Search Results - "Heath, Nikki"

Rapid isolation and enrichment of extracellular vesicle preparations using anion exchange chromatography by Heath, Nikki, Grant, Lois, De Oliveira, Taiana Maia, Rowlinson, Rachel, Osteikoetxea, Xabier, Dekker, Niek, Overman, Ross

“…Extracellular vesicles (EVs) have important roles in physiology, pathology, and more recently have been identified as efficient carriers of therapeutic…”
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Vinculin Regulates the Recruitment and Release of Core Focal Adhesion Proteins in a Force-Dependent Manner by Carisey, Alex, Tsang, Ricky, Greiner, Alexandra M., Nijenhuis, Nadja, Heath, Nikki, Nazgiewicz, Alicja, Kemkemer, Ralf, Derby, Brian, Spatz, Joachim, Ballestrem, Christoph

“…Cells sense the extracellular environment using adhesion receptors (integrins) linked to the intracellular actin cytoskeleton through a complex network of…”
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Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels by Novo, David, Heath, Nikki, Mitchell, Louise, Caligiuri, Giuseppina, MacFarlane, Amanda, Reijmer, Dide, Charlton, Laura, Knight, John, Calka, Monika, McGhee, Ewan, Dornier, Emmanuel, Sumpton, David, Mason, Susan, Echard, Arnaud, Klinkert, Kerstin, Secklehner, Judith, Kruiswijk, Flore, Vousden, Karen, Macpherson, Iain R., Blyth, Karen, Bailey, Peter, Yin, Huabing, Carlin, Leo M., Morton, Jennifer, Zanivan, Sara, Norman, Jim C.

“…Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling…”
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Extracellular vesicles from human pancreatic islets suppress human islet amyloid polypeptide amyloid formation by Ribeiro, Diana, Horvath, Istvan, Heath, Nikki, Hicks, Ryan, Forslöw, Anna, Wittung-Stafshede, Pernilla

“…Extracellular vesicles (EVs) are small vesicles released by cells to aid cell–cell communication and tissue homeostasis. Human islet amyloid polypeptide (IAPP)…”
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Human pancreatic islet-derived extracellular vesicles modulate insulin expression in 3D-differentiating iPSC clusters by Ribeiro, Diana, Andersson, Eva-Marie, Heath, Nikki, Persson-Kry, Anette, Collins, Richard, Hicks, Ryan, Dekker, Niek, Forslöw, Anna

“…It has been suggested that extracellular vesicles (EVs) can mediate crosstalk between hormones and metabolites within pancreatic tissue. However, the possible…”
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Human pancreatic islet-derived extracellular vesicles modulates insulin expression in 3D-differentiating iPS clusters by Ribeiro, Diana, Andersson, Eva-Marie, Heath, Nikki, Persson-kry, Anette, Collins, Richard, Hicks, Ryan, Dekker, Niek, Forslöw, Anna

“…It has been suggested that extracellular vesicles (EVs) can mediate crosstalk between hormones and metabolites within pancreatic tissue. However, the possible…”
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Endosomal escape enhancing compounds facilitate functional delivery of extracellular vesicle cargo by Heath, Nikki, Osteikoetxea, Xabier, de Oliveria, Taiana Mia, Lázaro-Ibáñez, Elisa, Shatnyeva, Olga, Schindler, Christina, Tigue, Natalie, Mayr, Lorenz M, Dekker, Niek, Overman, Ross, Davies, Rick

“…Extracellular vesicles (EVs) are desirable delivery vehicles for therapeutic cargoes. We aimed to load EVs with Cre recombinase protein and determine whether…”
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An investigation into the role of microvesicles in mutant p53 invasive gain-of-function by Heath, Nikki

“…p53 is a transcription factor with tumour suppressive attributes which is known to be mutated in over half of human cancers. As well as compromising the…”
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Platelet-Derived Growth Factor Maintains Stored Calcium Through a Nonclustering Orai1 Mechanism But Evokes Clustering If the Endoplasmic Reticulum Is Stressed by Store Depletion by McKeown, Lynn, Moss, Nicholas K, Turner, Paul, Li, Jing, Heath, Nikki, Burke, Dermot, OʼRegan, David, Gilthorpe, Mark S, Porter, Karen E, Beech, David J

“…RATIONALE:Calcium entry through Orai1 channels drives vascular smooth muscle cell migration and neointimal hyperplasia. The channels are activated by the…”
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PDGF maintains stored calcium through a non-clustering Orai1 mechanism but evokes clustering if the ER is stressed by store-depletion by McKeown, Lynn, Moss, Nicholas K, Turner, Paul, Li, Jing, Heath, Nikki, Burke, Dermot, O’Regan, David, Gilthorpe, Mark S, Porter, Karen E, Beech, David J

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Platelet-Derived Growth Factor Maintains Stored Calcium Through a Nonclustering Orail Mechanism But Evokes Clustering If the Endoplasmic Reticulum Is Stressed by Store Depletion by MCKEOWN, Lynn, MOSS, Nicholas K, TURNER, Paul, JING LI, HEATH, Nikki, BURKE, Dermot, O'REGAN, David, GILTHORPE, Mark S, PORTER, Karen E, BEECH, David J

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Designer RNA binding proteins for loading exogenous RNA into extracellular vesicles by Shatnyeva, Olga, Gunnarsson, Anders, Gordon, Euan, Lázaro-Ibáñez, Elisa, Kunalingam, Lavaniya, Heath, Nikki, Osteikoetxea, Xabier, Overman, Ross, Maresca, Marcello, Dekker, Niek

“…Background: Recently extracellular vesicles (EVs) have gained tremendous attention as a delivery vehicle for effective targeted drug delivery. RNA-based…”
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Comparative lipidomics platform reveals distinct lipid profiles in extracellular vesicles by Osteikoetxea, Xabier, Schick, Jan, Bachman, Martin, Sinclair, Ian, Heath, Nikki, Lázaro-Ibáñez, Elisa, Shatnyeva, Olga, Dekker, Niek, Michopoulos, Filippos, Rowlinson, Rachel, Overman, Ross

“…Background: Recently, extracellular vesicles (EVs) have been shown to play important roles in various physiological and pathological processes. One area that…”
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Biodistribution, safety and toxicity profile of engineered extracellular vesicles by Lázaro-Ibáñez, Elisa, Saleh, Amer, Mairesse, Maelle, Rose, Jonathan, Harris, Jayne, Henderson, Neil, Shatnyeva, Olga, Osteikoetxea, Xabier, Heath, Nikki, Overman, Ross, Edmunds, Nicholas, Dekker, Niek

“…Background: The potential use of extracellular vesicles (EVs) as therapeutic carriers has attracted much interest with positive results in preclinical studies…”
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