Search Results - "Hearon, Christopher"

α‐Adrenergic regulation of blood flow in HFpEF: too much and not enough by Hearon, Christopher M.

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Reply from Christopher M. Hearon Jr by Hearon, Christopher M.

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Regulation of skeletal muscle blood flow during exercise in ageing humans by Hearon, Christopher M., Dinenno, Frank A.

“…The regulation of skeletal muscle blood flow and oxygen delivery to contracting skeletal muscle is complex and involves the mechanical effects of muscle…”
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The effect of lifelong exercise frequency on arterial stiffness by Shibata, Shigeki, Fujimoto, Naoki, Hastings, Jeffrey L., Carrick‐Ranson, Graeme, Bhella, Paul S., Hearon, Christopher M., Levine, Benjamin D.

“…Key points This study examined the effect of different ‘doses’ of lifelong (>25 years) exercise on arterial stiffening (a hallmark of vascular ageing) in older…”
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The effect of chronic habitual exercise on oxygen carrying capacity and blood compartment volumes in older adults by Wakeham, Denis J, Hearon, Jr, Christopher M, Levine, Benjamin D

“…Absolute total hemoglobin mass (tHbmass) and blood compartment volumes are often considered to be higher in endurance athletes compared with nonathletes, yet…”
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One-Year Committed Exercise Training Reverses Abnormal Left Ventricular Myocardial Stiffness in Patients With Stage B Heart Failure With Preserved Ejection Fraction by Hieda, Michinari, Sarma, Satyam, Hearon, Christopher M., MacNamara, James P., Dias, Katrin A., Samels, Mitchel, Palmer, Dean, Livingston, Sheryl, Morris, Margot, Levine, Benjamin D.

“…Individuals with left ventricular (LV) hypertrophy and elevated cardiac biomarkers in middle age are at increased risk for the development of heart failure…”
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The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice by Gano, Lindsey B, Donato, Anthony J, Pasha, Hamza M, Hearon, Jr, Christopher M, Sindler, Amy L, Seals, Douglas R

“…Reductions in arterial SIRT1 expression and activity with aging are linked to vascular endothelial dysfunction. We tested the hypothesis that the specific…”
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Increased Myocardial Stiffness in Patients With High-Risk Left Ventricular Hypertrophy: The Hallmark of Stage-B Heart Failure With Preserved Ejection Fraction by Hieda, Michinari, Sarma, Satyam, Hearon, Christopher M., Dias, Katrin A., Martinez, Jose, Samels, Mitchel, Everding, Braden, Palmer, Dean, Livingston, Sheryl, Morris, Margot, Howden, Erin, Levine, Benjamin D.

“…BACKGROUND:Individuals with left ventricular hypertrophy (LVH) and elevated cardiac biomarkers in middle age are at high risk for the development of heart…”
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Escape, lysis, and feedback: endothelial modulation of sympathetic vasoconstriction by Hearon, Christopher M, Dinenno, Frank A

“…•Myoendothelial projections are critical sites regulating sympathetic vasoconstriction.•EDH underlies myoendothelial feedback and metabolic vasodilation via…”
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Exercise intolerance in heart failure with preserved ejection fraction: Causes, consequences and the journey towards a cure by Bunsawat, Kanokwan, Nelson, Michael D., Hearon, Christopher M., Wray, D. Walter

“…Heart failure with preserved ejection fraction (HFpEF) accounts for over 50% of all heart failure cases nationwide and continues to rise in its prevalence. The…”
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Challenging the Hemodynamic Hypothesis in Heart Failure With Preserved Ejection Fraction: Is Exercise Capacity Limited by Elevated Pulmonary Capillary Wedge Pressure? by Sarma, Satyam, MacNamara, James P., Balmain, Bryce N., Hearon, Christopher M., Wakeham, Denis J., Tomlinson, Andrew R., Hynan, Linda S., Babb, Tony G., Levine, Benjamin D.

“…Exercise intolerance is a defining characteristic of heart failure with preserved ejection fraction (HFpEF). A marked rise in pulmonary capillary wedge…”
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The autophagy enhancer spermidine reverses arterial aging by LaRocca, Thomas J., Gioscia-Ryan, Rachel A., Hearon, Christopher M., Seals, Douglas R.

“…•We assessed the potential for spermidine supplementation to prevent/reverse arterial aging.•Spermidine reduced arterial stiffness and improved arterial…”
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Adrenergic control of skeletal muscle blood flow during chronic hypoxia in healthy males by Simpson, Lydia L, Hansen, Alexander B, Moralez, Gilbert, Amin, Sachin B, Hofstaetter, Florian, Gasho, Christopher, Stembridge, Mike, Dawkins, Tony G, Tymko, Michael M, Ainslie, Philip N, Lawley, Justin S, Hearon, Jr, Christopher M

“…Sympathetic transduction is reduced following chronic high-altitude (HA) exposure; however, vascular α-adrenergic signaling, the primary mechanism mediating…”
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Characterizing regional and global effects of epicardial adipose tissue on cardiac systolic and diastolic function by Hearon, Christopher M., Reddy, Shiva, Dias, Katrin A., Shankar, Aditi, MacNamara, James, Levine, Benjamin, Sarma, Satyam

“…Objective The aim of this retrospective study was to determine whether regional epicardial adipose tissue (EAT) exerts localized effects on adjacent myocardial…”
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Assessment of venous pressure by compression sonography of the internal jugular vein during 3 days of bed rest by Hearon, Christopher M., Peters, Kirsten, Dias, Katrin A., Macnamara, James P., Marshall, John E. T., Campain, Joseph, Martin, David, Marshal‐Goebel, Karina, Levine, Benjamin D.

“…Compression sonography has been proposed as a method for non‐invasive measurement of venous pressures during spaceflight, but initial reports of venous…”
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Global Reach 2018 Heightened α-Adrenergic Signaling Impairs Endothelial Function During Chronic Exposure to Hypobaric Hypoxia by Tymko, Michael M., Lawley, Justin S., Ainslie, Philip N., Hansen, Alexander B., Hofstaetter, Florian, Rainer, Simon, Amin, Sachin, Moralez, Gilbert, Gasho, Christopher, Vizcardo-Galindo, Gustavo, Bermudez, Daniela, Villafuerte, Francisco C., Hearon, Christopher M.

“…Chronic exposure to hypoxia is associated with elevated sympathetic nervous activity and reduced vascular function in lowlanders, and Andean highlanders…”
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Sympathetic Neural Control at Rest and During the Cold Pressor Test in Patients With Heart Failure With Preserved Ejection Fraction by Takeda, Ryosuke, Hissen, Sarah L, Akins, John D, Washio, Takuro, Hearon, Jr, Christopher M, MacNamara, James P, Sarma, Satyam, Levine, Benjamin D, Fadel, Paul J, Fu, Qi

“…We tested the hypothesis that patients with heart failure with preserved ejection fraction (HFpEF) would have greater muscle sympathetic nerve activity (MSNA)…”
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Mitochondrial quality control and age-associated arterial stiffening by LaRocca, Thomas J., Hearon, Christopher M., Henson, Grant D., Seals, Douglas R.

“…Stiffening of large elastic arteries with age increases the risk of cardiovascular diseases (CVD), but the underlying mechanisms are incompletely understood…”
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Augmentation of endothelium‐dependent vasodilatory signalling improves functional sympatholysis in contracting muscle of older adults by Hearon, Christopher M., Richards, Jennifer C., Racine, Mathew L., Luckasen, Gary J., Larson, Dennis G., Dinenno, Frank A.

“…Key points The ability of contracting skeletal muscle to attenuate sympathetic vasoconstriction (functional sympatholysis) is critical for maintaining blood…”
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Effect of Nightly Lower Body Negative Pressure on Choroid Engorgement in a Model of Spaceflight-Associated Neuro-ocular Syndrome: A Randomized Crossover Trial by Hearon, Jr, Christopher M, Dias, Katrin A, Babu, Gautam, Marshall, John E T, Leidner, James, Peters, Kirsten, Silva, Erika, MacNamara, James P, Campain, Joseph, Levine, Benjamin D

“…Astronauts returning from long-duration spaceflight experience ocular remodeling related to cephalad fluid shifts induced by microgravity. It is hypothesized…”
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