Search Results - "Heaton, William L"

shRNA library screening identifies nucleocytoplasmic transport as a mediator of BCR-ABL1 kinase-independent resistance by Khorashad, Jamshid S., Eiring, Anna M., Mason, Clinton C., Gantz, Kevin C., Bowler, Amber D., Redwine, Hannah M., Yu, Fan, Kraft, Ira L., Pomicter, Anthony D., Reynolds, Kimberly R., Iovino, Anthony J., Zabriskie, Matthew S., Heaton, William L., Tantravahi, Srinivas K., Kauffman, Michael, Shacham, Sharon, Chenchik, Alex, Bonneau, Kyle, Ullman, Katharine S., O'Hare, Thomas, Deininger, Michael W.

“…The mechanisms underlying tyrosine kinase inhibitor (TKI) resistance in chronic myeloid leukemia (CML) patients lacking explanatory BCR-ABL1 kinase domain…”
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Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)-Resistant CML Lines While Circumventing Pharmacokinetic Liabilities by Ali, Ahmed M., Gómez-Biagi, Rodolfo F., Rosa, David A., Lai, Ping-Shan, Heaton, William L., Park, Ji Sung, Eiring, Anna M., Vellore, Nadeem A., de Araujo, Elvin D., Ball, Dan P., Shouksmith, Andrew E., Patel, Ami B., Deininger, Michael W., O'Hare, Thomas, Gunning, Patrick T.

“…Pharmacologic blockade of the activation of signal transducer and activator of transcription 3 (STAT3) in tyrosine kinase inhibitor (TKI)‐resistant chronic…”
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BCR-ABL1 Compound Mutations Combining Key Kinase Domain Positions Confer Clinical Resistance to Ponatinib in Ph Chromosome-Positive Leukemia by Zabriskie, Matthew S., Eide, Christopher A., Tantravahi, Srinivas K., Vellore, Nadeem A., Estrada, Johanna, Nicolini, Franck E., Khoury, Hanna J., Larson, Richard A., Konopleva, Marina, Cortes, Jorge E., Kantarjian, Hagop, Jabbour, Elias J., Kornblau, Steven M., Lipton, Jeffrey H., Rea, Delphine, Stenke, Leif, Barbany, Gisela, Lange, Thoralf, Hernández-Boluda, Juan-Carlos, Ossenkoppele, Gert J., Press, Richard D., Chuah, Charles, Goldberg, Stuart L., Wetzler, Meir, Mahon, Francois-Xavier, Etienne, Gabriel, Baccarani, Michele, Soverini, Simona, Rosti, Gianantonio, Rousselot, Philippe, Friedman, Ran, Deininger, Marie, Reynolds, Kimberly R., Heaton, William L., Eiring, Anna M., Pomicter, Anthony D., Khorashad, Jamshid S., Kelley, Todd W., Baron, Riccardo, Druker, Brian J., Deininger, Michael W., O’Hare, Thomas

“…Ponatinib is the only currently approved tyrosine kinase inhibitor (TKI) that suppresses all BCR-ABL1 single mutants in Philadelphia chromosome-positive (Ph+)…”
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Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion by Heaton, William L., Senina, Anna V., Pomicter, Anthony D., Salama, Mohamed E., Clair, Phillip M., Yan, Dongqing, Bell, Russell N., Gililland, Jeremy M., Prchal, Josef T., O’Hare, Thomas, Deininger, Michael W.

“…Tumor necrosis factor alpha (TNF) is increased in myelofibrosis (MF) and promotes survival of malignant over normal cells. The mechanisms altering TNF…”
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SIRT5 IS A DRUGGABLE METABOLIC VULNERABILITY IN ACUTE MYELOID LEUKEMIA by Yan, Dongqing, Franzini, Anca, Pomicter, Anthony D, Halverson, Brayden J, Antelope, Orlando, Mason, Clinton C, Ahmann, Jonathan M, Senina, Anna V, Vellore, Nadeem A, Jones, Courtney L, Zabriskie, Matthew S, Than, Hein, Xiao, Michael J, van Scoyk, Alexandria, Patel, Ami B, Clair, Phillip M, Heaton, William L, Owen, Shawn C, Andersen, Joshua L, Egbert, Christina M, Reisz, Julie A, D'Alessandro, Angelo, Cox, James E, Gantz, Kevin C, Redwine, Hannah M, Iyer, Siddharth M, Khorashad, Jamshid S, Rajabi, Nima, Olsen, Christian A, O'Hare, Thomas, Deininger, Michael W

“…We discovered that the survival and growth of many primary acute myeloid leukemia (AML) samples and cell lines, but not normal CD34+ cells, are dependent on…”
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Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer by Shouksmith, Andrew E, Shah, Fenil, Grimard, Michelle L, Gawel, Justyna M, Raouf, Yasir S, Geletu, Mulu, Berger-Becvar, Angelika, de Araujo, Elvin D, Luchman, H. Artee, Heaton, William L, Bakhshinyan, David, Adile, Ashley A, Venugopal, Chitra, O’Hare, Thomas, Deininger, Michael W, Singh, Sheila K, Konieczny, Stephen F, Weiss, Samuel, Fishel, Melissa L, Gunning, Patrick T

“…Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, incurable cancer with a 20% 1 year survival rate. While standard-of-care therapy can prolong life in…”
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Nuclear-Cytoplasmic Transport Is a Therapeutic Target in Myelofibrosis by Yan, Dongqing, Pomicter, Anthony D, Tantravahi, Srinivas, Mason, Clinton C, Senina, Anna V, Ahmann, Jonathan M, Wang, Qiang, Than, Hein, Patel, Ami B, Heaton, William L, Eiring, Anna M, Clair, Phillip M, Gantz, Kevin C, Redwine, Hannah M, Swierczek, Sabina I, Halverson, Brayden J, Baloglu, Erkan, Shacham, Sharon, Khorashad, Jamshid S, Kelley, Todd W, Salama, Mohamed E, Miles, Rodney R, Boucher, Kenneth M, Prchal, Josef T, O'Hare, Thomas, Deininger, Michael W

“…Myelofibrosis is a hematopoietic stem cell neoplasm characterized by bone marrow reticulin fibrosis, extramedullary hematopoiesis, and frequent transformation…”
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Coordinated inhibition of nuclear export and Bcr-Abl1 selectively targets chronic myeloid leukemia stem cells by Than, Hein, Pomicter, Anthony D., Yan, Dongqing, Beaver, Larry P., Eiring, Anna M., Heaton, William L., Senina, Anna, Clair, Phillip M., Shacham, Sharon, Mason, Clinton C., Hare, Thomas O’, Deininger, Michael W.

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Femoral Heads from Total Hip Arthroplasty as a Source of Adult Hematopoietic Cells by Pomicter, Anthony D, Clair, Phillip M, Yan, Dongqing, Heaton, William L, Eiring, Anna M, Anderson, Michael B, Richards, Stephen M, Gililland, Jeremy, O'Hare, Thomas, Deininger, Michael W

“…Normal human bone marrow cells are critical for studies of hematopoiesis and as controls to assess toxicity. As cells from commercial vendors are expensive,…”
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Discovery and characterization of AZD9272 and AZD6538—Two novel mGluR5 negative allosteric modulators selected for clinical development by Raboisson, Patrick, Breitholtz-Emanuelsson, Anna, Dahllöf, Henrik, Edwards, Louise, Heaton, William L., Isaac, Methvin, Jarvie, Keith, Kers, Annika, Minidis, Alexander B.E., Nordmark, Anna, Sheehan, Susan M., Slassi, Abdelmalik, Ström, Peter, Terelius, Ylva, Wensbo, David, Wilson, Julie M., Xin, Tao, McLeod, Donald A.

“…AZD9272 and AZD6538 are two novel mGluR5 negative allosteric modulators selected for further clinical development. An initial high-throughput screening…”
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Inside Cover: Disarming an Electrophilic Warhead: Retaining Potency in Tyrosine Kinase Inhibitor (TKI)-Resistant CML Lines While Circumventing Pharmacokinetic Liabilities (ChemMedChem 8/2016) by Ali, Ahmed M., Gómez-Biagi, Rodolfo F., Rosa, David A., Lai, Ping-Shan, Heaton, William L., Park, Ji Sung, Eiring, Anna M., Vellore, Nadeem A., de Araujo, Elvin D., Ball, Dan P., Shouksmith, Andrew E., Patel, Ami B., Deininger, Michael W., O'Hare, Thomas, Gunning, Patrick T.

“…The inside cover picture shows the small molecule AM‐1‐124, an inhibitor of imatinib‐resistant chronic myeloid leukemia (CML) cells. Pharmacologic blockade of…”
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3H-Quinazolin-4-ones as a new calcilytic template for the potential treatment of osteoporosis by SHCHERBAKOVA, Irina, BALANDRIN, Manuel F, FOX, John, GHATAK, Anjan, HEATON, William L, CONKLIN, Rebecca L

“…Structure-activity relationship studies, focused on identification of the active pharmacophore fragments in a single high-throughput screening calcilytic hit,…”
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Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones by Shcherbakova, Irina, Huang, Guangfei, Geoffroy, Otto J., Nair, Satheesh K., Swierczek, Krzysztof, Balandrin, Manuel F., Fox, John, Heaton, William L., Conklin, Rebecca L.

“…Design, new synthesis, structure–activity relationship studies and calcium receptor antagonist (calcilytic) properties of novel 3H-pyrimidin-4-ones are…”
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Combined STAT3 and BCR-ABL1 inhibition induces synthetic lethality in therapy-resistant chronic myeloid leukemia by Eiring, A M, Page, B D G, Kraft, I L, Mason, C C, Vellore, N A, Resetca, D, Zabriskie, M S, Zhang, T Y, Khorashad, J S, Engar, A J, Reynolds, K R, Anderson, D J, Senina, A, Pomicter, A D, Arpin, C C, Ahmad, S, Heaton, W L, Tantravahi, S K, Todic, A, Colaguori, R, Moriggl, R, Wilson, D J, Baron, R, O'Hare, T, Gunning, P T, Deininger, M W

“…Mutations in the BCR-ABL1 kinase domain are an established mechanism of tyrosine kinase inhibitor (TKI) resistance in Philadelphia chromosome-positive…”
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Abstract LB109: A critical role for SIRT5 in acute myeloid leukemia metabolism by Yan, Dongqing, Franzini, Anca, Pomicter, Anthony D., Halverson, Brayden J., Antelope, Orlando, Mason, Clinton C., Ahmann, Jonathan M., Senina, Anna V., Jones, Courtney L. L., Zabriskie, Matthew S., Than, Hein, Xiao, Michael J., van Scoyk, Alexandria, Patel, Ami B., Heaton, William L. L., Owen, Shawn C., Andersen, Joshua L., Egbert, Christina M., Reisz, Julie A., D'Alessandro, Angelo, Cox, James E., Gantz, Kevin C., Redwine, Hannah M., Iyer, Siddharth M., Khorashad, Jamshid S., Rajabi, Nima, Olsen, Christian A., O'Hare, Thomas, Deininger, Michael W.

“…Standard of care for AML includes chemotherapy and stem cell transplant, with 5-year survival rates <30%. We sought to identify genes critical to AML cells,…”
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Stroma-Based Activation of pSTAT3Y705 Confers Resistance to FLT3 Inhibitors in FLT3 ITD-Positive AML by Patel, Ami, Pomicter, Anthony D., Eiring, Anna M., Hein, Than, Heaton, William L., O'Hare, Thomas, Deininger, Michael W.

“…Acute myeloid leukemia (AML) is an aggressive hematopoietic neoplasm that carries the worst prognosis among the hematologic malignancies. Up to 30% of AML…”
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TNFR2 Signaling Promotes Myeloproliferative Disease Progression: A Role for MAPK8? by Heaton, William L., Senina, Anna, Pomicter, Anthony D., Marvin, James, Prchal, Josef T., O'Hare, Thomas, Deininger, Michael W.

“…The majority of patients diagnosed with Philadelphia negative (Ph-) myeloproliferative neoplasms (MPNs) harbor somatic, gain-of-function mutations in JAK2,…”
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SIRT5 As a Therapeutic Target in Acute Myeloid Leukemia by Yan, Dongqing, Pomicter, Anthony D., Heaton, William L., Mason, Clint C., Ahmann, Jonathan, Senina, Anna, Franzini, Anca, Halverson, Brayden, Than, Hein, Clair, Phillip M., Khorashad, Jamshid S, O'Hare, Thomas, Deininger, Michael W.

“…Acute myeloid leukemia (AML) is an aggressive hematopoietic neoplasm with five-year overall survival rates <30% on standard of care therapy. Relapse is common…”
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Inhibition of Nucleocytoplasmic Export Enhances Selective Elimination of Leukemic Stem Cells in Chronic Myeloid Leukemia by Than, Hein, Pomicter, Anthony D., Mason, Clinton C., Eiring, Anna M., Heaton, William L., Yan, Dongqing, Senina, Anna, Clair, Phillip M., Holyoake, Tessa L., O'Hare, Thomas, Deininger, Michael W.

“…Chronic myeloid leukemia (CML) is a hematopoietic stem cell malignancy driven by BCR-ABL1 tyrosine kinase and effectively managed with tyrosine kinase…”
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Effect of a TNFα Blocker and Peginfa on Polycythemia Vera Clonal Hematopoiesis and Suppressed Normal Dormant Hematopoiesis by Swierczek, Sabina, Kim, Soo Jin, Salama, Mohamed E, Heaton, William L., Deininger, Michael W., Prchal, Josef T.

“…Polycythemia vera (PV) is a clonal disorder arising from a single stem cell while normal stem cells are present in the marrow but are suppressed by the PV…”
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