Search Results - "Heal, D"

Experimental strategies to discover and develop the next generation of psychedelics and entactogens as medicines by Heal, D.J., Gosden, J., Smith, S.L., Atterwill, C.K.

“…Research on classical psychedelics (psilocybin, LSD and DMT) and entactogen, MDMA, has produced a renaissance in the search for more effective drugs to treat…”
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Psychedelics: Threshold of a Therapeutic Revolution by Heal, D.J., Smith, S.L., Belouin, S.J., Henningfield, J.E.

“…This Special Issue of Neuropharmacology on psychedelics provides a timely and comprehensive update on progress following the previous Neuropharmacology Special…”
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Face masks: protecting the wearer but neglecting the aquatic environment? - A perspective from Bangladesh by Hasan, Neaz A., Heal, Richard D, Bashar, Abul, Haque, Mohammad Mahfujul

“…•An estimate of COVID-related single-use plastic usage and waste in Bangladesh is provided.•The potential impact of single-use face masks on plastic pollution…”
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The neuropharmacology of ADHD drugs in vivo: Insights on efficacy and safety by Heal, D.J., Cheetham, S.C., Smith, S.L.

“…Results from in vivo techniques, especially intracerebral microdialysis in freely-moving rats, have provided insights into potential mechanisms responsible for…”
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COVID-19 impacts on the Bangladesh shrimp industry: A sequential survey-based case study from southwestern Bangladesh by Bashar, Abul, Heal, Richard D., Hasan, Neaz A., Salam, Md. Abdus, Haque, Mohammad Mahfujul

“…Shrimp farming is fundamental to the national economy of Bangladesh, particularly through earning foreign currency. The nationwide lockdown and international…”
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Selective 5-HT6 receptor ligands: progress in the development of a novel pharmacological approach to the treatment of obesity and related metabolic disorders by Heal, D J, Smith, S L, Fisas, A, Codony, X, Buschmann, H

“…The increasing global prevalence of obesity unequivocally demonstrates that neither behavioural (diet and exercise) nor pharmacological approaches to this…”
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Preclinical assessment of the abuse potential of purified botanical cannabidiol: self-administration, drug discrimination, and physical dependence by Gray, Royston A, Heal, David J, Maguire, David R, Gerak, Lisa R, Javors, Martin A, Smith, Sharon, France, Charles P

“…Cannabidiol (CBD) is a constituent of the cannabis plant with a diverse array of pharmacological activities as well as potential therapeutic uses. An oral…”
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A review of late-stage CNS drug candidates for the treatment of obesity by Heal, D J, Gosden, J, Smith, S L

“…Obesity is an important causative factor in morbidity, disability and premature death. Increasing levels of obesity will impose enormous health, financial and…”
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Lisdexamfetamine and immediate release d-amfetamine – Differences in pharmacokinetic/pharmacodynamic relationships revealed by striatal microdialysis in freely-moving rats with simultaneous determination of plasma drug concentrations and locomotor activity by Rowley, H.L., Kulkarni, R., Gosden, J., Brammer, R., Hackett, D., Heal, D.J.

“…Lisdexamfetamine mesylate (Vyvanse®) is a novel prodrug approved for attention deficit hyperactivity disorder (ADHD). It is metabolised to d-amfetamine and…”
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New perspectives from microdialysis studies in freely-moving, spontaneously hypertensive rats on the pharmacology of drugs for the treatment of ADHD by Heal, D.J., Smith, S.L., Kulkarni, R.S., Rowley, H.L.

“…Attention deficit hyperactivity disorder (ADHD) is a common childhood psychiatric condition that is effectively treated by catecholaminergic drugs with a…”
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P.1.g.074 Acquired binge-eating behaviour produces alterations in dopaminergic neurochemistry in the brains of rats by Heal, D, Gosden, J, Prow, M.R, Hutson, P.H, Cheetham, S.C

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P.6.c.020 Progressive ratio determination of the relative reinforcing effect of methylphenidate versus cocaine by self-administration testing in rats by Heal, D, Buckley, N.W, Johnson, E.L, Gosden, J, Smith, S.L

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P.1.g.032 Metabolic effects of lisdexamfetamine in a rat model of human obesity with insulin resistance by Heal, D, Vickers, S, Hackett, D, Hutson, P

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P.1.g.034 Effect of lisdexamfetamine in a rat model of binge-eating disorder by Heal, D, Vickers, S, Hackett, D, Hutson, P

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Increasing disease burden and use of drugs and chemicals in Bangladesh shrimp aquaculture: A potential menace to human health by Heal, Richard D., Hasan, Neaz A., Haque, Mohammad Mahfujul

“…Using structured surveys in 2008 and 2016, change in disease burden and use of chemical treatments in Bangladesh shrimp farm management was examined. Overall,…”
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Sibutramine: a novel anti-obesity drug. A review of the pharmacological evidence to differentiate it from d-amphetamine and d-fenfluramine by Heal, D J, Aspley, S, Prow, M R, Jackson, H C, Martin, K F, Cheetham, S C

“…Sibutramine (BTS 54 524; N-[1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl]-N,N-dimethylamine hydrochloride monohydrate) is a novel 5-HT (serotonin) and…”
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A comparison of the effects on central 5‐HT function of sibutramine hydrochloride and other weight‐modifying agents by Heal, D J, Cheetham, S C, Prow, M R, Martin, K F, Buckett, W R

“…1 Effects on 5‐HT function of sibutramine and its active metabolites, BTS 54 354 and BTS 54 505, were compared with fluoxetine, (+)‐fenfluramine and…”
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Thermogenic effects of sibutramine and its metabolites by Connoley, Ian P, Liu, Yong‐Ling, Frost, Ian, Reckless, Ian P, Heal, David J, Stock, Michael J

“…The thermogenic activity of the serotonin and noradrenaline reuptake inhibitor sibutramine (BTS 54524; Reductil) was investigated by measuring oxygen…”
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In vivo criteria to differentiate monoamine reuptake inhibitors from releasing agents: sibutramine is a reuptake inhibitor by Gundlah, C, Martin, K F, Heal, D J, Auerbach, S B

“…Because monoamine reuptake inhibitors and releasing agents both increase extracellular neurotransmitter levels, establishing in vivo experimental criteria for…”
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Pharmacological Differences Between Rat Frontal Cortex and Hippocampus in the Nicotinic Modulation of Noradrenaline Release Implicate Distinct Receptor Subtypes by Kennett, Alexandra, Heal, David J., Wonnacott, Susan

“…Noradrenergic mechanisms in frontal cortex and hippocampus are relevant to attentional and stress-related aspects of addiction, respectively. Nicotinic…”
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