Neuroinflammation: Breaking barriers and bridging gaps

Neuroinflammation: Breaking barriers and bridging gaps

Neurons are the cells of the nervous system and are responsible for every thought, movement and perception. Immune cells are the cells of the immune system, constantly protecting from foreign pathogens. Understanding the interaction between the two systems is especially important in disease states s...

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Bibliographic Details
Published in:Neuroscience research Vol. 197; pp. 9 - 17
Main Authors: Estera, Lora A, Walsh, Sam P, Headen, Jordan A, Williamson, Rachel E, Kalinski, Ashley L
Format: Journal Article
Language:English
Published: Ireland 01-12-2023
Subjects:
Axons - physiology
Humans
Nerve Regeneration - physiology
Neurodegenerative Diseases
Neuroinflammatory Diseases
Neurons - physiology
Wallerian degeneration
Axon regeneration
Efferocytosis
Nerve injury
Neuroinflammation
Microenvironment
Macrophages
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Summary:Neurons are the cells of the nervous system and are responsible for every thought, movement and perception. Immune cells are the cells of the immune system, constantly protecting from foreign pathogens. Understanding the interaction between the two systems is especially important in disease states such as autoimmune or neurodegenerative disease. Unfortunately, this interaction is typically detrimental to the host. However, recent efforts have focused on how neurons and immune cells interact, either directly or indirectly, following traumatic injury to the nervous system. The outcome of this interaction can be beneficial - leading to successful neural repair, or detrimental - leading to functional deficits, depending on where the injury occurs. This review will discuss our understanding of neuron-immune cell interactions after traumatic injury to both the peripheral and central nervous system.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0168-0102
1872-8111
DOI:10.1016/j.neures.2021.11.001