Search Results - "Heal, J"

Amphetamine, past and present – a pharmacological and clinical perspective by Heal, David J, Smith, Sharon L, Gosden, Jane, Nutt, David J

“…Amphetamine was discovered over 100 years ago. Since then, it has transformed from a drug that was freely available without prescription as a panacea for a…”
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A critical assessment of the abuse, dependence and associated safety risks of naturally occurring and synthetic cannabinoids by Heal, David J, Gosden, Jane, Smith, Sharon L

“…Various countries and US States have legalized cannabis, and the use of the psychoactive and non-psychoactive cannabinoids is steadily increasing. In this…”
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Hypoalbuminaemia and its association with disease and clinical outcomes in cats by Fong, K. Y. M., Oikonomidis, I. L., Leong, D., Lo, G., Heal, J., Woods, G.

“…Objectives To report the incidence of feline hypoalbuminaemia and characterise the distribution of presenting disease categories and pathoaetiologies of…”
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Preclinical assessment of the abuse potential of purified botanical cannabidiol: self-administration, drug discrimination, and physical dependence by Gray, Royston A, Heal, David J, Maguire, David R, Gerak, Lisa R, Javors, Martin A, Smith, Sharon, France, Charles P

“…Cannabidiol (CBD) is a constituent of the cannabis plant with a diverse array of pharmacological activities as well as potential therapeutic uses. An oral…”
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Evaluating the abuse potential of psychedelic drugs as part of the safety pharmacology assessment for medical use in humans by Heal, David J., Gosden, Jane, Smith, Sharon L.

“…Psychedelics comprise drugs come from various pharmacological classes including 5-HT2A agonists, indirect 5-HT agonists, e.g., MDMA, NMDA antagonists and…”
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Evolutionary Developments in Interpreting the  Gluten-Induced Mucosal Celiac Lesion: An  Archimedian Heuristic by Marsh, Michael N, Heal, Calvin J

“…The evolving history of the small intestinal biopsy and its interpretation-and misinterpretations-are described in this paper. Certain interpretative errors in…”
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A preclinical evaluation of the discriminative and reinforcing properties of lisdexamfetamine in comparison to d-amfetamine, methylphenidate and modafinil by Heal, David J., Buckley, Niki W., Gosden, Jane, Slater, Nigel, France, Charles P., Hackett, David

“…Lisdexamfetamine dimesylate, which consists of l-lysine covalently bound to d-amfetamine, is the first prodrug for treating ADHD. Its metabolic conversion to…”
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ABO-immune complex formation and impact on platelet function, red cell structural integrity and haemostasis: an in vitro model of ABO non-identical transfusion by Zaffuto, B. J., Conley, G. W., Connolly, G. C., Henrichs, K. F., Francis, C. W., Heal, J. M., Blumberg, N., Refaai, M. A.

“…Background Transfusion of ABO non‐identical platelets has been associated with fatal haemolytic reactions, increased red cell transfusion needs and other…”
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Inhibition of HIV-1 protease: the rigidity perspective by Heal, J. W., Jimenez-Roldan, J. E., Wells, S. A., Freedman, R. B., Römer, R. A.

“…Motivation: HIV-1 protease is a key drug target due to its role in the life cycle of the HIV-1 virus. Rigidity analysis using the software First is a…”
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Pharmacological Differences Between Rat Frontal Cortex and Hippocampus in the Nicotinic Modulation of Noradrenaline Release Implicate Distinct Receptor Subtypes by Kennett, Alexandra, Heal, David J., Wonnacott, Susan

“…Noradrenergic mechanisms in frontal cortex and hippocampus are relevant to attentional and stress-related aspects of addiction, respectively. Nicotinic…”
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A review of late-stage CNS drug candidates for the treatment of obesity by Heal, D J, Gosden, J, Smith, S L

“…Obesity is an important causative factor in morbidity, disability and premature death. Increasing levels of obesity will impose enormous health, financial and…”
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The neuropharmacology of ADHD drugs in vivo: Insights on efficacy and safety by Heal, D.J., Cheetham, S.C., Smith, S.L.

“…Results from in vivo techniques, especially intracerebral microdialysis in freely-moving rats, have provided insights into potential mechanisms responsible for…”
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Inhibition of alpha7 nicotinic receptors in the ventral hippocampus selectively attenuates reinstatement of morphine‐conditioned place preference and associated changes in AMPA receptor binding by Wright, Victoria L., Georgiou, Polymnia, Bailey, Alexis, Heal, David J., Bailey, Christopher P., Wonnacott, Susan

“…Recurrent relapse is a major problem in treating opiate addiction. Pavlovian conditioning plays a role in recurrent relapse whereby exposure to cues learned…”
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What pharmacological interventions are effective in binge-eating disorder? Insights from a critical evaluation of the evidence from clinical trials by Heal, David J., Gosden, Jane

“…Binge-eating disorder (BED) is the commonest eating disorder and an important causal factor in obesity. Lisdexamfetamine is the only approved pharmacological…”
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Psychedelics – Re-opening the doors of perception by Heal, David J., Henningfield, Jack, Frenguelli, Bruno G., Nutt, David J., Smith, Sharon L.

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Prospects for new drugs to treat binge-eating disorder: Insights from psychopathology and neuropharmacology by Heal, David J, Smith, Sharon L

“…Background: Binge-eating disorder (BED) is a common psychiatric condition with adverse psychological and metabolic consequences. Lisdexamfetamine (LDX) is the…”
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Thermogenic effects of sibutramine and its metabolites by Connoley, Ian P, Liu, Yong‐Ling, Frost, Ian, Reckless, Ian P, Heal, David J, Stock, Michael J

“…The thermogenic activity of the serotonin and noradrenaline reuptake inhibitor sibutramine (BTS 54524; Reductil) was investigated by measuring oxygen…”
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Platelet transfusion and survival in adults with acute leukemia by Blumberg, N, Heal, J M, Liesveld, J L, Phillips, G L, Rowe, J M

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Immunomodulation by blood transfusion: an evolving scientific and clinical challenge by Blumberg, N, Heal, J M

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Stimulant prodrugs: A pharmacological and clinical assessment of their role in treating ADHD and binge-eating disorder by Heal, David J, Gosden, Jane, Smith, Sharon L

“…In this review, we critically evaluate the contribution of prodrugs to treating two related psychiatric disorders, attention-deficit hyperactivity disorder…”
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