Search Results - "Heasley, L E"

Mer or Axl receptor tyrosine kinase inhibition promotes apoptosis, blocks growth and enhances chemosensitivity of human non-small cell lung cancer by Linger, R M A, Cohen, R A, Cummings, C T, Sather, S, Migdall-Wilson, J, Middleton, D H G, Lu, X, Barón, A E, Franklin, W A, Merrick, D T, Jedlicka, P, DeRyckere, D, Heasley, L E, Graham, D K

“…Non-small cell lung cancer (NSCLC) is a prevalent and devastating disease that claims more lives than breast, prostate, colon and pancreatic cancers combined…”
Get full text

A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop by Ware, K E, Hinz, T K, Kleczko, E, Singleton, K R, Marek, L A, Helfrich, B A, Cummings, C T, Graham, D K, Astling, D, Tan, A-C, Heasley, L E

“…Despite initial and often dramatic responses of epidermal growth factor receptor (EGFR)-addicted lung tumors to the EGFR-specific tyrosine kinase inhibitors…”
Get full text

Adding to the mix: fibroblast growth factor and platelet-derived growth factor receptor pathways as targets in non-small cell lung cancer by Kono, S A, Heasley, L E, Doebele, R C, Camidge, D R

“…The treatment of advanced non small cell lung cancer (NSCLC) increasingly involves the use of molecularly targeted therapy with activity against either the…”
Get more information

Innovations in risk-stratification and treatment of Veterans with oropharynx cancer; roadmap of the 2019 Field Based Meeting by Sandulache, V.C., Lei, Y.L., Heasley, L.E., Chang, M., Amos, C.I., Sturgis, E.M., Graboyes, E., Chiao, E.Y., Rogus-Pulia, N., Lewis, J., Madabhushi, A., Frederick, M.J., Sabichi, A., Ittmann, M., Yarbrough, W.G., Chung, C.H., Ferrarotto, R., Mai, Weiyuan, Skinner, H.D., Duvvuri, U., Gerngross, P., Sikora, A.G.

Get full text

PTTG1 Levels Are Predictive of Saracatinib Sensitivity in Ovarian Cancer Cell Lines by Nakachi, I, Helfrich, BA, Spillman, MA, Mickler, EA, Olson, CJ, Rice, JL, Coldren, CD, Heasley, LE, Geraci, MW, Stearman, RS

“…Src kinase is recognized as a key target for molecular cancer therapy. However, methods to efficiently select patients responsive to Src inhibitors are…”
Get full text

Phosphorylation and activation of a high molecular weight form of phospholipase A2 by p42 microtubule-associated protein 2 kinase and protein kinase C by NEMENOFF, R. A, WINITZ, S, NAN-XIN QIAN, VAN PUTTEN, V, JOHNSON, G. L, HEASLEY, L. E

“…Phospholipase A2 (PLA2) is the enzyme regulating the release of arachidonic acid in most cell types. A high molecular mass, 85-kDa soluble form of PLA2 (cPLA2)…”
Get full text

Co-dependency of PKCδ and K-Ras: inverse association with cytotoxic drug sensitivity in KRAS mutant lung cancer by Ohm, A M, Tan, A-C, Heasley, L E, Reyland, M E

“…Recent studies suggest that the presence of a KRAS mutation may be insufficient for defining a clinically homogenous molecular group, as many KRAS mutant…”
Get full text

Isoforms of Jun Kinase Are Differentially Expressed and Activated in Human Monocyte/Macrophage (THP-1) Cells by Dreskin, Stephen C, Thomas, Gregory W, Dale, Sara N, Heasley, Lynn E

“…Ten isoforms of c-jun N-terminal kinase (JNK) have been described that arise by differential mRNA splicing of three genes. In that the relative expression and…”
Get full text

MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts by GUPTA, S. K, GALLEGO, C, JOHNSON, G. L, HEASLEY, L. E

“…Rat 1a fibroblasts transformed by the Gi2 oncogene, gip2, exhibit a constitutively elevated mitogen-activated protein (MAP) kinase activity that correlates…”
Get full text

Regulation of Protein Kinase C by Nerve Growth Factor, Epidermal Growth Factor, and Phorbol Esters in PC12 Pheochromocytoma Cells by Heasley, L E, Johnson, G L

“…We have used a permeabilized cell assay and a synthetic peptide substrate (KRTLRR) to specifically monitor the activity of protein kinase C in PC12 cells…”
Get full text

Multiple mitogen-activated protein kinases are regulated by hyperosmolality in mouse IMCD cells by Berl, T, Siriwardana, G, Ao, L, Butterfield, L M, Heasley, L E

“…Inner medullary collecting duct (IMCD) cells adapt to a hypertonic environment by synthesizing transporters that allow for accumulation of organic osmolytes…”
Get full text

Mitogen-Activated Protein Kinase Activation Resulting from Selective Oncogene Expression in NIH 3T3 and Rat 1a Cells by Gallego, Carme, Gupta, Sunil K., Heasley, Lynn E., Qian, Nan-Xin, Johnson, Gary L.

“…Mitogen-activated protein kinases (MAPKs) are serine/threonine kinases that are rapidly activated in response to a variety of growth factors in many cell…”
Get full text

Autocrine and paracrine signaling through neuropeptide receptors in human cancer by Heasley, L E

“…Autocrine and paracrine signaling leading to stimulation of tumor cell growth is a common theme in human cancers. In addition to polypeptide growth factors…”
Get full text

Mitogen-activated protein kinase activation is insufficient for growth factor receptor-mediated PC12 cell differentiation by Vaillancourt, Richard R., Heasley, Lynn E., Zamarripa, Jeffrey, Storey, Brooke, Valius, Mindaugas, Kazlauskas, Andrius, Johnson, Gary L.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Akt/Protein Kinase B Up-regulates Bcl-2 Expression through cAMP-response Element-binding Protein by Pugazhenthi, Subbiah, Nesterova, Albina, Sable, Carol, Heidenreich, Kim A., Boxer, Linda M., Heasley, Lynn E., Reusch, Jane E.-B.

“…In our previous study we showed that insulin-like growth factor-I induces a cAMP-response element (CRE) site-containing Bcl-2 promoter through a novel…”
Get full text

Synergistic effects of new chemopreventive agents and conventional cytotoxic agents against human lung cancer cell lines by SORIANO, A. F, HELFRICH, B, CHAN, D. C, HEASLEY, L. E, BUNN, P. A, CHOU, T.-C

“…Non-small cell lung cancer (NSCLC) cells have constitutively high expression of cytosolic phospholipase A2 (cPLA2) and cyclooxygenase (COX) 2. These NSCLC…”
Get full text

Inhibitory actions of cyclic adenosine monophosphate and pertussis toxin define two distinct epidermal growth factor–regulated pathways leading to activation of mitogen‐activated protein kinase in rat hepatocytes by Gines, P, Li, X, Brown, S E, Nakamura, T, Guzelian, P S, Heasley, L E, Schrier, R W, Nemenoff, R A

“…Increased intracellular cyclic adenosine monophosphate (cAMP) levels have been shown in some reports to inhibit and in other studies to stimulate growth…”
Get full text

Detection of nerve growth factor and epidermal growth factor-regulated protein kinases in PC12 cells with synthetic peptide substrates by Heasley, L E, Johnson, G L

“…Synthetic peptide substrates specific for cAMP-dependent protein kinase, protein kinase C, ribosomal S6 kinase, and Ca2+/calmodulin-dependent protein kinases…”
Get more information

Hormonal regulation of MAP kinase in cultured rat inner medullary collecting tubule cells by Heasley, L E, Senkfor, S I, Winitz, S, Strasheim, A, Teitelbaum, I, Berl, T

“…Mitogen-activated protein (MAP) kinase is a widely expressed protein serine/threonine kinase that serves as a convergence point for many signaling pathways…”
Get full text

A G protein mutant that inhibits thrombin and purinergic receptor activation of phospholipase A2 by GUPTA, S. K, DIEZ, E, HEASLEY, L. E, OSAWA, S, JOHNSON, G. L

“…The stimulation of phospholipase A2 by thrombin and type 2 (P2)-purinergic receptor agonists in Chinese hamster ovary cells is mediated by the G protein Gi. To…”
Get full text