Search Results - "Head, Geoff A."

Sustained Decrease in Blood Pressure and Reduced Anatomical and Functional Reinnervation of Renal Nerves in Hypertensive Sheep 30 Months After Catheter-Based Renal Denervation by Singh, Reetu R, McArdle, Zoe M, Iudica, Michael, Easton, Lawrence K, Booth, Lindsea C, May, Clive N, Parkington, Helena C, Lombardo, Paul, Head, Geoff A, Lambert, Gavin, Moritz, Karen M, Schlaich, Markus P, Denton, Kate M

“…We examined whether renal denervation (RDN) reduced blood pressure (BP), improved glomerular filtration rate, albuminuria, and left ventricular mass in sheep…”
Get full text

Chronic sympathetic driven hypertension promotes atherosclerosis by enhancing hematopoiesis by Al-Sharea, Annas, Lee, Man K S, Whillas, Alexandra, Michell, Danielle L, Shihata, Waled A, Nicholls, Alyce J, Cooney, Olivia D, Kraakman, Michael J, Veiga, Camilla Bertuzzo, Jefferis, Ann-Maree, Jackson, Kristy, Nagareddy, Prabhakara R, Lambert, Gavin, Wong, Connie H Y, Andrews, Karen L, Head, Geoff A, Chin-Dusting, Jaye, Murphy, Andrew J

“…Hypertension is a major, independent risk factor for atherosclerotic cardiovascular disease. However, this pathology can arise through multiple pathways, which…”
Get full text

SGLT2 Inhibitor-Induced Sympathoinhibition: A Novel Mechanism for Cardiorenal Protection by Herat, Lakshini Y, Magno, Aaron L, Rudnicka, Caroline, Hricova, Jana, Carnagarin, Revathy, Ward, Natalie C, Arcambal, Angelique, Kiuchi, Marcio G, Head, Geoff A, Schlaich, Markus P, Matthews, Vance B

“…Recent clinical trial data suggest a cardiorenal protective effect of sodium glucose cotransporter 2 (SGLT2) inhibition. We demonstrate that chemical…”
Get full text

Increase in Bioavailability of Nitric Oxide After Renal Denervation Improves Kidney Function in Sheep With Hypertensive Kidney Disease by Singh, Reetu R., McArdle, Zoe M., Booth, Lindsea C., May, Clive N., Head, Geoff A., Moritz, Karen M., Schlaich, Markus P., Denton, Kate M.

“…Overactivity of renal sympathetic nerves and nitric oxide (NO) deficiency occur in hypertensive chronic kidney disease (CKD). In sheep with hypertensive CKD…”
Get full text

Renal Denervation in Combination With Angiotensin Receptor Blockade Prolongs Blood Pressure Trough During Hemorrhage by Singh, Reetu R., McArdle, Zoe, Booth, Lindsea C., May, Clive N., Head, Geoff A., Moritz, Karen M., Schlaich, Markus P., Denton, Kate M.

“…Majority of patients with hypertension and chronic kidney disease (CKD) undergoing renal denervation (RDN) are maintained on antihypertensive medication…”
Get full text

Ensuring Animal Welfare While Meeting Scientific Aims Using a Murine Pneumonia Model of Septic Shock by Huet, Olivier, Ramsey, Debbie, Miljavec, Sandra, Jenney, Adam, Aubron, Cecile, Aprico, Andrea, Stefanovic, Nada, Balkau, Beverley, Head, Geoff A, de Haan, Judy B, Chin-Dusting, Jaye P F

“…ABSTRACTWith animal models, death as an intentional end point is ethically unacceptable. However, in the study of septic shock, death is still considered the…”
Get full text

SGLT2 Inhibitor–Induced Sympathoinhibition by Herat, Lakshini Y., Magno, Aaron L., Rudnicka, Caroline, Hricova, Jana, Carnagarin, Revathy, Ward, Natalie C., Arcambal, Angelique, Kiuchi, Marcio G., Head, Geoff A., Schlaich, Markus P., Matthews, Vance B.

“…[Display omitted] •SGLT2 inhibitors improve cardiovascular outcomes.•SGLT2 inhibitor–induced sympathetic nervous system inhibition may be an underlying…”
Get full text

Contribution of renal nerves to renal blood flow variability during hemorrhage by Malpas, S C, Evans, R G, Head, G A, Lukoshkova, E V

“…We have examined the role of the renal sympathetic nerves in the renal blood flow (RBF) response to hemorrhage in seven conscious rabbits. Hemorrhage was…”
Get full text

Renal Denervation in Combination With Angiotensin Receptor Blockade Prolongs Blood Pressure Trough During Hemorrhage by Singh, Reetu R., McArdle, Zoe, Booth, Lindsea C., May, Clive N., Head, Geoff A., Moritz, Karen M., Schlaich, Markus P., Denton, Kate M.

“…Majority of patients with hypertension and chronic kidney disease (CKD) undergoing renal denervation (RDN) are maintained on antihypertensive medication…”
Get full text

Increase in Bioavailability of Nitric Oxide After Renal Denervation Improves Kidney Function in Sheep With Hypertensive Kidney Disease by Singh, Reetu R., McArdle, Zoe M., Booth, Lindsea C., May, Clive N., Head, Geoff A., Moritz, Karen M., Schlaich, Markus P., Denton, Kate M.

“…Overactivity of renal sympathetic nerves and nitric oxide (NO) deficiency occur in hypertensive chronic kidney disease (CKD). In sheep with hypertensive CKD…”
Get full text

Abstract P608: Role Of Nitric Oxide In The Pathophysiology Of Hypertension Associated With Low Nephron Endowment by Singh, Reetu R, Easton, Lawerance K, Schlaich, Markus P, Head, Geoff A, Moritz, Karen M, Denton, Kate

“…Abstract only A low nephron endowment is a strong predictor for future risk of hypertension, kidney and cardiovascular disease. Previously, we have shown that…”
Get full text

Imidazoline receptors, novel agents and therapeutic potential by Head, G A, Mayorov, D N

“…The initial realization that agents containing an imidazoline structure may interact with a distinct class of receptors, has led to a major class of…”
Get more information

Role of angiotensin in the rostral ventrolateral medulla in the pressor response to aversive stress by Chen, Daian, Nguyen‐Huu, Thu‐Phuc, Bassi, Jaspreet K, Davern, Pamela, Thomas, Walter G, Head, Geoff A, Allen, Andrew M

“…Mice with global knockout of the AT1AR have an attenuated pressor response to aversive stress. Under isoflurane anesthesia, AT1AR knockout (AT1A−/−) mice were…”
Get full text