Search Results - "Healy, Connor"

Biological Cells as Therapeutic Delivery Vehicles by Bush, Lucas M., Healy, Connor P., Javdan, Shwan B., Emmons, Jonathan C., Deans, Tara L.

“…One of the significant challenges remaining in the field of drug delivery is insufficient targeting of diseased tissues or cells. While efforts to perform…”
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High-throughput enrichment and isolation of megakaryocyte progenitor cells from the mouse bone marrow by Bush, Lucas M., Healy, Connor P., Marvin, James E., Deans, Tara L.

“…Megakaryocytes are a rare population of cells that develop in the bone marrow and function to produce platelets that circulate throughout the body and form…”
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Lower frequencies of circulating suppressive regulatory T cells and higher frequencies of CD4+ naïve T cells at baseline are associated with severe immune-related adverse events in immune checkpoint inhibitor-treated melanoma by Kovacsovics-Bankowski, Magdalena, Sweere, Johanna M, Healy, Connor P, Sigal, Natalia, Cheng, Li-Chun, Chronister, William D, Evans, Shane A, Marsiglio, John, Gibson, Berit, Swami, Umang, Erickson-Wayman, Alyssa, McPherson, Jordan P, Derose, Yoko S, Eliason, Annaleah Larson, Medina, Carlos O, Srinivasan, Ramji, Spitzer, Matthew H, Nguyen, Ngan, Hyngstrom, John, Hu-Lieskovan, Siwen

“…BackgroundImmune-related adverse events (irAEs) are major barriers of clinical management and further development of immune checkpoint inhibitors (ICIs) for…”
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Measuring the Immeasurable: Refined Spatial Statistics and Morphological Analyses for Biology by Healy, Connor

“…Non-random spatial patterns in biological phenomena are solid indicators for collective behavior. Tissue morphology and, ultimately, tissue function are…”
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Mass cytometry immune profiling to detect signatures of clinical activity of bintrafusp alfa (BA) in patients with advanced non-small cell lung cancer (NSCLC) by McAdams, Meredith, Medina, Carlos, Healy, Connor, Donahue, Renee N., Sigal, Natalia, Enrico, Elizabeth M., Marte, Jenn, Sweere, Jolien, Srinivasan, Ramji, Nguyen, Ngan, Schlom, Jeffrey, Rajan, Arun, Gulley, James L.

“…e21016 Background: BA, a bifunctional fusion protein targeting programed death-ligand 1 and transforming growth factor-β, is clinically active in a subset of…”
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Abstract 2138: Immune features of irAEs and aPD1 response in urothelial cancer patients of the RADIOHEAD study, as detected in blood by mass cytometry immune profiling by Healy, Connor P., Sweere, Johanna M., Liang, Samantha I., Sigal, Natalia, Enrico, Elizabeth, Cheng, Li-Chun, Lucas, Anastasia, Thompson, Marshall A., Da Silva, Diane M., Jarrell, Justin A., Srinivasan, Ramji, Spitzer, Matthew H., Nguyen, Ngan, Spencer, Christine N.

“…Checkpoint immunotherapies (CPI) have resulted in long lasting clinical responses; however, CPI treatment comes with the risk of immune-related adverse events…”
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Positive relationship between risk-taking behaviour and aggression in subordinate but not dominant males of a Cuban poeciliid fish by Bertram, Susan M, Healy, Connor, Hogge, Jessica, Kritikos, Zoe, Pipitone, Jessica, Kolluru, Gita R

“…Studies of integrated phenotypes sometimes reveal correlations between mating effort, favoured by sexual selection, and risk-taking, favoured by survival…”
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