Search Results - "Heasley, LE"

Autocrine and paracrine signaling through neuropeptide receptors in human cancer by Heasley, L E

“…Autocrine and paracrine signaling leading to stimulation of tumor cell growth is a common theme in human cancers. In addition to polypeptide growth factors…”
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Akt/Protein Kinase B Up-regulates Bcl-2 Expression through cAMP-response Element-binding Protein by Pugazhenthi, Subbiah, Nesterova, Albina, Sable, Carol, Heidenreich, Kim A., Boxer, Linda M., Heasley, Lynn E., Reusch, Jane E.-B.

“…In our previous study we showed that insulin-like growth factor-I induces a cAMP-response element (CRE) site-containing Bcl-2 promoter through a novel…”
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Innovations in risk-stratification and treatment of Veterans with oropharynx cancer; roadmap of the 2019 Field Based Meeting by Sandulache, V.C., Lei, Y.L., Heasley, L.E., Chang, M., Amos, C.I., Sturgis, E.M., Graboyes, E., Chiao, E.Y., Rogus-Pulia, N., Lewis, J., Madabhushi, A., Frederick, M.J., Sabichi, A., Ittmann, M., Yarbrough, W.G., Chung, C.H., Ferrarotto, R., Mai, Weiyuan, Skinner, H.D., Duvvuri, U., Gerngross, P., Sikora, A.G.

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Restoration of Wnt-7a Expression Reverses Non-small Cell Lung Cancer Cellular Transformation through Frizzled-9-mediated Growth Inhibition and Promotion of Cell Differentiation by Winn, Robert A., Marek, Lindsay, Han, Sun-Young, Rodriguez, Karen, Rodriguez, Nicole, Hammond, Mandy, Van Scoyk, Michelle, Acosta, Henri, Mirus, Justin, Barry, Nicholas, Bren-Mattison, Yvette, Van Raay, Terence J., Nemenoff, Raphael A., Heasley, Lynn E.

“…The Wnt signaling pathway is critical in normal development, and mutation of specific components is frequently observed in carcinomas of diverse origins…”
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Peroxisome proliferator-activated receptor-gamma is a target of nonsteroidal anti-inflammatory drugs mediating cyclooxygenase-independent inhibition of lung cancer cell growth by Wick, Marilee, Hurteau, Greg, Dessev, Christina, Chan, Daniel, Geraci, Mark W, Winn, Robert A, Heasley, Lynn E, Nemenoff, Raphael A

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the growth of different cancer cell types, suggesting a broad role for their cyclooxygenase (COX) targets…”
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PTTG1 Levels Are Predictive of Saracatinib Sensitivity in Ovarian Cancer Cell Lines by Nakachi, I, Helfrich, BA, Spillman, MA, Mickler, EA, Olson, CJ, Rice, JL, Coldren, CD, Heasley, LE, Geraci, MW, Stearman, RS

“…Src kinase is recognized as a key target for molecular cancer therapy. However, methods to efficiently select patients responsive to Src inhibitors are…”
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Multiplicity of protein serine-threonine phosphatases in PC12 pheochromocytoma and FTO-2B hepatoma cells by Wadzinski, B E, Heasley, L E, Johnson, G L

“…Protein purification and molecular cloning have defined five classes of protein serine-threonine phosphatase catalytic subunits referred to as types 1, 2A, 2B…”
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gamma-Catenin expression is reduced or absent in a subset of human lung cancers and re-expression inhibits transformed cell growth by Winn, Robert A, Bremnes, Roy M, Bemis, Lynne, Franklin, Wilbur A, Miller, York E, Cool, Carlyne, Heasley, Lynn E

“…Lung cancer is a heterogeneous disease categorized into multiple subtypes of cancers which likely arise from distinct patterns of genetic alterations and…”
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Ablation of MEKK4 Kinase Activity Causes Neurulation and Skeletal Patterning Defects in the Mouse Embryo by Abell, Amy N., Rivera-Perez, Jaime A., Cuevas, Bruce D., Uhlik, Mark T., Sather, Susan, Johnson, Nancy L., Minton, Suzanne K., Lauder, Jean M., Winter-Vann, Ann M., Nakamura, Kazuhiro, Magnuson, Terry, Vaillancourt, Richard R., Heasley, Lynn E., Johnson, Gary L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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MAPK Mediation of Hypertonicity-stimulated Cyclooxygenase-2 Expression in Renal Medullary Collecting Duct Cells by Yang, Tianxin, Huang, Yuning, Heasley, Lynn E., Berl, Tomas, Schnermann, Jurgen B., Briggs, Josephine P.

“…We have previously shown that hypertonicity stimulates cyclooxygenase-2 (COX-2) expression in cultured medullary epithelial cells. The aims of the present…”
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c-Jun NH2-terminal Kinase Regulation of the Apoptotic Response of Small Cell Lung Cancer Cells to Ultraviolet Radiation by Butterfield, L, Storey, B, Maas, L, Heasley, L E

“…Exposure of cultured small cell lung cancer (SCLC) cells to UV radiation induces apoptosis. We observed that the UV sensitivity of a panel of SCLC lines and…”
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Differential Gene Regulation by Specific Gain-of-function JNK1 Proteins Expressed in Swiss 3T3 Fibroblasts by Han, Sun-Young, Kim, Soo-Hyun, Heasley, Lynn E.

“…The c-Jun N-terminal kinases (JNKs) are encoded by three genes that yield 10 isoforms through alternative mRNA splicing. The roles of each JNK isoform in the…”
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Isoforms of Jun Kinase Are Differentially Expressed and Activated in Human Monocyte/Macrophage (THP-1) Cells by Dreskin, Stephen C, Thomas, Gregory W, Dale, Sara N, Heasley, Lynn E

“…Ten isoforms of c-jun N-terminal kinase (JNK) have been described that arise by differential mRNA splicing of three genes. In that the relative expression and…”
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Akt negatively regulates the cJun N-terminal kinase pathway in PC12 cells by Levresse, Valerie, Butterfield, Laura, Zentrich, Eve, Heasley, Lynn E.

“…The protein serine/threonine kinase Akt is a target of phosphatidylinositol 3‐kinase that mediates many of the trophic actions of growth factors on cells. In…”
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Multiple signaling conduits regulate global differentiation-specific gene expression in PC12 cells by Marek, Lindsay, Levresse, Valerie, Amura, Claudia, Zentrich, Eve, Putten, Vicki Van, Nemenoff, Raphael A., Heasley, Lynn E.

“…PC12 cells serve as a model for exploring nerve growth factor (NGF)‐stimulated signal pathways that mediate neural differentiation. We previously demonstrated…”
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Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C by NEMENOFF, R. A, WINITZ, S, NAN-XIN QIAN, VAN PUTTEN, V, JOHNSON, G. L, HEASLEY, L. E

“…Phospholipase A2 (PLA2) is the enzyme regulating the release of arachidonic acid in most cell types. A high molecular mass, 85-kDa soluble form of PLA2 (cPLA2)…”
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Signalling in stem cells: meeting on signal transduction determining the fate of stem cells by Heasley, Lynn E, Petersen, Bryon E

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Regulation of platinum-compound cytotoxicity by the c-Jun N-terminal kinase and c-Jun signaling pathway in small-cell lung cancer cells by Levresse, Valerie, Marek, Lindsay, Blumberg, Deborah, Heasley, Lynn E

“…Cytotoxic platinum compounds including cisplatin are standard cancer chemotherapeutics and are also activators of stress-signaling pathways. In this study, we…”
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Collaboration of JNKs and ERKs in Nerve Growth Factor Regulation of the Neurofilament Light Chain Promoter in PC12 Cells by Zentrich, Eve, Han, Sun-Young, Pessoa-Brandao, Luis, Butterfield, Laura, Heasley, Lynn E.

“…Nerve growth factor (NGF) induces transcription-dependent neural differentiation of PC12 cells, and the ERK family of MAPKs has been implicated as the dominant…”
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Inhibited Neurogenesis in JNK1-Deficient Embryonic Stem Cells by Amura, Claudia R., Marek, Lindsay, Winn, Robert A., Heasley, Lynn E.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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