Search Results - "Head, Stewart I."

Age- and gender-related changes in contractile properties of non-atrophied EDL muscle by Chan, Stephen, Head, Stewart I

“…In humans, ageing causes skeletal muscles to become atrophied, weak, and easily fatigued. In rodent studies, ageing has been associated with significant muscle…”
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Six weeks of N-acetylcysteine antioxidant in drinking water decreases pathological fiber branching in MDX mouse dystrophic fast-twitch skeletal muscle by Redwan, Asma, Kiriaev, Leonit, Kueh, Sindy, Morley, John W, Houweling, Peter, Perry, Ben D, Head, Stewart I

“…It has been proposed that an increased susceptivity to oxidative stress caused by the absence of the protein dystrophin from the inner surface of the…”
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Lifespan Analysis of Dystrophic mdx Fast-Twitch Muscle Morphology and Its Impact on Contractile Function by Kiriaev, Leonit, Kueh, Sindy, Morley, John W, North, Kathryn N, Houweling, Peter J, Head, Stewart I

“…Duchenne muscular dystrophy is caused by the absence of the protein dystrophin from skeletal muscle and is characterized by progressive cycles of…”
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Altered Ca2+ kinetics associated with α-actinin-3 deficiency may explain positive selection for ACTN3 null allele in human evolution by Head, Stewart I, Chan, Stephen, Houweling, Peter J, Quinlan, Kate G R, Murphy, Robyn, Wagner, Sören, Friedrich, Oliver, North, Kathryn N

“…Over 1.5 billion people lack the skeletal muscle fast-twitch fibre protein α-actinin-3 due to homozygosity for a common null polymorphism (R577X) in the ACTN3…”
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Minocycline Treatment Reduces Mass and Force Output From Fast-Twitch Mouse Muscles and Inhibits Myosin Production in C2C12 Myotubes by Kiriaev, Leonit, Perry, Ben D., Mahns, David A., Shortland, Peter J., Redwan, Asma, Morley, John W., Head, Stewart I.

“…Minocycline, a tetracycline-class of antibiotic, has been tested with mixed effectiveness on neuromuscular disorders such as amyotrophic lateral sclerosis,…”
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Absence of the Z-disc protein α-actinin-3 impairs the mechanical stability of Actn3KO mouse fast-twitch muscle fibres without altering their contractile properties or twitch kinetics by Haug, Michael, Reischl, Barbara, Nübler, Stefanie, Kiriaev, Leonit, Mázala, Davi A. G., Houweling, Peter J., North, Kathryn N., Friedrich, Oliver, Head, Stewart I.

“…Abstract Background A common polymorphism (R577X) in the ACTN3 gene results in the complete absence of the Z-disc protein α-actinin-3 from fast-twitch muscle…”
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Incubating isolated mouse EDL muscles with creatine improves force production and twitch kinetics in fatigue due to reduction in ionic strength by Head, Stewart I, Greenaway, Bronwen, Chan, Stephen

“…Creatine supplementation can improve performance during high intensity exercise in humans and improve muscle strength in certain myopathies. In this present…”
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Assessment of Cell Viability in Electrically Excitable Muscle Cells Through Intact Twitch Stimulation by Bauer, Julian, Head, Stewart I, Friedrich, Oliver

“…Muscle cells (i.e. skeletal muscle fibers) are fully viable and functional when their excitation-contraction (EC) coupling machinery is intact. This involves…”
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Antioxidant therapy in a mouse model of Duchenne muscular dystrophy: some promising results but with a weighty caveat by Head, Stewart I.

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RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility by Yu, Ze-Yan, Tan, Ju-Chiat, McMahon, Aisling C, Iismaa, Siiri E, Xiao, Xiao-Hui, Kesteven, Scott H, Reichelt, Melissa E, Mohl, Marion C, Smith, Nicola J, Fatkin, Diane, Allen, David, Head, Stewart I, Graham, Robert M, Feneley, Michael P

“…To determine the mechanisms by which the α1A-adrenergic receptor (AR) regulates cardiac contractility. We reported previously that transgenic mice with…”
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Properties of extensor digitorum longus muscle and skinned fibers from adult and aged male and female Actn3 knockout mice by Chan, Stephen, Seto, Jane T., Houweling, Peter J., Yang, Nan, North, Kathryn N., Head, Stewart I.

“…Absence of α‐actinin‐3, encoded by the ACTN3 “speed gene,” is associated with poorer sprinting performance in athletes and a slowing of relaxation in…”
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Branched fibres in old dystrophic mdx muscle are associated with mechanical weakening of the sarcolemma, abnormal Ca2+ transients and a breakdown of Ca2+ homeostasis during fatigue by Head, Stewart I.

“…In the dystrophinopathies, skeletal muscle fibres undergo cycles of degeneration and regeneration, with regenerated fibres displaying a branched morphology…”
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Gadolinium reduces short-term stretch-induced muscle damage in isolated mdx mouse muscle fibres by Yeung, Ella W, Head, Stewart I, Allen, David G

“…Duchenne muscular dystrophy is a lethal muscle disease caused by absence of the protein dystrophin which is part of a glycoprotein complex located on the…”
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Membrane Injury and Repair in the Muscular Dystrophies by Cooper, Sandra T., Head, Stewart I.

“…Muscle cells have an elaborate plasma membrane and t-tubule system that has been evolutionarily refined to maximize electrical conductivity for synchronous…”
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Loss of α-actinin-3 confers protection from eccentric contraction damage in fast-twitch EDL muscles from aged mdx dystrophic mice by reducing pathological fibre branching by Kiriaev, Leonit, Houweling, Peter J, North, Kathryn N, Head, Stewart I

“…Abstract The common null polymorphism (R577X) in the ACTN3 gene is present in over 1.5 billion people worldwide and results in the absence of the protein…”
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Calcium and strontium contractile activation properties of single skinned skeletal muscle fibres from elderly women 66–90 years of age by Ronaldson, Susan M., Stephenson, D. George, Head, Stewart I.

“…The single freshly skinned muscle fibre technique was used to investigate Ca 2+ - and Sr 2+ -activation properties of skeletal muscle fibres from elderly women…”
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Dystrophin-negative slow-twitch soleus muscles are not susceptible to eccentric contraction induced injury over the lifespan of the mdx mouse by Kiriaev, Leonit, Kueh, Sindy, Morley, John W, Houweling, Peter J, Chan, Stephen, North, Kathryn N, Head, Stewart I

“…Duchenne muscular dystrophy (DMD) is the second most common fatal genetic disease in humans and is characterized by the absence of a functional copy of the…”
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Sarcoplasmic reticulum calcium handling in unbranched, immediately post‐necrotic fast‐twitch mdx fibres is similar to wild‐type littermates by Chan, Stephen, Kueh, Sindy L. L., Morley, John W., Head, Stewart I.

“…New Findings What is the central question of this study? What are the early effects of dystrophin deficiency on sarcoplasmic reticulum Ca2+ handling in the mdx…”
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Single muscle fibre biomechanics and biomechatronics – The challenges, the pitfalls and the future by Friedrich, Oliver, Haug, Michael, Reischl, B, Prölß, G, Kiriaev, Leon, Head, Stewart I, Reid, Michael B

“…Interest in muscle biomechanics is growing with availabilities of patient biopsies and animal models related to muscle diseases, muscle wasting (sarcopenia,…”
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Analysis of the ACTN3 heterozygous genotype suggests that α-actinin-3 controls sarcomeric composition and muscle function in a dose-dependent fashion by Hogarth, Marshall W, Garton, Fleur C, Houweling, Peter J, Tukiainen, Taru, Lek, Monkol, Macarthur, Daniel G, Seto, Jane T, Quinlan, Kate G R, Yang, Nan, Head, Stewart I, North, Kathryn N

“…A common null polymorphism (R577X) in ACTN3 causes α-actinin-3 deficiency in ∼ 18% of the global population. There is no associated disease phenotype, but…”
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