Search Results - "Healy, Zachary"

Transcriptional Profiling of CD8+ CMV-Specific T Cell Functional Subsets Obtained Using a Modified Method for Isolating High-Quality RNA From Fixed and Permeabilized Cells by Healy, Zachary R, Weinhold, Kent J, Murdoch, David M

“…Previous studies suggest that the presence of antigen-specific polyfunctional T cells is correlated with improved pathogen clearance, disease control, and…”
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Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation by Talalay, Paul, Fahey, Jed W, Healy, Zachary R, Wehage, Scott L, Benedict, Andrea L, Min, Christine, Dinkova-Kostova, Albena T

“…UV radiation (UVR) is a complete carcinogen that elicits a constellation of pathological events, including direct DNA damage, generation of reactive oxidants…”
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Heparin-based blood purification attenuates organ injury in baboons with Streptococcus pneumoniae pneumonia by Chen, Lingye, Kraft, Bryan D, Roggli, Victor L, Healy, Zachary R, Woods, Christopher W, Tsalik, Ephraim L, Ginsburg, Geoffrey S, Murdoch, David M, Suliman, Hagir B, Piantadosi, Claude A, Welty-Wolf, Karen E

“…Bacterial pneumonia is a major cause of morbidity and mortality worldwide despite the use of antibiotics, and novel therapies are urgently needed. Building on…”
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Transcription factors NRF2 and HSF1 have opposing functions in autophagy by Dayalan Naidu, Sharadha, Dikovskaya, Dina, Gaurilcikaite, Egle, Knatko, Elena V., Healy, Zachary R., Mohan, Hema, Koh, Glenn, Laurell, Axel, Ball, Graeme, Olagnier, David, de la Vega, Laureano, Ganley, Ian G., Talalay, Paul, Dinkova-Kostova, Albena T.

“…Autophagy plays a critical role in the maintenance of cellular homeostasis by degrading proteins, lipids and organelles. Autophagy is activated in response to…”
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Selectin Ligand Expression Regulates the Initial Vascular Interactions of Colon Carcinoma Cells: THE ROLES OF CD44V AND ALTERNATIVE SIALOFUCOSYLATED SELECTIN LIGANDS by Napier, Susan L, Healy, Zachary R, Schnaar, Ronald L, Konstantopoulos, Konstantinos

“…Selectin-mediated binding of tumor cells to platelets, leukocytes, and vascular endothelium may regulate their hematogenous spread in the microvasculature. We…”
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OMIP‐036: Co‐inhibitory receptor (immune checkpoint) expression analysis in human T cell subsets by Healy, Zachary R., Murdoch, David M.

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Inactivation of Tautomerase Activity of Macrophage Migration Inhibitory Factor by Sulforaphane: a Potential Biomarker for Anti-inflammatory Intervention by HEALY, Zachary R, HUA LIU, DAVID HOLTZCLAW, W, TALALAY, Paul

“…Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine with keto-enol tautomerase activity, rises rapidly in response to inflammation and is…”
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Stimulation of phagocytosis by sulforaphane by Suganuma, Hiroyuki, Fahey, Jed W., Bryan, Kelley E., Healy, Zachary R., Talalay, Paul

“…► Sulforaphane stimulates the phagocytosis of RAW 264.7 macrophages under conditions of serum deprivation. ► This effect does not require Nrf2-dependent…”
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A novel ultrasound approach in assessing IMAT in critically ill patients by Molinger, Jeroen, Whittle, John, Endeman, Henrik, MacLeod, David, Gupta, Rajan, Fudim, Marat, Haines, Krista L., Barkauskas, Christina, Healy, Zachary, Wischmeyer, Paul, Bakker, Jan

“…Background Muscle wasting is a common finding in critically ill patients associated with increased days of mechanical ventilation in the ICU. Muscle wasting…”
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Divergent Responses of Chondrocytes and Endothelial Cells to Shear Stress: Cross-Talk among COX-2, the Phase 2 Response, and Apoptosis by Healy, Zachary R., Lee, Norman H., Gao, Xiangqun, Goldring, Mary B., Talalay, Paul, Kensler, Thomas W., Konstantopoulos, Konstantinos

“…Fluid shear exerts anti-inflammatory and anti-apoptotic effects on endothelial cells by inducing the coordinated expression of phase 2 detoxifying and…”
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Prognostic significance of muscle fasciculations in critically Ill COVID-19 patients under mechanical ventilation by Molinger, Jeroen, Whittle, John, Cha, Susie, MacLeod, David, Fudim, Marat, Ulloa, Luis, Barkauskas, Christina, Healy, Zachary, Haines, Krista L., Gupta, Rajan T., Endeman, Henrik, van der Jagt, Mathieu, Gommers, Diederik, Bakker, Jan, Wischmeyer, Paul E.

“…Introduction The COVID-19 pandemic brought unprecedented challenges to healthcare systems worldwide, particularly the often challenging physical recovery from…”
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Nuclear respiratory factor-1 negatively regulates TGF-β1 and attenuates pulmonary fibrosis by Suliman, Hagir B., Healy, Zachary, Zobi, Fabio, Kraft, Bryan D., Welty-Wolf, Karen, Smith, Joshua, Barkauskas, Christina, Piantadosi, Claude A.

“…The preclinical model of bleomycin-induced lung fibrosis is useful to study mechanisms related to human pulmonary fibrosis. Using BLM in mice, we find low HO-1…”
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The relationship between semaphorin 3C and microvessel density in the progression of breast and oral neoplasia by Cole-Healy, Zachary, Vergani, Patricia, Hunter, Keith, Brown, Nicola J., Reed, Malcolm W.R., Staton, Carolyn A.

“…This study aimed to identify the expression of semaphorin 3C (SEMA3C) in the normal-metastatic spectrum of breast and oral cancers, and correlate expression…”
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Distraction test for simple mandibular angle fractures – a useful test to aid clinical decision making by Cole-Healy, Zachary, Sainuddin, Sajid

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Shear-induced Cyclooxygenase-2 via a JNK2/c-Jun-dependent Pathway Regulates Prostaglandin Receptor Expression in Chondrocytic Cells by Abulencia, James P., Gaspard, Renee, Healy, Zachary R., Gaarde, William A., Quackenbush, John, Konstantopoulos, Konstantinos

“…Using cDNA microarrays coupled with bioinformatics tools, we elucidated a signaling cascade regulating cyclooxygenase-2 (COX-2), a pivotal pro-inflammatory…”
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Pilot Randomized Controlled Trial of Omega-3 and Individual-Family Psychoeducational Psychotherapy for Children and Adolescents With Depression by Fristad, Mary A, Vesco, Anthony T, Young, Andrea S, Healy, K Zachary, Nader, Elias S, Gardner, William, Seidenfeld, Adina M, Wolfson, Hannah L, Arnold, L Eugene

“…The goal of this study is to evaluate feasibility and estimate effect sizes of omega-3 fatty acids (Ω3), individual-family psychoeducational psychotherapy…”
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110. Distraction Test for Simple Mandibular Angle Fractures – A Useful Test To Aid Clinical Decision Making by Cole-Healy, Zachary, Cole-Healy, Zachary, Sainuddin, Sajid

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Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors by Healy, Zachary R., Dinkova‐Kostova, Albena T., Wehage, Scott L., Thompson, Richard E., Fahey, Jed W., Talalay, Paul

“…Background: We describe highly reproducible methods for quantifying the erythema response of precisely selected areas (spots) of human skin to graded doses of…”
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A Randomized Controlled Trial of Individual Family Psychoeducational Psychotherapy and Omega-3 Fatty Acids in Youth with Subsyndromal Bipolar Disorder by Fristad, Mary A, Young, Andrea S, Vesco, Anthony T, Nader, Elias S, Healy, K Zachary, Gardner, William, Wolfson, Hannah L, Arnold, L Eugene

“…This pilot study evaluates efficacy of omega-3 fatty acid supplementation (Ω3), individual family psychoeducational psychotherapy (IF-PEP), and their…”
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122. Lingual Raynaud’s phenomenon! A differential for intermittent pain and discolouration of the tongue by Patel, Roshni, Patel, Roshni, Cole-Healy, Zachary, Khandavilli, Sunil

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