Search Results - "He, Zhonggui"

ROS-responsive drug delivery systems for biomedical applications by Tao, Wenhui, He, Zhonggui

“…In the field of biomedicine, stimuli-responsive drug delivery systems (DDSs) have become increasingly popular due to their site-specific release ability in…”
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Prodrug-based nanoparticulate drug delivery strategies for cancer therapy by Luo, Cong, Sun, Jin, Sun, Bingjun, He, Zhonggui

“…Highlights • Recent trends in prodrug-based nanocarriers for cancer therapy are provided. • Stimuli-sensitive nanoparticulate drug delivery systems (Nano-DDS)…”
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Chemotherapy agent-unsaturated fatty acid prodrugs and prodrug-nanoplatforms for cancer chemotherapy by Sun, Bingjun, Luo, Cong, Cui, Weiping, Sun, Jin, He, Zhonggui

“…Unsaturated fatty acids (UFAs), with the distinct advantages of good biocompatibility and innate tumor-targeting effect, have been widely investigated for the…”
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Emerging role of natural products in cancer immunotherapy by Dong, Songtao, Guo, Xiangnan, Han, Fei, He, Zhonggui, Wang, Yongjun

“…Cancer immunotherapy has become a new generation of anti-tumor treatment, but its indications still focus on several types of tumors that are sensitive to the…”
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The endocytosis and intracellular fate of nanomedicines: Implication for rational design by Kou, Longfa, Sun, Jin, Zhai, Yinglei, He, Zhonggui

“…Nanomedicines employ multiple endocytic pathways to enter cells. Their following fate is interesting, but it is not sufficient understood currently. This…”
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Probing the impact of sulfur/selenium/carbon linkages on prodrug nanoassemblies for cancer therapy by Sun, Bingjun, Luo, Cong, Zhang, Xuanbo, Guo, Mengran, Sun, Mengchi, Yu, Han, Chen, Qin, Yang, Wenqian, Wang, Menglin, Zuo, Shiyi, Chen, Pengyu, Kan, Qiming, Zhang, Haotian, Wang, Yongjun, He, Zhonggui, Sun, Jin

“…Tumor cells are characterized as redox-heterogeneous intracellular microenvironment due to the simultaneous overproduction of reactive oxygen species and…”
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Bacteria-Mediated Synergistic Cancer Therapy: Small Microbiome Has a Big Hope by Lou, Xinyu, Chen, Zhichao, He, Zhonggui, Sun, Mengchi, Sun, Jin

“…Highlights Introducing mechanisms of antitumor activation produced by bacteria-mediated bio-therapy in detail. Comprehensively reviewing multiple…”
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Nanosponges of circulating tumor-derived exosomes for breast cancer metastasis inhibition by Ye, Hao, Wang, Kaiyuan, Lu, Qi, Zhao, Jian, Wang, Menglin, Kan, Qiming, Zhang, Haotian, Wang, Yongjun, He, Zhonggui, Sun, Jin

“…Breast cancer contributes to high mortality rates as a result of metastasis. Tumor-derived exosomes facilitate the development of the premetastatic…”
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Gas therapy potentiates aggregation-induced emission luminogen-based photoimmunotherapy of poorly immunogenic tumors through cGAS-STING pathway activation by Wang, Kaiyuan, Li, Yang, Wang, Xia, Zhang, Zhijun, Cao, Liping, Fan, Xiaoyuan, Wan, Bin, Liu, Fengxiang, Zhang, Xuanbo, He, Zhonggui, Zhou, Yingtang, Wang, Dong, Sun, Jin, Chen, Xiaoyuan

“…The immunologically “cold” microenvironment of triple negative breast cancer results in resistance to current immunotherapy. Here, we reveal the immunoadjuvant…”
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Molecularly self‐fueled nano-penetrator for nonpharmaceutical treatment of thrombosis and ischemic stroke by Zhang, Hongyuan, Zhao, Zhiqiang, Sun, Shengnan, Zhang, Sen, Wang, Yuequan, Zhang, Xuanbo, Sun, Jin, He, Zhonggui, Zhang, Shenwu, Luo, Cong

“…Thrombotic cerebro-cardiovascular diseases are the leading causes of disability and death worldwide. However, current drug therapeutics are compromised by…”
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Recent progress of hypoxia-modulated multifunctional nanomedicines to enhance photodynamic therapy: opportunities, challenges, and future development by Sun, Yixin, Zhao, Dongyang, Wang, Gang, Wang, Yang, Cao, Linlin, Sun, Jin, Jiang, Qikun, He, Zhonggui

“…Hypoxia, a salient feature of most solid tumors, confers invasiveness and resistance to the tumor cells. Oxygen-consumption photodynamic therapy (PDT) suffers…”
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High Co-loading Capacity and Stimuli-Responsive Release Based on Cascade Reaction of Self-Destructive Polymer for Improved Chemo-Photodynamic Therapy by Wang, Menglin, Zhai, Yinglei, Ye, Hao, Lv, Qingzhi, Sun, Bingjun, Luo, Cong, Jiang, Qikun, Zhang, Haotian, Xu, Youjun, Jing, Yongkui, Huang, Leaf, Sun, Jin, He, Zhonggui

“…Photodynamic therapy (PDT) shows a promising synergy with chemotherapy in the therapeutic outcome of malignant cancers. The minimal invasiveness and…”
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Transporter-Guided Delivery of Nanoparticles to Improve Drug Permeation across Cellular Barriers and Drug Exposure to Selective Cell Types by Kou, Longfa, Bhutia, Yangzom D, Yao, Qing, He, Zhonggui, Sun, Jin, Ganapathy, Vadivel

“…Targeted nano-drug delivery systems conjugated with specific ligands to target selective cell-surface receptors or transporters could enhance the efficacy of…”
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Molecularly Self-Engineered Nanoamplifier for Boosting Photodynamic Therapy via Cascade Oxygen Elevation and Lipid ROS Accumulation by Zhang, Shenwu, Sun, Xinxin, Wang, Ziyue, Sun, Jin, He, Zhonggui, Sun, Bingjun, Luo, Cong

“…Photodynamic therapy (PDT) has been extensively explored as a noninvasive cancer treatment modality. However, the dilemma of tumor hypoxia and short half-life…”
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Hybrid chalcogen bonds in prodrug nanoassemblies provides dual redox-responsivity in the tumor microenvironment by Liu, Tian, Li, Lingxiao, Wang, Shuo, Dong, Fudan, Zuo, Shiyi, Song, Jiaxuan, Wang, Xin, Lu, Qi, Wang, Helin, Zhang, Haotian, Cheng, Maosheng, Liu, Xiaohong, He, Zhonggui, Sun, Bingjun, Sun, Jin

“…Sulfur bonds, especially trisulfide bond, have been found to ameliorate the self-assembly stability of homodimeric prodrug nanoassemblies and could trigger the…”
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Engineered bacterial outer membrane vesicles encapsulating oncolytic adenoviruses enhance the efficacy of cancer virotherapy by augmenting tumor cell autophagy by Ban, Weiyue, Sun, Mengchi, Huang, Hanwei, Huang, Wanxu, Pan, Siwei, Liu, Pengfei, Li, Bingwu, Cheng, Zhenguo, He, Zhonggui, Liu, Funan, Sun, Jin

“…Oncolytic adenovirus (Ad) infection promotes intracellular autophagy in tumors. This could kill cancer cells and contribute to Ads-mediated anticancer…”
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Disulfide Bond Bridge Insertion Turns Hydrophobic Anticancer Prodrugs into Self-Assembled Nanomedicines by Wang, Yongjun, Liu, Dan, Zheng, Qingchuan, Zhao, Qiang, Zhang, Hongjuan, Ma, Yan, Fallon, John K, Fu, Qiang, Haynes, Matthew T, Lin, Guimei, Zhang, Rong, Wang, Dun, Yang, Xinggang, Zhao, Linxiang, He, Zhonggui, Liu, Feng

“…It is commonly observed that hydrophobic molecules alone cannot self-assemble into stable nanoparticles, requiring amphiphilic or ionic materials to support…”
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Recent advances in bacteriophage-based therapeutics: Insight into the post-antibiotic era by Ling, Hao, Lou, Xinyu, Luo, Qiuhua, He, Zhonggui, Sun, Mengchi, Sun, Jin

“…Antibiotic resistance is one of the biggest threats to global health, as it can make the treatment of bacterial infections in humans difficult owing to their…”
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Stealth CD44-targeted hyaluronic acid supramolecular nanoassemblies for doxorubicin delivery: probing the effect of uncovalent pegylation degree on cellular uptake and blood long circulation by Han, Xiaopeng, Li, Zhenbao, Sun, Jin, Luo, Cong, Li, Lin, Liu, Yuhai, Du, Yuqian, Qiu, Shuhong, Ai, Xiaoyu, Wu, Chunnuan, Lian, He, He, Zhonggui

“…Stealth active targeting nanoparticles (NPs) usually include two types of ligand sites: ligand anchored on distal ends of the polyethylene glycol (PEG) and…”
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Biomimetic nanovaccine-mediated multivalent IL-15 self-transpresentation (MIST) for potent and safe cancer immunotherapy by Wang, Kaiyuan, Zhang, Xuanbo, Ye, Hao, Wang, Xia, Fan, Zhijin, Lu, Qi, Li, Songhao, Zhao, Jian, Zheng, Shunzhe, He, Zhonggui, Ni, Qianqian, Chen, Xiaoyuan, Sun, Jin

“…Cytokine therapy, involving interleukin-15 (IL-15), is a promising strategy for cancer immunotherapy. However, clinical application has been limited due to…”
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