram S., Chen, Howard Y., Van der Ploeg, Lex H.T.

“…In several pedigrees of early onset familial Alzheimer's disease (FAD), point mutations in the β-amyloid precursor protein (APP) gene are genetically linked to…”
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Neuronally Restricted RNA Splicing Regulates the Expression of a Novel GABA A Receptor Subunit Conferring Atypical Functional Properties by Whiting, Paul J., McAllister, George, Vassilatis, Demetrios, Bonnert, Timothy P., Heavens, Robert P., Smith, David W., Hewson, Louise, O’Donnell, Ruth, Rigby, Michael R., Sirinathsinghji, Dalip J. S., Marshall, George, Thompson, Sally A., Wafford, Keith A.

“…We report the isolation and characterization of a cDNA encoding a novel member of the GABA receptor gene family, ε. This polypeptide is 506 amino acids in…”
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