Search Results - "Hearn, A"

Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps by Park, Juwon, Wysocki, Robert W, Amoozgar, Zohreh, Maiorino, Laura, Fein, Miriam R, Jorns, Julie, Schott, Anne F, Kinugasa-Katayama, Yumi, Lee, Youngseok, Won, Nam Hee, Nakasone, Elizabeth S, Hearn, Stephen A, Küttner, Victoria, Qiu, Jing, Almeida, Ana S, Perurena, Naiara, Kessenbrock, Kai, Goldberg, Michael S, Egeblad, Mikala

“…Neutrophils, the most abundant type of leukocytes in blood, can form neutrophil extracellular traps (NETs). These are pathogen-trapping structures generated by…”
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Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer by Öhlund, Daniel, Handly-Santana, Abram, Biffi, Giulia, Elyada, Ela, Almeida, Ana S, Ponz-Sarvise, Mariano, Corbo, Vincenzo, Oni, Tobiloba E, Hearn, Stephen A, Lee, Eun Jung, Chio, Iok In Christine, Hwang, Chang-Il, Tiriac, Hervé, Baker, Lindsey A, Engle, Dannielle D, Feig, Christine, Kultti, Anne, Egeblad, Mikala, Fearon, Douglas T, Crawford, James M, Clevers, Hans, Park, Youngkyu, Tuveson, David A

“…Pancreatic stellate cells (PSCs) differentiate into cancer-associated fibroblasts (CAFs) that produce desmoplastic stroma, thereby modulating disease…”
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Selective release of microRNA species from normal and malignant mammary epithelial cells by Pigati, Lucy, Yaddanapudi, Sree C S, Iyengar, Ravi, Kim, Dong-Ja, Hearn, Steven A, Danforth, David, Hastings, Michelle L, Duelli, Dominik M

“…MicroRNAs (miRNAs) in body fluids are candidate diagnostics for a variety of conditions and diseases, including breast cancer. One premise for using…”
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PSPACE-completeness of sliding-block puzzles and other problems through the nondeterministic constraint logic model of computation by Hearn, Robert A., Demaine, Erik D.

“…We present a nondeterministic model of computation based on reversing edge directions in weighted directed graphs with minimum in-flow constraints on vertices…”
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Activity patterns and temporal avoidance by prey in response to Sunda clouded leopard predation risk by Ross, J., Hearn, A. J., Johnson, P. J., Macdonald, D. W.

“…Little is known about the activity patterns of Bornean ungulates, or the temporal interactions of these species with the Sunda clouded leopard Neofelis diardi…”
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Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells by Bardot, Evan S, Valdes, Victor J, Zhang, Jisheng, Perdigoto, Carolina N, Nicolis, Silvia, Hearn, Stephen A, Silva, Jose M, Ezhkova, Elena

“…While the Polycomb complex is known to regulate cell identity in ES cells, its role in controlling tissue‐specific stem cells is not well understood. Here we…”
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A Novel Role for High-Mobility Group A Proteins in Cellular Senescence and Heterochromatin Formation by Narita, Masashi, Narita, Masako, Krizhanovsky, Valery, Nuñez, Sabrina, Chicas, Agustin, Hearn, Stephen A., Myers, Michael P., Lowe, Scott W.

“…Cellular senescence is a stable state of proliferative arrest that provides a barrier to malignant transformation and contributes to the antitumor activity of…”
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Rb-Mediated Heterochromatin Formation and Silencing of E2F Target Genes during Cellular Senescence by Narita, Masashi, Nuñez, Sabrina, Heard, Edith, Narita, Masako, Lin, Athena W., Hearn, Stephen A., Spector, David L., Hannon, Gregory J., Lowe, Scott W.

“…Cellular senescence is an extremely stable form of cell cycle arrest that limits the proliferation of damaged cells and may act as a natural barrier to cancer…”
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Multi‐scale, multivariate community models improve designation of biodiversity hotspots in the Sunda Islands by Chiaverini, L., Macdonald, D. W., Bothwell, H. M., Hearn, A. J., Cheyne, S. M., Haidir, I., Hunter, L. T. B., Kaszta, Ż, Macdonald, E. A., Ross, J., Cushman, S. A.

“…Species occur in sympatric assemblages, bound together by ecological relationships and interspecific interactions. Borneo and Sumatra host some of the richest…”
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Mitochondrial Mislocalization Underlies Aβ42-Induced Neuronal Dysfunction in a Drosophila Model of Alzheimer's Disease by Iijima-Ando, Kanae, Hearn, Stephen A., Shenton, Christopher, Gatt, Anthony, Zhao, LiJuan, Iijima, Koichi

“…The amyloid-β 42 (Aβ42) is thought to play a central role in the pathogenesis of Alzheimer's disease (AD). However, the molecular mechanisms by which Aβ42…”
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Antagonistic Roles of Rac and Rho in Organizing the Germ Cell Microenvironment by Sarkar, Angshuman, Parikh, Nishita, Hearn, Stephen A., Fuller, Margaret T., Tazuke, Salli I., Schulz, Cordula

“…The capacity of stem cells to self renew and the ability of stem cell daughters to differentiate into highly specialized cells depend on external cues provided…”
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Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses by Blumberg, L J, Humphries, J E, Jones, S D, Pearce, L B, Holgate, R, Hearn, A, Cheung, J, Mahmood, A, Del Tito, B, Graydon, J S, Stolz, L E, Bitonti, A, Purohit, S, de Graaf, D, Kacena, K, Andersen, J T, Christianson, G J, Roopenian, D C, Hubbard, J J, Gandhi, A K, Lasseter, K, Pyzik, M, Blumberg, R S

“…The neonatal crystallizable fragment receptor (FcRn) functions as an intracellular protection receptor for immunoglobulin G (IgG). Recently, several clinical…”
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Overexpression of Neprilysin Reduces Alzheimer Amyloid-β42 (Aβ42)-induced Neuron Loss and Intraneuronal Aβ42 Deposits but Causes a Reduction in cAMP-responsive Element-binding Protein-mediated Transcription, Age-dependent Axon Pathology, and Premature Death in Drosophila by Iijima-Ando, Kanae, Hearn, Stephen A., Granger, Linda, Shenton, Christopher, Gatt, Anthony, Chiang, Hsueh-Cheng, Hakker, Inessa, Zhong, Yi, Iijima, Koichi

“…The amyloid-β42 (Aβ42) peptide has been suggested to play a causative role in Alzheimer disease (AD). Neprilysin (NEP) is one of the rate-limiting Aβ-degrading…”
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ChanFAD: A Functional Annotation Database for Ion Channels by Castro, Elizabeth V., Shepherd, John W., Guggenheim, Ryan S., Sengvoravong, Manimone, Hall, Bailey C., Chappell, McKenzie K., Hearn, Jessica A., Caraccio, Olivia N., Bissman, Cora, Lantow, Sydney, Buehner, Damian, Costlow, Harry R., Prather, David M., Zonza, Abigail M., Witt, Mallory, Zahratka, Jeffrey A.

“…Ion channels are integral membrane protein complexes critical for regulation of membrane potential, cell volume, and other signaling events. As complex…”
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Dissecting the Pathological Effects of Human Aβ40 and Aβ42 in Drosophila: A Potential Model for Alzheimer's Disease by Iijima, Koichi, Liu, Hsin-Ping, Chiang, Ann-Shyn, Hearn, Stephen A., Konsolaki, Mary, Zhong, Yi, Watson, James D.

“…Accumulation of amyloid-β (Aβ) peptides in the brain has been suggested to be the primary event in sequential progression of Alzheimer's disease (AD). Here, we…”
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Polymyositis in African HIV-infected subjects by Heckmann, J.M, Pillay, K, Hearn, A.P, Kenyon, C

“…Abstract Polymyositis in HIV-infected subjects, clinically and pathologically resemble polymyositis in non-HIV-infected subjects. We report 14 consecutive…”
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Chemical Analysis of Alaskan Iq’mik Smokeless Tobacco by Hearn, Bryan A., Renner, Caroline C., Ding, Yan S., Vaughan-Watson, Christina, Stanfill, Stephen B., Zhang, Liqin, Polzin, Gregory M., Ashley, David L., Watson, Clifford H.

“…Iq'mik, a form of smokeless tobacco (ST), is traditionally used by Cup'ik and Yup'ik Eskimo people of western Alaska. Iq'mik is sometimes incorrectly…”
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Review of evidence to guide primary health care policy and practice to prevent childhood obesity [Paper in Supplement: Evidence into Policy in Australian Primary Health Care] by Hearn, Lydia A, Miller, Margaret R, Campbell‐Pope, Renee

“…Objectives: To identify key barriers to effective engagement of primary health care (PHC) providers and families in promoting healthy weight among children…”
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Linking physiological and architectural models of cotton by Hanan, J.S, Hearn, A.B

“…Despite the strong influence of plant architecture on crop yield, most crop models either ignore it or deal with it in a very rudimentary way. This paper…”
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Hypothalamic-pituitary-adrenal axis function in patients with chronic depression by Watson, S, Gallagher, P, Del-Estal, D, Hearn, A, Ferrier, I N, Young, A H

“…Hypothalamic-pituitary-adrenal (HPA) axis function in patients with chronic depression has previously been shown to be normal when measured using the…”
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