Search Results - "Heard, Bryan"

Single intra-articular dexamethasone injection immediately post-surgery in a rabbit model mitigates early inflammatory responses and post-traumatic osteoarthritis-like alterations by Heard, Bryan J., Barton, Kristen I., Chung, May, Achari, Yamini, Shrive, Nigel G., Frank, Cyril B., Hart, David A.

“…ABSTRACT Despite surgical reconstruction of the anterior cruciate ligament, a significant number of patients will still develop post‐traumatic osteoarthritis…”
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Matrix metalloproteinase protein expression profiles cannot distinguish between normal and early osteoarthritic synovial fluid by Heard, Bryan J, Martin, Liam, Rattner, Jerome B, Frank, Cyril B, Hart, David A, Krawetz, Roman

“…Osteoarthritis (OA) and rheumatoid arthritis (RA) are diseases which result in the degeneration of the joint surface articular cartilage. Matrix…”
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Metabolic profiling of synovial fluid in a unilateral ovine model of anterior cruciate ligament reconstruction of the knee suggests biomarkers for early osteoarthritis by Mickiewicz, Beata, Heard, Bryan J., Chau, Johnny K., Chung, May, Hart, David A., Shrive, Nigel G., Frank, Cyril B., Vogel, Hans J.

“…ABSTRACT Joint injuries and subsequent osteoarthritis (OA) are the leading causes of chronic joint disease. In this work, we explore the possibility of…”
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Does surgical technique influence the burden of lung metastases in patients with pathologic long bone fractures? by Kendal, Joseph K, Heard, Bryan J, Abbott, Annalise G, Moorman, Scott W, Saini, Raghav, Puloski, Shannon K T, Monument, Michael J

“…The aims of this study are to (1) determine whether fixation of metastatic long bone fractures with an intramedullary nail (IMN) influences the incidence of…”
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Structural Consequences of a Partial Anterior Cruciate Ligament Injury on Remaining Joint Integrity: Evidence for Ligament and Bone Changes Over Time in an Ovine Model by Barton, Kristen I., Heard, Bryan J., Kroker, Andres, Sevick, Johnathan L., Raymond, Duncan A., Chung, May, Achari, Yamini, Martin, C. Ryan, Frank, Cyril B., Boyd, Steven K., Shrive, Nigel G., Hart, David A.

“…Background: Severe injury to the knee joint often results in accelerated posttraumatic osteoarthritis (PTOA). In an ovine knee injury model, altered kinematics…”
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Monocyte chemotactic protein‐1 inhibits chondrogenesis of synovial mesenchymal progenitor cells: An in vitro study by Harris, Quinn, Seto, Jonathan, O'Brien, Kate, Lee, Poh S., Kondo, Colleen, Heard, Bryan J., Hart, David A., Krawetz, Roman J.

“…Osteoarthritis (OA) is a multifactorial, often progressive, painful disease. OA often progresses with an apparent irreversible loss of articular cartilage,…”
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Postoperative fever in the time of COVID-19 by Bourget-Murray, Jonathan, Heard, Bryan J, Bansal, Rohit, Johnson, Andrew S, Powell, James

“…Postoperative fever is common following orthopedic trauma surgery. As the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection…”
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Use of pre‐clinical surgically induced models to understand biomechanical and biological consequences of PTOA development by Barton, Kristen I., Shekarforoush, Mehdi, Heard, Bryan J., Sevick, John L., Vakil, Paria, Atarod, Mohammad, Martin, Ryan, Achari, Yamini, Hart, David A., Frank, Cyril B., Shrive, Nigel G.

“…ABSTRACT Post‐traumatic osteoarthritis (PTOA) development is often observed following traumatic knee injuries involving key stabilising structures such as the…”
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Molecular Response of Rabbit Menisci to Surgically Induced Hemarthrosis and a Single Intra‐Articular Dexamethasone Treatment by Heard, Bryan J., Barton, Kristen I., Agbojo, Omokhowa M., Chung, May, Sevick, John L., Bader, Taylor J., Martin, C. Ryan, Shrive, Nigel G., Hart, David A.

“…ABSTRACT Anterior cruciate ligament reconstructive surgery can restore biomechanical stability, however, such surgery cannot reliably prevent the onset of…”
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Posttraumatic Osteoarthritis Development and Progression in an Ovine Model of Partial Anterior Cruciate Ligament Transection and Effect of Repeated Intra-articular Methylprednisolone Acetate Injections on Early Disease by Barton, Kristen I., Heard, Bryan J., Sevick, Johnathan L., Martin, C. Ryan, Shekarforoush, S.M. Mehdi, Chung, May, Achari, Yamini, Frank, Cyril B., Shrive, Nigel G., Hart, David A.

“…Background: Partial anterior cruciate ligament (p-ACL) ruptures are a common injury of athletes. However, few preclinical models have investigated the natural…”
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Three-dimensional in vivo kinematics and finite helical axis variables of the ovine stifle joint following partial anterior cruciate ligament transection by Barton, Kristen I., Shekarforoush, Mehdi, Heard, Bryan J., Sevick, Johnathan L., Martin, C. Ryan, Frank, Cyril B., Hart, David A., Shrive, Nigel G.

“…Partial anterior cruciate ligament (p-ACL) rupture is a common injury, but the impact of a p-ACL injury on in vivo joint kinematics has yet to be determined in…”
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A computational method to differentiate normal individuals, osteoarthritis and rheumatoid arthritis patients using serum biomarkers by Heard, Bryan J., Rosvold, Joshua M., Fritzler, Marvin J., El-Gabalawy, Hani, Wiley, J. Preston, Krawetz, Roman J.

“…The objective of this study was to develop a method for categorizing normal individuals (normal, n = 100) as well as patients with osteoarthritis (OA, n =…”
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The infrapatellar fat pad is affected by injury induced inflammation in the rabbit knee: use of dexamethasone to mitigate damage by Heard, Bryan J., Solbak, Nathan M., Chung, May, Achari, Yamini, Shrive, Nigel G., Frank, Cyril B., Hart, David A.

“…Objective and design The health of the infrapatellar fat pad (IFP) has been linked to pain, joint inflammation, and the onset of post-traumatic osteoarthritis…”
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Diet-induced obesity leads to pro-inflammatory alterations to the vitreous humour of the eye in a rat model by Collins, Kelsey H., Herzog, Walter, Reimer, Raylene A., Reno, Carol R., Heard, Bryan J., Hart, David A.

“…Objective and design The purpose of this study was to investigate if diet-induced obesity (DIO) and subsequent low-level systemic inflammation would result in…”
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Alterations in Joint Angular Velocity Following Traumatic Knee Injury in Ovine Models by Shekarforoush, Mehdi, Barton, Kristen I., Beveridge, Jillian E., Scott, Michael, Martin, C. Ryan, Muench, Gregory, Heard, Bryan J., Sevick, Johnathan L., Hart, David A., Frank, Cyril B., Shrive, Nigel G.

“…Little effort has been directed towards the consequence of an injury on joint angular velocity. We hypothesized that the magnitude of knee joint angular…”
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Tibiofemoral centroid velocity correlates more consistently with cartilage damage than does contact path length in two ovine models of stifle injury by Beveridge, Jillian E., Heard, Bryan J., Shrive, Nigel G., Frank, Cyril B.

“…ABSTRACT Anterior cruciate ligament (ACL) rupture and/or meniscal injury are known risk factors for post‐traumatic osteoarthritis. We tested the hypothesis…”
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Early joint tissue changes are highly correlated with a set of inflammatory and degradative synovial biomarkers after ACL autograft and its sham surgery in an ovine model by Heard, Bryan J., Achari, Yamini, Chung, May, Shrive, Nigel G., Frank, Cyril B.

“…While impossible in humans, the mechanisms of early cartilage, bone and meniscal damage can be quantified after anterior cruciate ligament (ACL) injury in…”
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Intraarticular and Systemic Inflammatory Profiles May Identify Patients with Osteoarthritis by HEARD, Bryan J, FRITZLER, Marvin J, WILEY, J. Preston, McALLISTER, Jenelle, MARTIN, Liam, EL-GABALAWY, Hani, HART, David A, FRANK, Cyril B, KRAWETZ, Roman

“…To determine whether cytokine/chemokine profiles from synovial fluid and sera discriminate mild/moderate osteoarthritis (OA) from normal and severe OA cohorts…”
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Alterations in Hoffa’s fat pad induced by an inflammatory response following idealized anterior cruciate ligament surgery by Solbak, Nathan M., Heard, Bryan J., Achari, Yamini, Chung, May, Shrive, Nigel G., Frank, Cyril B., Hart, David A.

“…Objective To determine whether inflammation following anterior cruciate ligament (ACL) reconstruction leads to long-term pathological changes in the…”
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Complete ACL/MCL deficiency induces variable degrees of instability in sheep with specific kinematic abnormalities correlating with degrees of early osteoarthritis by Frank, Cyril B., Beveridge, Jillian E., Huebner, Kyla D., Heard, Bryan J., Tapper, Janet E., O'Brien, Etienne J. O., Shrive, Nigel G.

“…People are not equally disabled by combined anterior cruciate ligament (ACL)/medial collateral ligament (MCL) injuries, nor do they all develop osteoarthritis…”
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