Search Results - "Heather HICKMAN"

CXCR3 Chemokine Receptor Enables Local CD8+ T Cell Migration for the Destruction of Virus-Infected Cells by Hickman, Heather D., Reynoso, Glennys V., Ngudiankama, Barbara F., Cush, Stephanie S., Gibbs, James, Bennink, Jack R., Yewdell, Jonathan W.

“…CD8+ T cells play a critical role in limiting peripheral virus replication, yet how they locate virus-infected cells within tissues is unknown. Here, we have…”
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Wild Mouse Gut Microbiota Promotes Host Fitness and Improves Disease Resistance by Rosshart, Stephan P., Vassallo, Brian G., Angeletti, Davide, Hutchinson, Diane S., Morgan, Andrew P., Takeda, Kazuyo, Hickman, Heather D., McCulloch, John A., Badger, Jonathan H., Ajami, Nadim J., Trinchieri, Giorgio, Pardo-Manuel de Villena, Fernando, Yewdell, Jonathan W., Rehermann, Barbara

“…Laboratory mice, while paramount for understanding basic biological phenomena, are limited in modeling complex diseases of humans and other free-living…”
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A vaccine sanctuary in the lymph node by Kalia, Anurag, Hickman, Heather D

“…B cell follicles in the lymph node protect vaccines to enhance immune responses…”
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Slowing blood flow to fight viral infection by Hickman, Heather D

“…T cells produce acetylcholine to dilate blood vessels and migrate into infected tissues Cytotoxic T lymphocytes are the assassins of the immune system,…”
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Viral infection and antiviral immunity in the oral cavity by Hickman, Heather D., Moutsopoulos, Niki M.

“…Individual tissues have distinct antiviral properties garnered through various mechanisms, including physical characteristics, tissue-resident immune cells and…”
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The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction by Collins, Nicholas, Han, Seong-Ji, Enamorado, Michel, Link, Verena M., Huang, Bonnie, Moseman, E. Ashley, Kishton, Rigel J., Shannon, John P., Dixit, Dhaval, Schwab, Susan R., Hickman, Heather D., Restifo, Nicholas P., McGavern, Dorian B., Schwartzberg, Pamela L., Belkaid, Yasmine

“…Mammals evolved in the face of fluctuating food availability. How the immune system adapts to transient nutritional stress remains poorly understood. Here, we…”
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T Cell Surveillance during Cutaneous Viral Infections by Pei, Luxin, Hickman, Heather D

“…The skin is a complex tissue that provides a strong physical barrier against invading pathogens. Despite this, many viruses can access the skin and…”
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Intravital mucosal imaging of CD8+ resident memory T cells shows tissue-autonomous recall responses that amplify secondary memory by Beura, Lalit K., Mitchell, Jason S., Thompson, Emily A., Schenkel, Jason M., Mohammed, Javed, Wijeyesinghe, Sathi, Fonseca, Raissa, Burbach, Brandon J., Hickman, Heather D., Vezys, Vaiva, Fife, Brian T., Masopust, David

“…CD8 + T cell immunosurveillance dynamics influence the outcome of intracellular infections and cancer. Here we used two-photon intravital microscopy to…”
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Defining B cell immunodominance to viruses by Angeletti, Davide, Gibbs, James S, Angel, Matthew, Kosik, Ivan, Hickman, Heather D, Frank, Gregory M, Das, Suman R, Wheatley, Adam K, Prabhakaran, Madhu, Leggat, David J, McDermott, Adrian B, Yewdell, Jonathan W

“…Antigenic epitopes differ in their immunogenicity. Yewdell and colleagues show that B cell and antibody responses to influenza A virus infection display…”
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Aberrant type 1 immunity drives susceptibility to mucosal fungal infections by Break, Timothy J, Oikonomou, Vasileios, Dutzan, Nicolas, Desai, Jigar V, Swidergall, Marc, Freiwald, Tilo, Chauss, Daniel, Harrison, Oliver J, Alejo, Julie, Williams, Drake W, Pittaluga, Stefania, Lee, Chyi-Chia R, Bouladoux, Nicolas, Swamydas, Muthulekha, Hoffman, Kevin W, Greenwell-Wild, Teresa, Bruno, Vincent M, Rosen, Lindsey B, Lwin, Wint, Renteria, Andy, Pontejo, Sergio M, Shannon, John P, Myles, Ian A, Olbrich, Peter, Ferré, Elise M N, Schmitt, Monica, Martin, Daniel, Barber, Daniel L, Solis, Norma V, Notarangelo, Luigi D, Serreze, David V, Matsumoto, Mitsuru, Hickman, Heather D, Murphy, Philip M, Anderson, Mark S, Lim, Jean K, Holland, Steven M, Filler, Scott G, Afzali, Behdad, Belkaid, Yasmine, Moutsopoulos, Niki M, Lionakis, Michail S

“…Human monogenic disorders have revealed the critical contribution of type 17 responses in mucosal fungal surveillance. We unexpectedly found that in certain…”
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Neuraminidase inhibition contributes to influenza A virus neutralization by anti-hemagglutinin stem antibodies by Kosik, Ivan, Angeletti, Davide, Gibbs, James S, Angel, Matthew, Takeda, Kazuyo, Kosikova, Martina, Nair, Vinod, Hickman, Heather D, Xie, Hang, Brooke, Christopher B, Yewdell, Jonathan W

“…Broadly neutralizing antibodies (Abs) that bind the influenza virus hemagglutinin (HA) stem may enable universal influenza vaccination. Here, we show that…”
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Imaging viral infection in vivo to gain unique perspectives on cellular antiviral immunity by Vrba, Sophia M., Hickman, Heather D.

“…The past decade has seen near continual global public health crises caused by emerging viral infections. Extraordinary increases in our knowledge of the…”
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Nuclear translation visualized by ribosome-bound nascent chain puromycylation by David, Alexandre, Dolan, Brian P, Hickman, Heather D, Knowlton, Jonathan J, Clavarino, Giovanna, Pierre, Philippe, Bennink, Jack R, Yewdell, Jonathan W

“…Whether protein translation occurs in the nucleus is contentious. To address this question, we developed the ribopuromycylation method (RPM), which visualizes…”
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Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche by Clever, David, Roychoudhuri, Rahul, Constantinides, Michael G., Askenase, Michael H., Sukumar, Madhusudhanan, Klebanoff, Christopher A., Eil, Robert L., Hickman, Heather D., Yu, Zhiya, Pan, Jenny H., Palmer, Douglas C., Phan, Anthony T., Goulding, John, Gattinoni, Luca, Goldrath, Ananda W., Belkaid, Yasmine, Restifo, Nicholas P.

“…Cancer cells must evade immune responses at distant sites to establish metastases. The lung is a frequent site for metastasis. We hypothesized that…”
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Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis by Desai, Pritesh, Janova, Hana, White, James P., Reynoso, Glennys V., Hickman, Heather D., Baldridge, Megan T., Urban, Joseph F., Stappenbeck, Thaddeus S., Thackray, Larissa B., Diamond, Michael S.

“…Although enteric helminth infections modulate immunity to mucosal pathogens, their effects on systemic microbes remain less established. Here, we observe…”
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Intravenous nanoparticle vaccination generates stem-like TCF1+ neoantigen-specific CD8+ T cells by Baharom, Faezzah, Ramirez-Valdez, Ramiro A., Tobin, Kennedy K. S., Yamane, Hidehiro, Dutertre, Charles-Antoine, Khalilnezhad, Ahad, Reynoso, Glennys V., Coble, Vincent L., Lynn, Geoffrey M., Mulè, Matthew P., Martins, Andrew J., Finnigan, John P., Zhang, Xiao Meng, Hamerman, Jessica A., Bhardwaj, Nina, Tsang, John S., Hickman, Heather D., Ginhoux, Florent, Ishizuka, Andrew S., Seder, Robert A.

“…Personalized cancer vaccines are a promising approach for inducing T cell immunity to tumor neoantigens. Using a self-assembling nanoparticle vaccine that…”
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Hemagglutinin Receptor Binding Avidity Drives Influenza A Virus Antigenic Drift by Hensley, Scott E, Das, Suman R, Bailey, Adam L, Schmidt, Loren M, Hickman, Heather D, Jayaraman, Akila, Viswanathan, Karthik, Raman, Rahul, Sasisekharan, Ram, Bennink, Jack R, Yewdell, Jonathan W

“…Rapid antigenic evolution in the influenza A virus hemagglutinin precludes effective vaccination with existing vaccines. To understand this phenomenon, we…”
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Generation and Protective Ability of Influenza Virus–Specific Antibody-Dependent Cellular Cytotoxicity in Humans Elicited by Vaccination, Natural Infection, and Experimental Challenge by Jegaskanda, Sinthujan, Luke, Catherine, Hickman, Heather D., Sangster, Mark Y., Wieland-Alter, Wendy F., McBride, Jacqueline M., Yewdell, Jon W., Wright, Peter F., Treanor, John, Rosenberger, Carrie M., Subbarao, Kanta

“…Background. Nonneutralizing antibodies (Abs) involved in antibody-dependent cellular cytotoxicity (ADCC) may provide some protection from influenza virus…”
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Innate immune and chemically triggered oxidative stress modifies translational fidelity by David, Alexandre, Goodenbour, Jeffrey M, Netzer, Nir, Boone, David, Dolan, Brian, Pan, Tao, Jones, Richard B, Yewdell, Jonathan W, Bennink, Jack R, Embry, Alan, Rosner, Marsha R, Gibbs, James S, Hickman, Heather D, Eves, Eva M, Berglund, Peter, Das, Suman, Dittmar, Kimberly A, Schneider, Jeffrey R

“…Translational fidelity, essential for protein and cell function, requires accurate transfer RNA (tRNA) aminoacylation. Purified aminoacyl-tRNA synthetases…”
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Antiviral Activities of Group I Innate Lymphoid Cells by Lujan, Ramon A., Vrba, Sophia M., Hickman, Heather D.

“…[Display omitted] •ILC1s are tissue-resident innate lymphocytes with diverse functions.•ILC1s are maintained in the tissue during homeostasis and…”
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