Search Results - "Heath, I."

The biology and rationale of targeting nectin-4 in urothelial carcinoma by Heath, Elisabeth I., Rosenberg, Jonathan E.

“…Bladder cancer is the tenth most common cancer type worldwide. Urothelial carcinoma is the most common type of bladder cancer and accounts for 90% of bladder…”
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Pivotal Trial of Enfortumab Vedotin in Urothelial Carcinoma After Platinum and Anti-Programmed Death 1/Programmed Death Ligand 1 Therapy by Rosenberg, Jonathan E, O'Donnell, Peter H, Balar, Arjun V, McGregor, Bradley A, Heath, Elisabeth I, Yu, Evan Y, Galsky, Matthew D, Hahn, Noah M, Gartner, Elaina M, Pinelli, Juan M, Liang, Shang-Ying, Melhem-Bertrandt, Amal, Petrylak, Daniel P

“…Locally advanced or metastatic urothelial carcinoma is an incurable disease with limited treatment options, especially for patients who were previously treated…”
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Inactivation of CDK12 Delineates a Distinct Immunogenic Class of Advanced Prostate Cancer by Wu, Yi-Mi, Cieślik, Marcin, Lonigro, Robert J., Vats, Pankaj, Reimers, Melissa A., Cao, Xuhong, Ning, Yu, Wang, Lisha, Kunju, Lakshmi P., de Sarkar, Navonil, Heath, Elisabeth I., Chou, Jonathan, Feng, Felix Y., Nelson, Peter S., de Bono, Johann S., Zou, Weiping, Montgomery, Bruce, Alva, Ajjai, Robinson, Dan R., Chinnaiyan, Arul M.

“…Using integrative genomic analysis of 360 metastatic castration-resistant prostate cancer (mCRPC) samples, we identified a novel subtype of prostate cancer…”
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The challenge of overdiagnosis begins with its definition by Carter, S M, Rogers, W, Heath, I, Degeling, C, Doust, J, Barratt, A

“…Overdiagnosis means different things to different people. S M Carter and colleagues argue that we should use a broad term such as too much medicine for…”
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A stabilized linear finite element method for anisotropic poroelastodynamics with application to cardiac perfusion by Thekkethil, Namshad, Rossi, Simone, Gao, Hao, Richardson, Scott I. Heath, Griffith, Boyce E., Luo, Xiaoyu

“…We propose a variational multiscale method stabilization of a linear finite element method for nonlinear poroelasticity. Our approach is suitable for the…”
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Cabazitaxel plus carboplatin for the treatment of men with metastatic castration-resistant prostate cancers: a randomised, open-label, phase 1–2 trial by Corn, Paul G, MD, Heath, Elisabeth I, Prof, Zurita, Amado, MD, Ramesh, Naveen, MS, Xiao, Lianchun, MS, Sei, Emi, PhD, Li-Ning-Tapia, Elsa, MD, Tu, Shi-Ming, Prof, Subudhi, Sumit K, MD, Wang, Jennifer, MD, Wang, Xuemei, MS, Efstathiou, Eleni, MD, Thompson, Timothy C, Prof, Troncoso, Patricia, Prof, Navin, Nicholas, PhD, Logothetis, Christopher J, Prof, Aparicio, Ana M, MD

“…SummaryBackgroundTaxane–platinum combinations have shown promising activity in metastatic castration-resistant prostate cancers in single-group clinical…”
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Pharmacological targeting of CXCL12/CXCR4 signaling in prostate cancer bone metastasis by Conley-LaComb, M Katie, Semaan, Louie, Singareddy, Rajareddy, Li, Yanfeng, Heath, Elisabeth I, Kim, Seongho, Cher, Michael L, Chinni, Sreenivasa R

“…The CXCL12/CXCR4 axis transactivates HER2 and promotes intraosseous tumor growth. To further explore the transactivation of HER2 by CXCL12, we investigated the…”
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Early-stage multi-cancer detection using an extracellular vesicle protein-based blood test by Hinestrosa, Juan Pablo, Kurzrock, Razelle, Lewis, Jean M., Schork, Nicholas J., Schroeder, Gregor, Kamat, Ashish M., Lowy, Andrew M., Eskander, Ramez N., Perrera, Orlando, Searson, David, Rastegar, Kiarash, Hughes, Jake R., Ortiz, Victor, Clark, Iryna, Balcer, Heath I., Arakelyan, Larry, Turner, Robert, Billings, Paul R., Adler, Mark J., Lippman, Scott M., Krishnan, Rajaram

“…Background Detecting cancer at early stages significantly increases patient survival rates. Because lethal solid tumors often produce few symptoms before…”
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Case Report: Early detection of pancreatic pre-cancer lesion in multimodal approach with exosome liquid biopsy by Dhani, Harmeet, Hinestrosa, Juan Pablo, Izaguirre-Carbonell, Jesus, Balcer, Heath I, Kurzrock, Razelle, Billings, Paul R

“…The detection of pancreatic ductal adenocarcinoma (PDAC) lesions at pre-cancerous or early-stages is critical to improving patient survival. We have developed…”
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Biomarker-driven drug repurposing on biologically similar cancers with DNA-repair deficiencies by Munj, Seeya Awadhut, Taz, Tasnimul Alam, Arslanturk, Suzan, Heath, Elisabeth I

“…Similar molecular and genetic aberrations among diseases can lead to the discovery of jointly important treatment options across biologically similar diseases…”
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The concept of prevention: a good idea gone astray? by Starfield, B, Hyde, J, Gérvas, J, Heath, I

“…Over time, the definition of prevention has expanded so that its meaning in the context of health services is now unclear. As risk factors are increasingly…”
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A poroelastic immersed finite element framework for modelling cardiac perfusion and fluid–structure interaction by Richardson, Scott I. Heath, Gao, Hao, Cox, Jennifer, Janiczek, Rob, Griffith, Boyce E., Berry, Colin, Luo, Xiaoyu

“…Modern approaches to modelling cardiac perfusion now commonly describe the myocardium using the framework of poroelasticity. Cardiac tissue can be described as…”
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A Phase I Study of Foretinib, a Multi-Targeted Inhibitor of c-Met and Vascular Endothelial Growth Factor Receptor 2 by EDER, Joseph Paul, SHAPIRO, Geoffrey I, MCCALLUM, Stewart, HEATH, Elisabeth I, BOERNER, Scott A, LORUSSO, Patricia M, APPLEMAN, Leonard J, ZHU, Andrew X, MILES, Dale, KEER, Harold, CANCILLA, Belinda, CHU, Felix, HITCHCOCK-BRYAN, Suzanne, SHERMAN, Laurie

“…Foretinib is an oral multikinase inhibitor targeting Met, RON, Axl, and vascular endothelial growth factor receptor. We conducted a phase I,…”
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A Phase II Trial of 17-Allylamino-17-Demethoxygeldanamycin in Patients with Hormone-Refractory Metastatic Prostate Cancer by HEATH, Elisabeth I, HILLMAN, David W, PILI, Roberto, CARDUCCI, Michael A, ERLICHMAN, Charles, LIU, Glenn, VAISHAMPAYAN, Ulka, SHIJIE SHENG, SARKAR, Fazlul, HARPER, Felicity, GASKINS, Melvin, PITOT, Henry C, TAN, Winston, IVY, S. Percy

“…Purpose: 17-Allylamino-17-demethoxygeldanamycin (17-AAG) is a benzoquinone ansamycin antibiotic with antiproliferative activity in several mouse xenograft…”
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Genomic correlates of clinical outcome in advanced prostate cancer by Abida, Wassim, Cyrta, Joanna, Heller, Glenn, Prandi, Davide, Armenia, Joshua, Coleman, Ilsa, Cieslik, Marcin, Benelli, Matteo, Robinson, Dan, Van Allen, Eliezer M., Sboner, Andrea, Fedrizzi, Tarcisio, Mosquera, Juan Miguel, Robinson, Brian D., De Sarkar, Navonil, Kunju, Lakshmi P., Tomlins, Scott, Wu, Yi Mi, Rodrigues, Daniel Nava, Loda, Massimo, Gopalan, Anuradha, Reuter, Victor E., Pritchard, Colin C., Mateo, Joaquin, Bianchini, Diletta, Miranda, Susana, Carreira, Suzanne, Rescigno, Pasquale, Filipenko, Julie, Vinson, Jacob, Montgomery, Robert B., Beltran, Himisha, Heath, Elisabeth I., Scher, Howard I., Kantoff, Philip W., Taplin, Mary-Ellen, Schultz, Nikolaus, deBono, Johann S., Demichelis, Francesca, Nelson, Peter S., Rubin, Mark A., Chinnaiyan, Arul M., Sawyers, Charles L.

“…Heterogeneity in the genomic landscape of metastatic prostate cancer has become apparent through several comprehensive profiling efforts, but little is known…”
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Phase I Study of Folate Conjugate EC145 (Vintafolide) in Patients With Refractory Solid Tumors by LORUSSO, Patricia M, EDELMAN, Martin J, LEAMON, Christopher P, MESSMANN, Richard A, SAUSVILLE, Edward A, BEVER, Susan L, FORMAN, Karen M, PILAT, Maryjo, QUINN, Mary F, JING LI, HEATH, Elisabeth I, MALBURG, Lisa M, KLEIN, Patrick J

“…EC145 (vintafolide), a conjugate of folic acid and the vinca alkaloid desacetylvinblastine hydrazide (DAVLBH), is a ligand for the folate receptor (FR), with…”
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Muscadine Grape Skin Extract (MPX) in Men with Biochemically Recurrent Prostate Cancer: A Randomized, Multicenter, Placebo-Controlled Clinical Trial by Paller, Channing J, Zhou, Xian C, Heath, Elisabeth I, Taplin, Mary-Ellen, Mayer, Tina, Stein, Mark N, Bubley, Glenn J, Pili, Roberto, Hudson, Tamaro, Kakarla, Radhika, Abbas, Muneer M, Anders, Nicole M, Dowling, Donna, King, Serina, Bruns, Ashley B, Wagner, William D, Drake, Charles G, Antonarakis, Emmanuel S, Eisenberger, Mario A, Denmeade, Samuel R, Rudek, Michelle A, Rosner, Gary L, Carducci, Michael A

“…MuscadinePlus (MPX), a commercial preparation of pulverized muscadine grape skin, was evaluated as a therapeutic option for men with biochemically recurrent…”
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DISCO App: study protocol for a randomized controlled trial to test the effectiveness of a patient intervention to reduce the financial burden of cancer in a diverse patient population by Hamel, Lauren M, Dougherty, David W, Kim, Seongho, Heath, Elisabeth I, Mabunda, Lorna, Tadesse, Eyouab, Hill, RaeAnn, Eggly, Susan

“…Background Financial toxicity, the material and psychological burden of the cost of treatment, affects 30-50% of people with cancer, even those with health…”
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Prostate Cancer-Specific Lysine 53 Acetylation of Cytochrome c Drives Metabolic Reprogramming and Protects from Apoptosis in Intact Cells by Morse, Paul T, Wan, Junmei, Arroum, Tasnim, Herroon, Mackenzie K, Kalpage, Hasini A, Bazylianska, Viktoriia, Lee, Icksoo, Heath, Elisabeth I, Podgorski, Izabela, Hüttemann, Maik

“…Cytochrome (Cyt ) is important for both mitochondrial respiration and apoptosis, both of which are altered in cancer cells that switch to Warburg metabolism…”
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Nuclear Export Inhibitor KPT-8602 Synergizes with PARP Inhibitors in Escalating Apoptosis in Castration Resistant Cancer Cells by Uddin, Md. Hafiz, Li, Yiwei, Khan, Husain Yar, Muqbil, Irfana, Aboukameel, Amro, Sexton, Rachel E., Reddy, Shriya, Landesman, Yosef, Kashyap, Trinayan, Azmi, Asfar S., Heath, Elisabeth I.

“…Aberrant nuclear protein transport, often observed in cancer, causes mislocalization-dependent inactivation of critical cellular proteins. Earlier we showed…”
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