Search Results - "Hédou, Gaël"

Discovery, Structure–Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4 by Charvin, Delphine, Pomel, Vincent, Ortiz, Millan, Frauli, Mélanie, Scheffler, Sophie, Steinberg, Edith, Baron, Luc, Deshons, Laurène, Rudigier, Rachel, Thiarc, Delphine, Morice, Christophe, Manteau, Baptiste, Mayer, Stanislas, Graham, Danielle, Giethlen, Bruno, Brugger, Nadia, Hédou, Gaël, Conquet, François, Schann, Stephan

“…The metabotropic glutamate receptor 4 (mGluR4) is an emerging target for the treatment of Parkinson’s disease (PD). However, since the discovery of its…”
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Inducible molecular switches for the study of long-term potentiation by Hédou, Gaël, Mansuy, Isabelle M.

“…This article reviews technical and conceptual advances in unravelling the molecular bases of long-term potentiation (LTP), learning and memory using genetic…”
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An automated analysis of rat behavior in the forced swim test by Hédou, Gaël, Pryce, Christopher, Di Iorio, Lucia, Heidbreder, Christian A, Feldon, Joram

“…The Porsolt forced swim test (FST) is a commonly used paradigm to evaluate antidepressant activity of drugs. This test is based on visual measurement of the…”
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Sensitized Fos expression in subterritories of the rat medial prefrontal cortex and nucleus accumbens following amphetamine sensitization as revealed by stereology by Hédou, Gaël, Jongen-Rêlo, Ana Lúcia, Murphy, Carol A, Heidbreder, Christian A, Feldon, Joram

“…Behavioral sensitization to the locomotor activating effects of amphetamine refers to the progressive, long lasting increase in locomotor activity that occurs…”
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Partial inhibition of PP1 alters bidirectional synaptic plasticity in the hippocampus by Jouvenceau, Anne, Hédou, Gael, Potier, Brigitte, Kollen, Mélanie, Dutar, Patrick, Mansuy, Isabelle M.

“…Synaptic plasticity is an important cellular mechanism that underlies memory formation. In brain areas involved in memory such as the hippocampus, long‐term…”
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Expression of sensitization to amphetamine and dynamics of dopamine neurotransmission in different laminae of the rat medial prefrontal cortex by Hedou, Gaël, Homberg, Judith, Feldon, Joram, Heidbreder, Christian A.

“…The present study investigated the effect of acute and repeated administrations of amphetamine (AMPH) on dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC),…”
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SON-1210 - a novel bifunctional IL-12 / IL-15 fusion protein that improves cytokine half-life, targets tumors, and enhances therapeutic efficacy by Cini, John K, Dexter, Susan, Rezac, Darrel J, McAndrew, Stephen J, Hedou, Gael, Brody, Rich, Eraslan, Rukiye-Nazan, Kenney, Richard T, Mohan, Pankaj

“…The potential synergy between interleukin-12 (IL-12) and IL-15 holds promise for more effective solid tumor immunotherapy. Nevertheless, previous clinical…”
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Low-Dose Pulsatile Interleukin-6 As a Treatment Option for Diabetic Peripheral Neuropathy by Cox, April Ann, Sagot, Yves, Hedou, Gael, Grek, Christina, Wilkes, Travis, Vinik, Aaron I, Ghatnekar, Gautam

“…Diabetic peripheral neuropathy (DPN) remains one of the most common and serious complications of diabetes. Currently, pharmacological agents are limited to…”
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Protein Phosphatase 1-Dependent Bidirectional Synaptic Plasticity Controls Ischemic Recovery in the Adult Brain by Hedou, Gael F, Koshibu, Kyoko, Farinelli, Melissa, Kilic, Ertugrul, Gee, Christine E, Kilic, Ulkan, Baumgartel, Karsten, Hermann, Dirk M, Mansuy, Isabelle M

“…Protein kinases and phosphatases can alter the impact of excitotoxicity resulting from ischemia by concurrently modulating apoptotic/survival pathways. Here,…”
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The orexin-1 receptor antagonist SB-334867 reduces amphetamine-evoked dopamine outflow in the shell of the nucleus accumbens and decreases the expression of amphetamine sensitization by Quarta, Davide, Valerio, Enzo, Hutcheson, Daniel M., Hedou, Gael, Heidbreder, Christian

“…Orexin-expressing neurons are present in hypothalamic nuclei and send projections toward mesolimbic regions such as the nucleus accumbens (NAc), a key brain…”
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Immunohistochemical studies of the localization of neurons containing the enzyme that synthesizes dopamine, GABA, or γ-hydroxybutyrate in the rat substantia nigra and striatum by Hédou, Gaël, Chasserot-Golaz, Sylvette, Kemmel, Véronique, Gobaille, Serge, Roussel, Guy, Artault, Jean-Claude, Andriamampandry, Christian, Aunis, Dominique, Maitre, Michel

“…γ‐Hydroxybutyrate (GHB) is an endogenous metabolite of γ‐aminobutyric acid (GABA), which is synthesized in the neuronal compartment of the central nervous…”
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Systemic administration of ghrelin increases extracellular dopamine in the shell but not the core subdivision of the nucleus accumbens by Quarta, Davide, Di Francesco, Carla, Melotto, Sergio, Mangiarini, Laura, Heidbreder, Christian, Hedou, Gael

“…The gut-hormone ghrelin endogenously binds to the ghrelin receptor (GHS-R) to promote foraging and feeding behaviours mainly via the hypothalamic arcuate…”
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Abstract 7181: Low dose interleukin-6 (SON-080) for neuropathies: Toxicology and clinical plans by Dexter, Susan, Hedou, Gael, Kenney, Richard T., Rezac, Darrel J., Mohan, Pankaj

“…Neuropathies are conditions in which peripheral nerves degenerate, resulting in sensory and motor symptoms that can profoundly affect the patients’ quality of…”
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Effects of cocaine on dopamine in subregions of the rat prefrontal cortex and their efferents to subterritories of the nucleus accumbens by Hedou, Gaël, Feldon, Joram, Heidbreder, Christian A

“…The present study sought to investigate the contributions of the ventral prelimbic/infralimbic cortices and shell subterritory of the nucleus accumbens as well…”
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Effect of amphetamine on extracellular acetylcholine and monoamine levels in subterritories of the rat medial prefrontal cortex by Hedou, Gaël, Homberg, Judith, Martin, Sonsoles, Wirth, Katja, Feldon, Joram, Heidbreder, Christian A

“…The present study sought to investigate the contributions of the dorsal prelimbic/anterior cingulate and ventral prelimbic/infralimbic cortices to the reverse…”
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Amphetamine Microinfusion in the Dorso-Ventral Axis of the Prefrontal Cortex Differentially Modulates Dopamine Neurotransmission in the Shell-Core Subterritories of the Nucleus Accumbens by HEDOU, GAËL, HOMBERG, JUDITH, FELDON, JORAM, HEIDBREDER, CHRISTIAN A.

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Rapid communication: Systemic administration of ghrelin increases extracellular dopamine in the shell but not the core subdivision of the nucleus accumbens by Quarta, Davide, Di Francesco, Carla, Melotto, Sergio, Mangiarini, Laura, Heidbreder, Christian, Hedou, Gael

“…The gut-hormone ghrelin endogenously binds to the ghrelin receptor (GHS-R) to promote foraging and feeding behaviours mainly via the hypothalamic arcuate…”
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Behavioral neurochemistry reveals a new functional dichotomy in the shell subregion of the nucleus accumbens by Heidbreder, Christian A., Hedou, Gael, Feldon, Joram

“…1. 1. The behavioral and neurochemical effects produced by the direct infusion of amphetamine by reverse microdialysis into either the core or shell of the…”
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