Search Results - "Heath, V L"

Intrathymic Expression of Genes Involved in Organ Specific Autoimmune Disease by Heath, Victoria L, Moore, Nel C, Parnell, Sonia M, Mason, Don W

“…Insulin, thyroglobulin and myelin basic protein (MBP) are implicated as autoantigens in the autoimmune diseases, insulin-dependent diabetes mellitus (IDDM),…”
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Peptides derived from murine insulin are diabetogenic in both rats and mice, but the disease-inducing epitopes are different: evidence against a common environmental cross-reactivity in the pathogenicity of type 1 diabetes by HEATH, V. L, HUTCHINGS, P, FOWELL, D. J, COOKE, A, MASON, D. W

“…Peptides derived from murine insulin are diabetogenic in both rats and mice, but the disease-inducing epitopes are different: evidence against a common…”
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Checkpoints in the regulation of T helper 1 responses by Heath, V L, Kurata, H, Lee, H J, Arai, N, O'Garra, A

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TGF- beta 1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression by Heath, V L, Murphy, EE, Crain, C, Tomlinson, M G, O'Garra, A

“…TGF- beta plays an important role in immune regulation in vivo and affects T cell differentiation in vitro. Here we describe how TGF- beta modulates Th2…”
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Hph1p and Hph2p, Novel Components of Calcineurin-Mediated Stress Responses in Saccharomyces cerevisiae by Heath, Victoria L, Shaw, Sidney L, Roy, Sharmili, Cyert, Martha S

“…Classifications Services EC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Cutting edge: ectopic expression of the IL-12 receptor-beta 2 in developing and committed Th2 cells does not affect the production of IL-4 or induce the production of IFN-gamma by Heath, V L, Showe, L, Crain, C, Barrat, F J, Trinchieri, G, O'Garra, A

“…The IL-12 receptor-beta 2 (IL-12R beta 2) chain is expressed on Th1 cells and lost upon differentiation to the Th2 phenotype. This has been suggested as the…”
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1α,25-Dihydroxyvitamin D3 Has a Direct Effect on Naive CD4+ T Cells to Enhance the Development of Th2 Cells by Boonstra, André, Barrat, Franck J., Crain, Chad, Heath, Victoria L., Savelkoul, Huub F. J., O’Garra, Anne

“…1α,25-Dihydroxyvitamin D3 (vitD3) is an immunoregulatory hormone with beneficial effects on Th1 mediated autoimmune diseases. Although the inhibitory effects…”
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The Role of the Thymus in the Control of Autoimmunity by Heath, Victoria L., Saoudi, Abdelhadi, Seddon, Benedict P., Moore, Nel C., Fowell, Deborah J., Mason, Don W.

“…Self tolerance among T cells is believed to be maintained by two principal mechanisms: clonal deletion for self antigens expressed in the thymus and T cell…”
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Phosphatidylinositol 3,5-bisphosphate: metabolism and cellular functions by Michell, Robert H., Heath, Victoria L., Lemmon, Mark A., Dove, Stephen K.

“…Polyphosphoinositides (PPIn) are low-abundance membrane phospholipids that each bind to a distinctive set of effector proteins and, thereby, regulate a…”
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1 alpha ,25-Dihydroxyvitamin D3 Has a Direct Effect on Naive CD4 super(+) T Cells to Enhance the Development of Th2 Cells by Boonstra, A, Barrat, F J, Crain, C, Heath, V L, Savelkoul, HFJ, O'Garra, A

“…1 alpha ,25-Dihydroxyvitamin D3 (vitD3) is an immunoregulatory hormone with beneficial effects on Th1 mediated autoimmune diseases. Although the inhibitory…”
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TGF-beta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression by Heath, V L, Murphy, E E, Crain, C, Tomlinson, M G, O'Garra, A

“…TGF-beta plays an important role in immune regulation in vivo and affects T cell differentiation in vitro. Here we describe how TGF-beta modulates Th2…”
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SHIP Family Inositol Phosphatases Interact with and Negatively Regulate the Tec Tyrosine Kinase by Tomlinson, Michael G., Heath, Victoria L., Turck, Chris W., Watson, Steve P., Weiss, Arthur

“…The Tec family of protein-tyrosine kinases (PTKs), that includes Tec, Itk, Btk, Bmx, and Txk, plays an essential role in phospholipase Cγ (PLCγ) activation…”
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Ectopic Expression of the IL-12 Receptor- beta 2 in Developing and Committed Th2 Cells Does Not Affect the Production of IL-4 or Induce the Production of IFN- gamma by Heath, V L, Showe, L, Crain, C, Barrat, F J, Trinchieri, G, O'Garra, A

“…The IL-12 receptor- beta 2 (IL-12R beta 2) chain is expressed on Th1 cells and lost upon differentiation to the Th2 phenotype. This has been suggested as the…”
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1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells by Boonstra, A, Barrat, F J, Crain, C, Heath, V L, Savelkoul, H F, O'Garra, A

“…1alpha,25-Dihydroxyvitamin D3 (vitD3) is an immunoregulatory hormone with beneficial effects on Th1 mediated autoimmune diseases. Although the inhibitory…”
Get full text