Search Results - "Heath, Heidi"

mDKN-01, a Novel Anti-DKK1 mAb, Enhances Innate Immune Responses in the Tumor Microenvironment by Haas, Michael S, Kagey, Michael H, Heath, Heidi, Schuerpf, Franziska, Rottman, James B, Newman, Walter

“…Dickkopf-1 (DKK1), a secreted modulator of Wnt signaling, is overexpressed in many cancers, is often associated with worse clinical outcomes, and has been…”
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Validation of a DKK1 RNAscope chromogenic in situ hybridization assay for gastric and gastroesophageal junction adenocarcinoma tumors by Caldwell, Charles, Rottman, James B., Paces, Will, Bueche, Elizabeth, Reitsma, Sofia, Gibb, Joseph, Adisetiyo, Vitria, Haas, Michael S., Heath, Heidi, Newman, Walter, Baum, Jason, Gianani, Roberto, Kagey, Michael H.

“…Dickkopf-1 (DKK1) is a secreted modulator of Wnt signaling that is frequently overexpressed in tumors and associated with poor clinical outcomes. DKN-01 is a…”
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Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism by He, Changhao, Maniyar, Rachana R, Avraham, Yahel, Zappasodi, Roberta, Rusinova, Radda, Newman, Walter, Heath, Heidi, Wolchok, Jedd D, Dahan, Rony, Merghoub, Taha, Meyerson, Joel R

“…GITR is a TNF receptor, and its activation promotes immune responses and drives antitumor activity. The receptor is activated by the GITR ligand (GITRL), which…”
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Expression of monocyte chemoattractant protein-1 and interleukin-8 receptors on subsets of T cells: correlation with transendothelial chemotactic potential by Qin, S, LaRosa, G, Campbell, J J, Smith-Heath, H, Kassam, N, Shi, X, Zeng, L, Buthcher, E C, Mackay, C R

“…The differential expression of chemokine receptors may be an important mechanism for the regulation of T cell migration. To test this, we examined the…”
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Learning Targets: Helping Kindergartners Focus on Letter Names and Sounds by DeStefano, Heidi Heath

“…[...]I needed to find a way to focus their efforts and encourage them to take ownership of their learning. In professional development sessions, my school…”
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Supporting Struggling Readers: Using Vocabulary Cartoons During Transition Times by DeStefano, Heidi Heath

“…[...]struggling readers who have difficulty negotiating text do not benefit as much from the reciprocal relationship between vocabulary knowledge and reading…”
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Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism by He, Changhao, Maniyar, Rachana R., Avraham, Yahel, Zappasodi, Roberta, Rusinova, Radda, Newman, Walter, Heath, Heidi, Wolchok, Jedd D., Dahan, Rony, Merghoub, Taha, Meyerson, Joel

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Abstract 1710: DKN-01, a therapeutic DKK1 neutralizing antibody, has immune modulatory activity in nonclinical tumor models by Haas, Michael, Heath, Heidi, Wu, Yinyuan, Zhang, Xinjun, Sirard, Cynthia, He, Xi, Newman, Walter, Kagey, Michael

“…Abstract Wnt signaling is a fundamental pathway that is dysregulated in oncology. The Wnt signaling modulator DKK1 is expressed in a variety of tumor types and…”
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Abstract 2404: Mechanistic insight into anti-tumor activity of DKN-01, a therapeutic antibody with immune modulatory activity by Haas, Michael, Heath, Heidi, Schurpf-Huber, Franziska, Wu, Yinyuan, Zhang, Xinjun, He, Xi, Yang, Min, Newman, Walter, Kagey, Michael

“…Abstract Wnt signaling is a fundamental pathway that is dysregulated in oncology. The Wnt signaling modulator DKK1 is expressed in a variety of tumor types and…”
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Abstract 2402: GITR cancer immunotherapy: Epitope swapping of anti-GITR TRX518 to inform functional translatability from mouse to human by Zappasodi, Roberta, Heath, Heidi, Zhang, Yang, Haas, Michael, Yang, Min, Mirabelli, Christopher, Wolchok, Jedd D., Sirard, Cyndi, Newman, Walter, Merghoub, Taha

“…Abstract Introduction: At 52.5% identity in their extracellular domains (ECDs), mouse and human GITR (CD357) sequences are only modestly conserved. Thus…”
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Building bridges: Strengthening communities through LGBTQ+ inclusion and unity by Heath, Heidi Carrington

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Abstract ND02: CTX112 and CTX131: Next-generation CRISPR/Cas9-engineered allogeneic (allo) CAR T cells incorporating novel edits that increase potency and efficacy in the treatment of lymphoid and solid tumors by Terrett, Jonathan A., Kalaitzidis, Demetrios, Dequeant, Mary-Lee, Karnik, Sushant, Ghonime, Mohammed, Guo, Changan, Chain, Robert, Heath, Heidi, Jaishankar, Nivedita, Yuen, Rachel, Settipane, Davis, Padalia, Zinkal, Zakas, Lauren, Kuppuraju, Meghna, Tetteh, Paul, Massilamany, Chandirasegaran, McEwan, Brigid, Leary, Glenn, Dar, Henia, Ferulo, Daniel, Allen, Melanie, Tipton, Kimberley, Serwer, Laura, Nguyen, Thao, Butler-Gauthier, Melanie, Sripakdeevong, Parin, Nagar, Shashwat D., Tang, Yin, Chaudhari, Hemangi, Flanagan, Nicole, Huang, Elaine, Phuyal, Shashwant, Koch, Elizabeth, Dunn, Andrew, Sula, Erisa, Waldman, Jacob, Loaiza, Cristian, Zhang, Maria Lei, Thorstensen, Erin, Steiger, Keith, Schum, Katie, Urbaez, Kayla, Benton, Mark, Ma, Anna, Cohen, Sarah, Weaver, Annie, Finch, Christopher, Morrow, Phuong Khanh

“…Abstract Allo CAR T cells represent an “off-the-shelf” treatment option that addresses the unmet need for immediately available, potentially curative…”
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Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis by Zabel, B A, Agace, W W, Campbell, J J, Heath, H M, Parent, D, Roberts, A I, Ebert, E C, Kassam, N, Qin, S, Zovko, M, LaRosa, G J, Yang, L L, Soler, D, Butcher, E C, Ponath, P D, Parker, C M, Andrew, D P

“…TECK (thymus-expressed chemokine), a recently described CC chemokine expressed in thymus and small intestine, was found to mediate chemotaxis of human G…”
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Building bridges by Heath, Heidi Carrington

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Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody by Heath, H, Qin, S, Rao, P, Wu, L, LaRosa, G, Kassam, N, Ponath, P D, Mackay, C R

“…Chemokines bind and signal through G-protein coupled seven transmembrane receptors. Various chemokine receptors are expressed on leukocytes, and these may…”
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C-C Chemokine Receptor 4 Expression Defines a Major Subset of Circulating Nonintestinal Memory T Cells of Both Th1 and Th2 Potential by Andrew, David P, Ruffing, Nancy, Kim, Chang H, Miao, Wenyan, Heath, Heidi, Li, You, Murphy, Kristine, Campbell, James J, Butcher, Eugene C, Wu, Lijun

“…CCR4, a chemokine receptor for macrophage-derived chemokine (MDC) and thymus and activation-regulated chemokine (TARC), has been implicated as a preferential…”
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Interaction of chemokine receptor CCR5 with its ligands: multiple domains for HIV-1 gp120 binding and a single domain for chemokine binding by Wu, L, LaRosa, G, Kassam, N, Gordon, C J, Heath, H, Ruffing, N, Chen, H, Humblias, J, Samson, M, Parmentier, M, Moore, J P, Mackay, C R

“…CCR5 is a chemokine receptor expressed by T cells and macrophages, which also functions as the principal coreceptor for macrophage (M)-tropic strains of HIV-1…”
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