Search Results - "Heal, Jonathan R."

Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity by Haydon, David J, Stokes, Neil R, Ure, Rebecca, Galbraith, Greta, Bennett, James M, Brown, David R, Baker, Patrick J, Barynin, Vladimir V, Rice, David W, Sedelnikova, Sveta E, Heal, Jonathan R, Sheridan, Joseph M, Aiwale, Sachin T, Chauhan, Pramod K, Srivastava, Anil, Taneja, Amit, Collins, Ian, Errington, Jeff, Czaplewski, Lloyd G

“…FtsZ is an essential bacterial guanosine triphosphatase and homolog of mammalian β-tubulin that polymerizes and assembles into a ring to initiate cell…”
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AUTOSTERE: Systematic Search for Scaffold Replacement Opportunities within Structural Databases by Heal, Jonathan R, Sheridan, Joseph M, Kulkarni, Manisha, Liptrott, Neill, Egan, Deirdre, Khoo, Saye, Matthews, Ian, Hamilton, William D. O

“…Medicinal chemists often bias toward working with scaffolds with which previously they have had direct experience and successes. In this way, it is often the…”
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Specific Interactions Between Sense and Complementary Peptides: The Basis for the Proteomic Code by Heal, Jonathan R., Roberts, Gareth W., Raynes, John G., Bhakoo, Ashish, Miller, Andrew D.

“…The discovery of the genetic code was one of the milestone events in biology: a conserved, universal code defining the primary amino acid sequences of all…”
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Yeast Synthetic Biology Platform Generates Novel Chemical Structures as Scaffolds for Drug Discovery by Klein, Jens, Heal, Jonathan R, Hamilton, William D. O, Boussemghoune, Thiamo, Tange, Thomas Østergaard, Delegrange, Fanny, Jaeschke, Georg, Hatsch, Anaëlle, Heim, Jutta

“…Synthetic biology has been heralded as a new bioengineering platform for the production of bulk and specialty chemicals, drugs, and fuels. Here, we report for…”
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Synthesis of novel PPARα/γ dual agonists as potential drugs for the treatment of the metabolic syndrome and diabetes type II designed using a new de novo design program PROTOBUILD by Bhurruth-Alcor, Yushma, Røst, Therese, Jorgensen, Michael R, Kontogiorgis, Christos, Skorve, Jon, Cooper, Robert G, Sheridan, Joseph M, Hamilton, William D O, Heal, Jonathan R, Berge, Rolf K, Miller, Andrew D

“…Peroxisome proliferator activated receptors (PPARs) have been shown to have critical roles in fatty acid oxidation, triglyceride synthesis, and lipid…”
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De-novo design of complementary (antisense) peptide mini-receptor inhibitor of interleukin 18 (IL-18) by Bhakoo, Ashish, Raynes, John G., Heal, Jonathan R., Keller, Michael, Miller, Andrew D.

“…Complementary (antisense) peptide mini-receptor inhibitors are complementary peptides designed to be receptor-surrogates that act by binding to selected…”
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Inhibition of β-Amyloid Aggregation and Neurotoxicity by Complementary (Antisense) Peptides by Heal, Jonathan R., Roberts, Gareth W., Christie, Gary, Miller, Andrew D.

“…Complementary peptides are coded for by the nucleotide sequence (read 5′→3′) of the complementary strand of DNA. By reading the sequence of complementary DNA…”
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Mechanistic Investigation into Complementary (Antisense) Peptide Mini-Receptor Inhibitors of Cytokine Interleukin-1 by Heal, Jonathan R., Bino, Sylvia, Roberts, Gareth W., Raynes, John G., Miller, Andrew D.

“…Sense peptides are coded for by the nucleotide sequence (read 5′→3′) of the sense (positive) strand of DNA. Conversely, a complementary peptide is coded for by…”
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Specific Interactions Between Sense and Complementary Peptides: The Basis for the Proteomic Code by Heal, Jonathan R., Roberts, Gareth W., Raynes, John G., Bhakoo, Ashish, Miller, Andrew D.

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