Search Results - "Heaton, P."

Development and Characterization of a High Density SNP Genotyping Assay for Cattle by Matukumalli, Lakshmi K, Lawley, Cynthia T, Schnabel, Robert D, Taylor, Jeremy F, Allan, Mark F, Heaton, Michael P, O'Connell, Jeff, Moore, Stephen S, Smith, Timothy P.L, Sonstegard, Tad S, Van Tassell, Curtis P

“…The success of genome-wide association (GWA) studies for the detection of sequence variation affecting complex traits in human has spurred interest in the use…”
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First-in-Man Clinical Trial of the Oral Pan-AKT Inhibitor MK-2206 in Patients With Advanced Solid Tumors by YAP, Timothy A, LI YAN, RIISNAES, Ruth, POPE, Lorna L, HEATON, Simon P, THOMAS, George, GARRETT, Michelle D, SULLIVAN, Daniel M, DE BONO, Johann S, TOLCHER, Anthony W, PATNAIK, Amita, FEAREN, Ivy, OLMOS, David, PAPADOPOULOS, Kyriakos, BAIRD, Richard D, DELGADO, Liliana, TAYLOR, Adekemi, LUPINACCI, Lisa

“…AKT signaling is frequently deregulated in human cancers. MK-2206 is a potent, oral allosteric inhibitor of all AKT isoforms with antitumor activity in…”
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Worldwide patterns of ancestry, divergence, and admixture in domesticated cattle by Decker, Jared E, McKay, Stephanie D, Rolf, Megan M, Kim, Jaewoo, Molina Alcalá, Antonio, Sonstegard, Tad S, Hanotte, Olivier, Götherström, Anders, Seabury, Christopher M, Praharani, Lisa, Babar, Masroor Ellahi, Correia de Almeida Regitano, Luciana, Yildiz, Mehmet Ali, Heaton, Michael P, Liu, Wan-Sheng, Lei, Chu-Zhao, Reecy, James M, Saif-Ur-Rehman, Muhammad, Schnabel, Robert D, Taylor, Jeremy F

“…The domestication and development of cattle has considerably impacted human societies, but the histories of cattle breeds and populations have been poorly…”
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Haplotype-resolved genomes provide insights into structural variation and gene content in Angus and Brahman cattle by Low, Wai Yee, Tearle, Rick, Liu, Ruijie, Koren, Sergey, Rhie, Arang, Bickhart, Derek M., Rosen, Benjamin D., Kronenberg, Zev N., Kingan, Sarah B., Tseng, Elizabeth, Thibaud-Nissen, Françoise, Martin, Fergal J., Billis, Konstantinos, Ghurye, Jay, Hastie, Alex R., Lee, Joyce, Pang, Andy W. C., Heaton, Michael P., Phillippy, Adam M., Hiendleder, Stefan, Smith, Timothy P. L., Williams, John L.

“…Inbred animals were historically chosen for genome analysis to circumvent assembly issues caused by haplotype variation but this resulted in a composite of the…”
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Genome Wide Survey of SNP Variation Reveals the Genetic Structure of Sheep Breeds by Kijas, James W, Townley, David, Dalrymple, Brian P, Heaton, Michael P, Maddox, Jillian F, McGrath, Annette, Wilson, Peter, Ingersoll, Roxann G, McCulloch, Russell, McWilliam, Sean, Tang, Dave, McEwan, John, Cockett, Noelle, Oddy, V. Hutton, Nicholas, Frank W, Raadsma, Herman

“…The genetic structure of sheep reflects their domestication and subsequent formation into discrete breeds. Understanding genetic structure is essential for…”
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Formal-informal musical learning, sex and musicians' personalities by Rose, D., Jones Bartoli, A., Heaton, P.

“…Research has suggested that differences in personality traits among western musicians, in comparison to the general population, may be related to gender. For…”
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Structural variant-based pangenome construction has low sensitivity to variability of haplotype-resolved bovine assemblies by Leonard, Alexander S., Crysnanto, Danang, Fang, Zih-Hua, Heaton, Michael P., Vander Ley, Brian L., Herrera, Carolina, Bollwein, Heinrich, Bickhart, Derek M., Kuhn, Kristen L., Smith, Timothy P. L., Rosen, Benjamin D., Pausch, Hubert

“…Advantages of pangenomes over linear reference assemblies for genome research have recently been established. However, potential effects of sequence platform…”
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Superficial x-ray in the treatment of basal and squamous cell carcinomas: A viable option in select patients by Cognetta, Armand B., MD, Howard, Brett M., BA, Heaton, Henry P., BA, Stoddard, Earl R., MD, Hong, Hyokyoung Grace, PhD, Green, W. Harris, MD

“…Background Effective nonsurgical modalities are limited in the treatment of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). Objective We sought…”
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Characterization of Ovine Nectin-4, a Novel Peste des Petits Ruminants Virus Receptor by Birch, Jamie, Juleff, Nicholas, Heaton, Michael P, Kalbfleisch, Ted, Kijas, James, Bailey, Dalan

“…OA  Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+…”
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Measuring the effects of alexithymia on perception of emotional vocalizations in autistic spectrum disorder and typical development by Heaton, P, Reichenbacher, L, Sauter, D, Allen, R, Scott, S, Hill, E

“…The results from recent studies suggest that alexithymia, a disorder characterized by impairments in understanding personal experiences of emotion, is…”
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Impact of Four Ovine TMEM154 Haplotypes on Ewes during Multiyear Lentivirus Exposure by Freking, Brad A, Murphy, Tom W, Chitko-McKown, Carol G, Workman, Aspen M, Heaton, Michael P

“…Polypeptide variation encoded by the ovine transmembrane protein 154 gene (TMEM154) is associated with susceptibility to ovine lentivirus, the causative agent…”
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A phase 1, single-dose study of fresolimumab, an anti-TGF-β antibody, in treatment-resistant primary focal segmental glomerulosclerosis by Trachtman, Howard, Fervenza, Fernando C., Gipson, Debbie S., Heering, Peter, Jayne, David R.W., Peters, Harm, Rota, Stefano, Remuzzi, Giuseppe, Rump, L. Christian, Sellin, Lorenz K., Heaton, Jeremy P.W., Streisand, James B., Hard, Marjie L., Ledbetter, Steven R., Vincenti, Flavio

“…Primary focal segmental glomerulosclerosis (FSGS) is a disease with poor prognosis and high unmet therapeutic need. Here, we evaluated the safety and…”
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Whole Slide Imaging Versus Microscopy for Primary Diagnosis in Surgical Pathology: A Multicenter Blinded Randomized Noninferiority Study of 1992 Cases (Pivotal Study) by Mukhopadhyay, Sanjay, Feldman, Michael D, Abels, Esther, Ashfaq, Raheela, Beltaifa, Senda, Cacciabeve, Nicolas G, Cathro, Helen P, Cheng, Liang, Cooper, Kumarasen, Dickey, Glenn E, Gill, Ryan M, Heaton, Robert P, Kerstens, René, Lindberg, Guy M, Malhotra, Reenu K, Mandell, James W, Manlucu, Ellen D, Mills, Anne M, Mills, Stacey E, Moskaluk, Christopher A, Nelis, Mischa, Patil, Deepa T, Przybycin, Christopher G, Reynolds, Jordan P, Rubin, Brian P, Saboorian, Mohammad H, Salicru, Mauricio, Samols, Mark A, Sturgis, Charles D, Turner, Kevin O, Wick, Mark R, Yoon, Ji Y, Zhao, Po, Taylor, Clive R

“…Most prior studies of primary diagnosis in surgical pathology using whole slide imaging (WSI) versus microscopy have focused on specific organ systems or…”
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Introgression and disruption of migration routes have shaped the genetic integrity of wildebeest populations by Liu, Xiaodong, Lin, Long, Sinding, Mikkel-Holger S., Bertola, Laura D., Hanghøj, Kristian, Quinn, Liam, Garcia-Erill, Genís, Rasmussen, Malthe Sebro, Schubert, Mikkel, Pečnerová, Patrícia, Balboa, Renzo F., Li, Zilong, Heaton, Michael P., Smith, Timothy P. L., Pinto, Rui Resende, Wang, Xi, Kuja, Josiah, Brüniche-Olsen, Anna, Meisner, Jonas, Santander, Cindy G., Ogutu, Joseph O., Masembe, Charles, da Fonseca, Rute R., Muwanika, Vincent, Siegismund, Hans R., Albrechtsen, Anders, Moltke, Ida, Heller, Rasmus

“…The blue wildebeest ( Connochaetes taurinus ) is a keystone species in savanna ecosystems from southern to eastern Africa, and is well known for its…”
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Using whole genome sequence to compare variant callers and breed differences of US sheep by Stegemiller, Morgan R, Redden, Reid R, Notter, David R, Taylor, Todd, Taylor, J Bret, Cockett, Noelle E, Heaton, Michael P, Kalbfleisch, Theodore S, Murdoch, Brenda M

“…As whole genome sequence (WGS) data sets have become abundant and widely available, so has the need for variant detection and scoring. The aim of this study…”
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SNPs for parentage testing and traceability in globally diverse breeds of sheep by Heaton, Michael P, Leymaster, Kreg A, Kalbfleisch, Theodore S, Kijas, James W, Clarke, Shannon M, McEwan, John, Maddox, Jillian F, Basnayake, Veronica, Petrik, Dustin T, Simpson, Barry, Smith, Timothy P L, Chitko-McKown, Carol G

“…DNA-based parentage determination accelerates genetic improvement in sheep by increasing pedigree accuracy. Single nucleotide polymorphism (SNP) markers can be…”
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Association of TLR2 haplotypes encoding Q650 with reduced susceptibility to ovine Johne’s disease in Turkish sheep by Yaman, Yalçın, Aymaz, Ramazan, Keleş, Murat, Bay, Veysel, Ün, Cemal, Heaton, Michael P.

“…Ovine Johne’s disease (OJD) is caused by Mycobacterium avium subsp. paratuberculosis (MAP) and carries a potential zoonotic risk for humans. Selective breeding…”
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Gaur genome reveals expansion of sperm odorant receptors in domesticated cattle by Low, Wai Yee, Rosen, Benjamin D, Ren, Yan, Bickhart, Derek M, To, Thu-Hien, Martin, Fergal J, Billis, Konstantinos, Sonstegard, Tad S, Sullivan, Shawn T, Hiendleder, Stefan, Williams, John L, Heaton, Michael P, Smith, Timothy P L

“…The gaur (Bos gaurus) is the largest extant wild bovine species, native to South and Southeast Asia, with unique traits, and is listed as vulnerable by the…”
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AZD1152, a Selective Inhibitor of Aurora B Kinase, Inhibits Human Tumor Xenograft Growth by Inducing Apoptosis by WILKINSON, Robert W, ODEDRA, Rajesh, BYTH, Kate F, BARRASS, Nigel C, MUNDT, Kirsten E, FOOTE, Kevin M, HERON, Nicola M, JUNG, Frederic H, MORTLOCK, Andrew A, BOYLE, F. Thomas, GREEN, Stephen, HEATON, Simon P, WEDGE, Stephen R, KEEN, Nicholas J, CRAFTER, Claire, FOSTER, John R, BRADY, Madeleine C, BIGLEY, Alison, BROWN, Elaine

“…Purpose: In the current study, we examined the in vivo effects of AZD1152, a novel and specific inhibitor of Aurora kinase activity (with selectivity for…”
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G109(P) Recognition of Bile Colour in Neonates by Abdelrhim, HAM, Heaton, P

“…Introduction Neonatal bilious vomiting is a surgical emergency until proved otherwise, and requires prompt investigation. Health workers who are unfamiliar…”
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