Search Results - "Heathcote, Dan"

Evaluation of a convenient method of assessing rodent visual function in safety pharmacology studies: Effects of sodium iodate on visual acuity and retinal morphology in albino and pigmented rats and mice by Redfern, William S., Storey, Sharon, Tse, Karen, Hussain, Qasim, Maung, Khine Phu, Valentin, Jean-Pierre, Ahmed, Gulshanara, Bigley, Alison, Heathcote, Dan, McKay, Jennifer S.

“…We have evaluated the ability of a semi-automated, optomotor reflex method to assess drug-induced visual dysfunction, in albino and pigmented rats and mice…”
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Abstract 3343: The pre-clinical in vitro and in vivo activity of AZD6738: A potent and selective inhibitor of ATR kinase by Guichard, Sylvie M., Brown, Elaine, Odedra, Rajesh, Hughes, Adina, Heathcote, Dan, Barnes, Jen, Lau, Alan, Powell, Steve, Jones, Clifford D., Nissink, Willem, Foote, Kevin M., Jewsbury, Philip J., Pass, Martin

“…Abstract AZD6738 is a potent and selective orally bioavailable kinase inhibitor of ataxia telangiectasia and rad3 related (ATR). Here we report the…”
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Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent by Foote, Kevin M, Nissink, J. Willem M, McGuire, Thomas, Turner, Paul, Guichard, Sylvie, Yates, James W. T, Lau, Alan, Blades, Kevin, Heathcote, Dan, Odedra, Rajesh, Wilkinson, Gary, Wilson, Zena, Wood, Christine M, Jewsbury, Philip J

“…The kinase ataxia telangiectasia mutated and rad3 related (ATR) is a key regulator of the DNA-damage response and the apical kinase which orchestrates the…”
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Characterisation of the gastrointestinal and bone marrow toxicities associated with Irinotecan treatment after a single intra peritoneal dose in the Han Wistar rat by Cronin, Anna, Barnes, Jen, Derbyshire, Nicola, Heathcote, Dan, Pedersen, John

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Bromodomain and extraterminal (BET) domain inhibitors induce a loss of intestinal stem cells and villous atrophy by Wagoner, Matt, Kelsal, Janet, Hattersley, Maureen, Hickling, Kevin, Pederson, John, Harris, Jayne, Keirstead, Natalie, Heathcote, Dan, Newham, Pete

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Benefits of mTOR kinase targeting in oncology: pre-clinical evidence with AZD8055 by Marshall, Gayle, Howard, Zoe, Dry, Jonathan, Fenton, Sarah, Heathcote, Dan, Gray, Neil, Keen, Heather, Logie, Armelle, Holt, Sarah, Smith, Paul, Guichard, Sylvie M

“…AZD8055 is a small-molecule inhibitor of mTOR (mammalian target of rapamycin) kinase activity. The present review highlights molecular and phenotypic…”
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Abstract 917: AZD2014, a dual mTORC1 and mTORC2 inhibitor is differentiated from allosteric inhibitors of mTORC1 in ER+ breast cancer by Guichard, Sylvie M., Howard, Zoe, Heathcote, Dan, Roth, Mark, Hughes, Gareth, Curwen, Jon, Yates, James, Logie, Armelle, Holt, Sarah, Chresta, Christine M., Davies, Barry R., Malagu, Karine, Hummersone, Marc, Pass, Sarah L., Green, Stephen, Pass, Martin

“…Abstract The mammalian target of rapamycin (mTOR) is a major sensor of nutrients and energy and is part of two multiprotein complexes mTORC1 and mTORC2. mTOR…”
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Abstract 1823: AZ20, a novel potent and selective inhibitor of ATR kinase with in vivo antitumour activity by Jacq, Xavier, Smith, Lisa, Brown, Elaine, Hughes, Adina, Odedra, Rajesh, Heathcote, Dan, Barnes, Jen, Powell, Steve, Maguire, Sharon, Pearson, Victoria, Boros, Joana, Caie, Peter, Thommes, Pia A., Nissink, Willem, Foote, Kevin, Jewsbury, Philip J., Guichard, Sylvie M.

“…Abstract The DNA damage response (DDR) comprises a range of mechanisms that ensure the integrity of the genome. As part of the DDR and in response to specific…”
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