Search Results - "Healy, Jason P."

4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase by Han, Qiang, Pabba, Praveen K., Barbosa, Joseph, Mabon, Ross, Healy, Jason P., Gardyan, Michael W., Terranova, Kristen M., Brommage, Robert, Thompson, Andrea Y., Schmidt, James M., Wilson, Alan G.E., Xu, Xiaolian, Tarver, James E., Carson, Kenneth G.

“…A group of small molecule thienochromenes inhibitors of Notum Pectinacetylesterase are described. We developed SAR on three series based on carbon, oxygen and…”
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Lead optimization and structure-based design of potent and bioavailable deoxycytidine kinase inhibitors by Jessop, Theodore C., Tarver, James E., Carlsen, Marianne, Xu, Amy, Healy, Jason P., Heim-Riether, Alexander, Fu, Qinghong, Taylor, Jerry A., Augeri, David J., Shen, Min, Stouch, Terry R., Swanson, Ronald V., Tari, Leslie W., Hunter, Michael, Hoffman, Isaac, Keyes, Philip E., Yu, Xuan-Chuan, Miranda, Maricar, Liu, Qingyun, Swaffield, Jonathan C., David Kimball, S., Nouraldeen, Amr, Wilson, Alan G.E., Foushee, Ann Marie DiGeorge, Jhaver, Kanchan, Finch, Rick, Anderson, Steve, Oravecz, Tamas, Carson, Kenneth G.

“…A series of deoxycytidine kinase inhibitors was simultaneously optimized for potency and PK properties. A co-crystal structure then allowed merging this series…”
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5-Fluorocytosine derivatives as inhibitors of deoxycytidine kinase by Tarver, James E., Jessop, Theodore C., Carlsen, Marianne, Augeri, David J., Fu, Qinghong, Healy, Jason P., Heim-Riether, Alexander, Xu, Amy, Taylor, Jerry A., Shen, Min, Keyes, Philip E., David Kimball, S., Yu, Xuan-Chuan, Miranda, Maricar, Liu, Qingyun, Swaffield, Jonathan C., Nouraldeen, Amr, Wilson, Alan G.E., Finch, Rick, Jhaver, Kanchan, Foushee, Ann Marie DiGeorge, Anderson, Steve, Oravecz, Tamas, Carson, Kenneth G.

“…A series of potent piperidine-linked cytosine derivatives were prepared as inhibitors of deoxycytidine kinase (dCK). Compound 9h was discovered to be a potent…”
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